In the past, biology has been a backwater type of activity - a bunch of nerds in a lab. Now the sheer potential of biology to re-program our physical world is a new reality for everyone.

I always wanted to be a filmmaker and became one through sheer single-mindedness. I came to filmmaking from a background in graphic design. I went to film school at Newcastle Polytechnic.

Despite the persistent image of the architect as a heroic loner erecting monumental edifices through sheer force of will, the building art has always been a highly cooperative enterprise.

By their innocence and goodness, by their boundless capacity for forgiveness, and by the sheer power of their faith and hope, children redeem their parents, bringing out their best selves.

My dad would go to work every day and write in a room full of funny people. He enjoyed it. I know great writers who find the process agonising but to me, writing has always been sheer joy.

What makes it all worthwhile is we just play for the sheer enjoyment of entertaining people and... make our families and the team we played on and the people watching, proud of what we did.

People think I just walk up to a sheer cliff and climb it with no knowledge of anything, when in reality, there's tons and tons of information out there, and I'm already well tapped into it.

It's hard to imagine you've got these massive wings in your back. You have to think about how it's going to affect your posture, affect the way you move, just, like, the sheer weight of them.

Among immigrants today, it is increasingly fashionable to reject American exceptionalism in favor of multiculturalism. To pretend that this isn't happening isn't optimism; it's sheer fantasy.

There are risks in the sheer brevity of Twitter, and it's actually quite an elegant art reducing what you have to say to 140 characters, and it's something that I quite enjoy attempting to do.

If a man dreams that he has committed a sin before which the sun hid his face, it is often safe to conjecture that, in sheer forgetfulness, he wore a red tie, or brown boots with evening dress.

Olay BB Cream is a lifesaver, and I wear it every day while I train and compete. Twenty-four-hour hydration and sheer color helps me look flawless even when faced with that unforgiving Jumbotron!

Nothing - and, I repeat, nothing - can affect what you build with sheer hard work. You either wait for people to define your worth or you define it with your own actions. I believe in the latter.

I like a bit of chocolate as much as the next person, but cheese is a complete world on its own. The sheer variety is staggering and there's always going to be a cheese to tickle your taste buds.

Sometimes the intensity and the grind of doing television can wear you down, but at the same time there's something about the repetition, the sheer mass of work that you do that's also liberating.

My style is cinematic; it is a touch of French woman of the '60s and American hippie with a Brooklyn edge. I love wearing wide-brim hats, newsboy caps, mini dresses and sheer blouses with details.

If people ask me for the ingredients of success, I say one is talent, two is stubbornness or determination, and third is sheer luck. You have to have two out of the three. Any two will probably do.

Nothing can really prepare you for you the sheer overwhelming experience of what it means to become a mother. It is full of complex emotions of joy, exhaustion, love, and worry, all mixed together.

I was raised well. My parents are from Nigeria; their culture is respectful. Very respectful. But I learnt that you have to be determined. It's not violence or aggression. It's sheer determination.

Unless progress with agricultural yields remains very strong, the next century will experience sheer human misery that, on a numerical scale, will exceed the worst of everything that has come before.

Balzac's ambition was to be omnipotent. He would be Michelangelesque, and that by sheer force of minuteness. He exaggerated scientifically, and made things gigantic by a microscopic fulness of detail.

It becomes difficult for a woman to become part of a lobby without eyebrows being raised. Even if she has proved herself with sheer stint of hard work, it will still be difficult for her to be accepted.

The sheer magnitude of Speaker Pelosi's spending spree is mind boggling. Most of us do not use the number 1,000,000,000,000 in our daily lives, so it is difficult to attach tangible value to the figure.

If you're in Hollywood, with no track record, it's pretty odds-on that you can get swamped and overwhelmed by the sheer scale of it all; particularly with the intense commercial push that you feel there.

The hardest part of writing 'William Shakespeare's Star Wars' was probably the sheer amount of iambic pentameter and tiptoeing around certain scenes I knew would be hot-button issues for 'Star Wars' fans.

When you're a kid, Beethoven is Beethoven, but as I've grown older, my astonishment at the sheer inventiveness of the man has increased, and I have an appreciation that I didn't have when I was in my 20s.

Oh, I love the kids more than any other age group. I hate to say that, but new life is with new kids, you know? They're the future. The sheer fact that they're young and eager, that's what makes them rule.

That was the big lesson for all of us. Everything was going great on paper, but we all became miserable because we were so caught up in the machinery of how you make that happen, it took away the sheer joy.

I've seen a lot of different training schools and dojos, and the sheer level of professionalism at the Performance Center and the state-of-the-art facility just knocked me for a six. It really blew me away.

The biggest danger to the movement is that it is getting too big in sheer weight of numbers. Other sports will become more popular in terms of numbers, and everyone will want to be involved in the Olympics.

It was sheer coincidence that 'Amaidhi Padai' had an open-ended climax. The idea for a sequel kept coming up, and I decided to act on it, nearly 20 years after the first film. It was not a planned decision.

The sheer number of legendary narratives and historically verifiable incidents invites us to revise assumptions about the origins of biological and chemical warfare and its moral and technological constraints.

I'd love to go and visit the Mosque in Mecca again, just for the sheer beauty of it, not for God - much the way a non-Catholic might go to Vatican City because of the beauty of the buildings and the artifacts.

I went into a church and simply said, 'Goodbye.' It is the terrible unfairness of life. How could God allow cancer, poverty, the sheer unfairness of so many lives? That is the question which finishes it for me.

Most visitors to Amsterdam will wander into the red-light district out of sheer curiosity. The narrow streets are mostly safe day and night - just don't try to take pictures of the women working in the windows.

In sheer genius Pascal ranks among the very greatest writers who have lived upon this earth. And his genius was not simply artistic; it displayed itself no less in his character and in the quality of his thought.

I used to think that if I had a choice between writing well and living well, I would choose the former. But now I think that's sheer lunacy. Writing weighs so much less, in the great cosmic equation, than living.

The sheer density of advertising creates a psychic mass, an overlay that can sometimes be very tense or aggressive. As a citizen, you have to participate in that every day. You have to walk by until it's changed.

Compared to some Asian countries, I think Koreans like to keep a clean, fresh, and lively look: A well-moisturized face, a light, sheer base, natural, colorless eye makeup, and a slight stain of color on the lips.

Even good shows can fail to find an audience because they're drowned out by the noise and the sheer volume of everything that is being made. It's one of the downsides of there being, as I've argued, too many shows.

If the story is good enough, if it's imaginative enough, if it's moving enough it is going to reach deeper than the level of sheer information and change somebody's life two degrees. That is an enormous achievement.

I wouldn't use the word 'scared' for my role as Hitchcock, but it was my most insecure. Taking on such a formidable, giant personality such as Hitchcock; he was one of the great geniuses of world cinema. Sheer genius.

To get an Army that's already fighting a war to change in stride to a total different military strategy on the ground - and to get everybody on the same page - was accomplished by the sheer force of Dave Petraeus' will.

You never stop thinking about technique, but really, the reason we're actors is because of the sheer joy of those few moments you get every now and again where you're totally present. The rest is just struggle and misery.

I've never had a ground-breaking hit that changed the deal. It's always been slowly but surely for me, and I've never had a moment of sheer panic when I thought I was never going to work again. So I can't really complain.

The vision, determination, stamina, hope, relentlessness, and sheer work that are involved in staying afloat, much less succeeding, are the same whether you are running a window on 47th Street or Miramax Films or Microsoft.

If you ask people what attracted them to the person they love, they never tell you of some perfect feature that focused them on sheer surfaces but rather an imperfection that allowed them to see into their uncharted depths.

I can't speak for them, of course, but I believe that most economists would accept the view that, while you sometimes can make a score by sheer luck, you can't do it constantly, unless you're willing to put the resources in.

It's Messiaen's Turangalila Symphony I'm really looking forward to. Simon Rattle does it perfectly: he understands its primal rhythmic life force, and he and the wonderful Berliners make it a sheer riot of orchestral colour.

My golf is so delicate, so tenuously wired together with silent inward prayers, exhortations and unstable visualizations, that the sheer pressure of an additional pair of eyes crumbles the whole rickety structure into rubble.

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