Masterful politicians and effective agents of change tend to succeed by singling out and making salient some aspect of a nation's self-understanding, sparking a sense of recognition - and ultimately moving voters in their favor. Obama made it into an art form.

It's the messiness of life that ultimately leads you to the most interesting things. Everyone asks what you would do over, and I don't know because then you have this story to tell, and if you did everything over and made it perfect, what would you talk about?

Evolution is ultimately why cancer is so deadly. Take two biopsies from different sides of a tumor, and they can be genetically very different, making it that much harder to fight. Variation is the toolbox of evolution, and this variation gives cancer strength.

Children themselves know they are being cheated. Ultimately we owe it to our children. They are in school for 190 days a year. Every moment they spend learning is precious. If a year goes by and they are not being stretched and excited, that blights their life.

If there's any message to my work, it is ultimately that it's OK to be different, that it's good to be different, that we should question ourselves before we pass judgment on someone who looks different, behaves different, talks different, is a different color.

Monetary policy ultimately must be conducted in a pragmatic manner that relies not on any particular indicator or model but, instead, reflects an ongoing assessment of a wide range of information in the context of our ever-evolving understanding of the economy.

As a real estate investor, you're ultimately accountable to you and your checkbook. Of course, you will need to stay on top of your local coding regulations and ordinances. But once you get the hang of it, you really shouldn't have any problems with ordinances.

I wouldn't sacrifice my business for no acting career because my business is something, ultimately, that I know I'm going to pass down to my kids, and that's most important to me than anything else in the world. I can't pass an acting career down to my children.

I really do love psychology and philosophy but I'm no professional at these things. Because I love seeing the true side of humanity, as I've continued that, I have ultimately lent towards philosophy and psychology but it is not something in which I try to study.

If you want to be an entertainer and just keep your audience happy, that's one thing. But to be an artist, I think, means ultimately primarily pleasing yourself, and in that respect, you constantly have this sense of confronting the expectations of your audience.

You basically have a group of four spies who are chosen for a mission they feel for the fact of how competent they are and how their expertise and they're the right one for the job. But ultimately they find out they've been actually chosen for their incompetence.

Nelson Mandela sat in a South African prison for 27 years. He was nonviolent. He negotiated his way out of jail. His honor and suffering of 27 years in a South African prison is really ultimately what brought about the freedom of South Africa. That is nonviolence.

Obviously 'Pete's Dragon' is more commercial than 'A Ghost Story,' but when making them, I'm just trying to tell a story that matters to me, that ultimately would satisfy me as a moviegoer. Because watching movies is my favorite thing to do. I watch a lot of them.

It is my Middle Eastern hat and my attachment to Israel that ultimately inspires my support for Obama. I know he understands that neither Israel nor America can afford four more years of Iran and the radical Islamists gaining strategic leverage in the Middle East.

Ultimately, it's not my job to judge the 'Housewives' - we don't editorialize on the show; we really leave it to the audience. We have a certain wink, which is the Bravo wink. We may linger on a shot or we may let something play out longer, but we leave it to you.

I'd definitely like to study other things and keep on learning all the time, but I wouldn't want to do anything else. Ultimately, acting is my craft. I've always been interested in psychology and nutrition, but I don't know that I'd go and make that my profession.

We owe it to consumers to treat their dollars with respect and to double- and triple-check our assumptions about complex marketplaces rather than getting locked into a regulatory tunnel vision that will ultimately leave consumers with fewer, more expensive choices.

I do have at home the most ridiculous number of awards for what I have done, which is nice in terms of being patted on the back, yet it does cure you of caring about what other people say about you. Ultimately, you must have your own standard of what is good enough.

I've actually always wanted to write like a one-person show that was sort of a romantic comedy - a show that was kind of cynical about romance and marriage but ultimately embraced it. Because I feel like comedy is always cynical, inherently, because it's contrarian.

Biology is far from understanding exactly how a single cell develops into a baby, but research suggests that human development can ultimately be explained in terms of biochemistry and molecular biology. Most scientists would make a similar statement about evolution.

I think that ultimately - as I say to most of the people who are acquiring art - I can tell you my reality of a piece, but ultimately what's more important will be yours. I can tell you what a piece means to me, but just as valid if not more is what it means to you.

My books always focus on the response of the characters to extreme events. As dark as they get, they are ultimately positive, uplifting books about children who take control of their lives and overcome great adversaries. I think that is why they have been so popular.

When you get something like MTV, it's like regular television. You get it, and at first it's novel and brand new and then you watch every channel, every show. And then you become a little more selective and more selective, until ultimately... you wind up with a radio.

Ultimately, the reason privacy is so vital is it's the realm in which we can do all the things that are valuable as human beings. It's the place that uniquely enables us to explore limits, to test boundaries, to engage in novel and creative ways of thinking and being.

Nothing makes you feel better than when you get into a hotel bed, and the sheets feel so good. Why shouldn't you wake up like that every day? Spend money on your mattress and bedding because these things make a difference on your sleep and, ultimately, your happiness.

People can hate on you for doing what it is that makes you happy, but ultimately, it has to belong to you. It shouldn't matter what anyone else thinks. Life is not easy. The road to happiness is not a path well trotted. You have to find your own path to enlightenment.

In truth, Wall Street is in for a radical makeover. Fewer people, lower margins, lower risk, lower compensation - and ultimately, fewer talented people. It is likely to change the culture of an industry that for nearly a century has been the money center of the world.

Our marriage is grounded in the word of God. That's really it. God is the core of our marriage, and the foundation and the blueprint for it is how we live, and being open and honest and communicating, but ultimately doing what pleases God, and not in a selfish manner.

I've always had a Marxist understanding of history: democracy is a result of a broad modernization process that happens in every country. Neocons think the use of political power can force the pace of change, but ultimately it depends on societies doing it themselves.

I've teamed up with PetSmart Charities to celebrate the five million homeless pets who've found homes through their in-store adoption centers, and to spread the word about how we can work together to save millions more pets' lives and, ultimately, end pet homelessness.

I have to say that whatever decisions I make, I really do think that movie making is a director's medium. They are the people that ultimately shape the film, and a director can take great material and turn it into garbage if they are not capable of making a good movie.

The compulsion to do good is an innate American trait. Only North Americans seem to believe that they always should, may, and actually can choose somebody with whom to share their blessings. Ultimately this attitude leads to bombing people into the acceptance of gifts.

I like knowing that the further back one traces any lineage, the narrower the path grows, to the haunt of just a few shaggy ancestors, with luck on their side, little gizmos in their cells and a future storied with impulses and choices that will ultimately define them.

Any decision that's made about my career is ultimately my decision, and it's helped me not to plan too much. I've never been the guy thinking, 'I want to do a play this year, I want to do this kind of movie or this kind of character.' I don't have that sort of control.

Advertising as the printed form of selling would seem... ultimately to be justified in so far as it serves as a means of increasing legitimate human wants, as an agency of fair and economic competition in the distribution of goods, and as a stimulant to social progress.

Trying to move the volume of products we're talking about from place to place to get it ultimately into the customer's hands, to price these items, to market these items, I think the retail business is incredibly complex. But if you get it right, it's a beautiful thing.

People are constantly asking Portia and me if we are going to have children. We thought about it. We love to be around children after they've been fed and bathed. But we ultimately decided that we don't want children of our own. There is far too much glass in our house.

What I respect as far as in myself and in others is the spirit of just doing it. For better or worse, it may work and it may not, but I'm going to go for it. Ultimately I probably prefer to be respected for that than whether it works out or not, either winning or losing.

In my brief sojourn in college, my favorite classes were political science because I loved the idea of systems we can set up that benefit society - rules we can put in place that sometimes you run against, sometimes they're painful, but ultimately they benefit the world.

Long-term unemployment is particularly costly to those directly affected, of course. But in addition, because of its negative effects on workers' skills and attachment to the labor force, long-term unemployment may ultimately reduce the productive capacity of our economy.

Our enemy is motivated by hatred and will not stop planning more plots against until they are ultimately defeated. Today was an important and necessary victory in the war, but there is a long road ahead. We must remain committed if we are to succeed and protect our liberty.

So the result was that as one approached a political convention for most of the 19th century and for most of the 20th century until the 1960's, part of the drama was the fact that you didn't know ultimately who was going to be the nominee at the end of that convention week.

If you're naturally a certain size, I think it suits you and you can see that. There's no point in trying to conform for the sake of it. People are meant to be different shapes, and their different shapes are so interesting and, ultimately, why people fall in love with them.

I'm from the Midwest, and I loved my family. I had a very good time as a child, but I was also - I have a theory about Jews growing up in the Midwest, that there is an ultimately sort of wonderful avoidance of a lot of things, and a great acceptance of whatever is happening.

The attention span of children may be one of the main reasons why an immersion in on-screen reading is so engaging, and it may also be why digital reading may ultimately prove antithetical to the long-in-development, reflective nature of the expert reading brain as we know it.

Speaking out about multiple sclerosis to others who may be dealing with this disease is actually helpful to me as well as, I hope, to others. It builds community, helps bring awareness to MS, and strengthens the MS movement that will ultimately lead to the end of this disease.

I think ultimately, bringing more nature back into the city is a way to deal with urban sprawl and things like that. If the cities feel a little more natural, people like to live there more rather than moving out and dividing up another piece of land that shouldn't be touched.

Unfair discrimination exists whether we like it or not; I wouldn't have married a gum-chewing vegetarian. Ultimately, we'll help the people we discriminate against if we try to understand more about them; genetics will lead to a world where there is a sympathy for the underdog.

I changed my thinking on the whole subject of what it is to be attractive. It's fine, but I know that ultimately what I am and who I am is not cheekbones and a jawline, if you catch my drift. I ultimately know that who I am is not directly proportional to abs or straight teeth.

I won't say that I'm an agnostic, since agnosticism maintains that one cannot know... but I'm not averse to the idea of some intelligence or some organizing force that set up the initial conditions of the universe in such a way that ultimately generated stars, planets and life.

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