There is some truth to the idea that, in the fields of science, individual contributions of great significance are possible.

I'm one of those people for whom success is one thing, but significance is another. If I can have both, I'm living the dream.

To grasp the full significance of life is the actor's duty, to interpret it is his problem, and to express it his dedication.

My grandmother's apartment had significance for me, even as a child, and I was fascinated by that world that was disappearing.

Without God, life has no purpose, and without purpose, life has no meaning. Without meaning, life has no significance or hope.

Testimony is personal knowledge, based upon the witness of the Holy Ghost, that certain facts of eternal significance are true.

Those who have never suffered the iniquities of exile cannot possibly understand the significance, the gravitas, of a mattress.

While the hippocampus itself doesn't store memories, it serves to triage our experiences based upon their survival significance.

Music is neither old nor modern: it is either good or bad music, and the date at which it was written has no significance whatever.

I am not afraid that I shall exaggerate the value and significance of life, but that I shall not be up to the occasion which it is.

Phrases that have historical significance or become headlines don't just magically appear in the moment. They are mindfully planned.

'Lord of the Rings' was a childhood favorite, though the adult Rae wishes the women in those books had more significance and agency.

NUMA is basically trying to preserve our maritime heritage by finding lost shipwrecks of historical significance before they are gone.

Authentic stardom ... is a gift which, if it is to have any permanent significance, must be bestowed by a public rather than a manager.

To a lot of us, literature's eternal significance had seemed beyond arguing - like, say, the illegality of government-sponsored torture.

People talk about 'lives of significance'-as if there's an alternative. If you're not leading a life of significance, you're not living.

What a man does for pay is of little significance. What he is, as a sensitive instrument responsive to the world's beauty, is everything!

A story so cherished it has to be dressed in casualness to disguise its significance in case the listener turned out to be unsympathetic.

The significance of playing a South Asian character that's a lead role in a network primetime television show is certainly not lost on me.

Christianity makes of life a moral drama in which we play a starring role and in which the most ordinary events take on a grand significance.

Whenever you do a new interpretation of a great, previous text of any kind, you always look for some kind of immediate significance right now.

Reconstruction is the great black hole that remains to be filled. Even experts on the Civil War don't really understand its full significance.

Being a soldier's daughter, I understand that what they are doing is the real deal. But me giving statement on the issue is of no significance.

'Culture' is a finite segment of the meaningless infinity of the world process, a segment on which human beings confer meaning and significance.

All of my tales are based on the fundamental premise that common human laws and emotions have no validity or significance in the cosmos-at-large.

I know the value and significance of trading opportunities and have seen myself from Americas to the Far East the power of trade and open markets.

Progress is measured by richness and intensity of experience - by a wider and deeper apprehension of the significance and scope of human existence.

I was a little lacking in vision as mayor - I failed to understand the significance that housing and the revitalization of housing means for a city.

If we believe that the Bible is the inspired Word of God, then we shouldn't be recognizing it only as a book of historical and economic significance.

My goal is to make fine art, and fine art comes from the soul. If you have virtuosity and facility, you can take and create something of significance.

Winning and losing have their significance in a democracy. But there should be no arrogance in victory, nor should there be any despondency in defeat.

Trying to get somebody excited about learning and trying to get somebody to think in a moral context have begun to have a lot more significance to me.

To actually play a game, where you are in the World Cup, there is significance to it, the point differential matters, all these things kind of add up.

The symbolic significance of individual athletes' achievements has sometimes proved more productive than the negotiations of diplomats or politicians.

We still don't know what evolutionary significance to attach to it, but it is at the very least interesting that a telomere gene is related to obesity.

Death threatens our speech with futility because death is not just a biological event - it is a reality we fear may rob our living of any significance.

Thinking about the artists I've loved through the years, my favorites are the ones who've made music with cultural, societal and political significance.

You have to learn how to act a pop song. You have to find the balance of the pop from the pop song and the lyrical significance of the scene you are in.

An inferior sense of smell," Marcus said, as if absolutely nothing of significance had happened, "is distinct from being told that one smells unpleasant.

President Obama can talk about having no grand schemes and making no big gains, but the reality is he can't get anything of significance through Congress.

We need to change the focus from celebrating sales at the mall to celebrating the significance of President Washington's birth to the birth of our nation.

I was brought up Catholic, and even as a little girl I was affected by the idea of giving back - doing something for the needy, something of significance.

One of the challenges for lawyers can be explaining, first of all, what the legal issue is and, second, its significance. And both of those are important.

The events in our lives happen in a sequence in time, but in their significance to ourselves they find their own order the continuous thread of revelation.

Watching a child first learn to crawl on a carpet somehow has more significance to you as you get a little older. Perhaps it is that you have suffered more.

Success means using your knowledge and experience to satisfy yourself. Significance means using your knowledge and experience to change the lives of others.

I like to aim for significance over success because rarely can you be significant and also successful, but many people can be successful and not significant.

Americans need to understand the significance of having their civil liberties dismantled. It doesn't just affect terrorists and foreigners, it affects us all.

Even a purely moral act that has no hope of any immediate and visible political effect can gradually and indirectly, over time, gain in political significance.

I'm a clean liver; I'm no thief. Kids go through phases of nicking stuff. I've nicked stuff - most people have - but I haven't nicked anything of significance.

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