There's always the risk that there are unknown unknowns.

Birth and death; we all move between these two unknowns.

The world is divided into two categories: failures and unknowns.

To choose love and jump in not knowing, with a lot of unknowns, is a brave act.

I think every year brings unknowns that you have to deal with and handle, confront and embrace.

Film is much more of a brand business, whereas on Broadway, you can do complete unknowns and have hits.

You can't make movies without known names, and unknowns can't become known, because they can't get work.

From the dawn of history, science has probed the universe of unknowns, searching for the uniting laws of nature.

Tinkering is a way of understanding difficult problems, of wrapping our heads around them and quantifying the unknowns.

My parents gave me an incredible foundation and a strong faith in who I am. They loved me in the face of so many unknowns.

A Trump presidency will plunge the United States into an era of unknowns that has little parallel in the nation's 240-year history.

When we did 'The Last Picture Show,' the whole cast was unknowns, and we all got careers from it. Well, I don't think this could be done now.

If you look at the story of 'The Get Down,' it's the story of young people, unknowns thrown together by their resources, trying to create something.

The interesting thing about Bettie Page that I discovered was to leave the mystery. She always retained a little mystery. Let there be some unknowns.

I was interested in big unknowns, and the brain is one of the biggest, so building tools that allow us to regard the brain as a big electrical circuit appealed to me.

I am looking for unknowns who are passionate and mission-based. But I don't try to tout the next great thing I want to get in front of, because I don't set that course. The entrepreneurs do that.

For a found-footage-style movie, there's a definite advantage in using unknowns, because it helps sell the illusion that it's real. A known actor would get in the way of the suspension of disbelief.

I worry a bit about the unknowns when it comes to travelers to the war zones in Syria and Iraq. Who don't I see? And I worry about the people who may be in their basements radicalizing that I can't see.

A lot of scientists on Earth think of things that they could do in zero g. Things like the way metals cure, for example, and the way fluids react in space can tell us a lot about some of the unknowns we have on Earth.

There are known knowns. These are things we know that we know. There are known unknowns. That is to say, there are things that we know we don't know. But there are also unknown unknowns. There are things we don't know we don't know.

If you break your finger, that's on you, right? But if you get a chronic illness, if you get a serious illness or life-threatening illness, that's something I think we should all share the cost in because we all face the same unknowns and the same risks.

When I got diagnosed, the more research I did about it - MS overall, as a subject, as a disease - there's a lot of misconceptions and there's a lot of unknowns about it, and there wasn't anyone out that was close to my age or close to anything like me out there.

With 'Puddle Cruiser,' the first 15 minutes are the weakest. When you're total unknowns and you have a weak opening, it's a real problem. At some screenings, we'd see the odd walkout before the movie even got going. But to counteract that, we'd do sketches before the show to introduce the film.

We know there are certain types of viruses that are nasty - influenza, for instance, is an area that is not a blindside. But a lot of viruses have come out of nowhere, like H.I.V., or to a certain extent SARS. Because we know we have the potential to be blindsided, we really have to investigate the unknowns.

I thought, 'Oh, I'll be an independent producer. Oh, I'll be a manager.' I was going through all those things in my head, and one night, late at night, I was having what I would now describe as probably a panic attack because there were so many unknowns. An almost literal voice came into my head telling me, 'You need to write.'

I'm interested in the murky areas where there are no clear answers - or sometimes multiple answers. It's here that I try to imagine patterns or codes to make sense of the unknowns that keep us up at night. I'm also interested in the invisible space between people in communication; the space guided by translation and misinterpretation.

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