Tackling malaria in a country like the Central African Republic is a huge uphill battle, and my experiences there have been a healthy dose of reality, fueling my own sense of urgency to do my part in reducing the preventable suffering of the incredible women I met.

Reverse innovation is an innovation that is first adopted in developing markets and flows uphill to mature markets. This concept directs forward-looking companies to look beyond industrialized nations to draw new ideas, products, and processes from emerging economies.

When you start a novel, it is always like pushing a boulder uphill. Then, after a while, to mangle the metaphor, the boulder fills with helium and becomes a balloon that carries you the rest of the way to the top. You just have to hold your nerve and trust to narrative.

Working on 'Newsroom' has given me an appreciation of the struggle that you go through on the 24-hour news cycle. The people who are legitimately attempting to deliver honest news are really facing a tough, uphill climb that's a lot harder than any other time in history.

Doing theater anywhere, especially in L.A., is a constant uphill battle, and there's also the unsexy parts of the business that you're faced with, like getting money. It's a really great thing to do. You feel like you're really an artist when you're doing that and you're in a company of artists.

It's one of those things, like in sports and other situations in life, you're going to have some adversities and some challenges that are similar to the race. You go uphill one moment and then you go downhill, but that's life too. You've got to be willing to sometimes take it slow but keep going.

I keep trying to bring a more professional approach to New Zealand cricket. It's an uphill battle. I stay in the game because I find it intriguing and interesting. I'm not interested in coaching international sides. I don't mind short-term coaching. I don't want to get involved in the politics of teams.

It's a fun uphill struggle, making health insurance as a comedian, actor, and author. But it's hard to explain to people how I make a living. In New York, most people know enough creative types that I make some sense. But when I'm talking to someone like my suburban cousins or my mom's friends, it doesn't always go smoothly.

When you're a Republican Latino, you're traveling uphill on a lonely road. Still, it's the road I prefer. It has led me to opportunity far beyond my dreams. I've worked on eight Republican presidential races, as well as for some of the world's largest corporations, all because the doors of opportunity, not the doors of welfare, were open to me.

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