[To] explain the phenomena of the mineral kingdom ... systems are usually reduced to two classes, according as they refer to the origin of terrestrial bodies to FIRE or to WATER; and ... their followers have of late been distinguished by the fanciful names of Vulcanists and Neptunists. To the former of these Dr HUTTON belongs much more than to the latter; though, as he employs the agency both of fire and water in his system, he cannot, in strict propriety, be arranged with either.

It is easy to make out three areas where scientists will be concentrating their efforts in the coming decades. One is in physics, where leading theorists are striving, with the help of experimentalists, to devise a single mathematical theory that embraces all the basic phenomena of matter and energy. The other two are in biology. Biologists-and the rest of us too-would like to know how the brain works and how a single cell, the fertilized egg cell, develops into an entire organism

I believe that even a smattering of such findings in modern science and mathematics is far more compelling and exciting than most of the doctrines of pseudoscience, whose practitioners were condemned as early as the fifth century B.C. by the Ionian philosopher Heraclitus as “nigh -walkers, magicians, priests of Bacchus, priestesses of the wine-vat, mystery-mongers.” But science is more intricate and subtle, reveals a much richer imiverse, and powerfully evokes our sense of wonder.

One of the principal obstacles to the rapid diffusion of a new idea lies in the difficulty of finding suitable expression to convey its essential point to other minds. Words may have to be strained into a new sense, and scientific controversies constantly resolve themselves into differences about the meaning of words. On the other hand, a happy nomenclature has sometimes been more powerful than rigorous logic in allowing a new train of thought to be quickly and generally accepted.

The process that I want to call scientific is a process that involves the continual apprehension of meaning, the constant appraisal of significance accompanied by a running act of checking to be sure that I am doing what I want to do, and of judging correctness or incorrectness. This checking and judging and accepting, that together constitute understanding, are done by me and can be done for me by no one else. They are as private as my toothache, and without them science is dead.

The point of mathematics is that in it we have always got rid of the particular instance, and even of any particular sorts of entities. So that for example, no mathematical truths apply merely to fish, or merely to stones, or merely to colours. So long as you are dealing with pure mathematics, you are in the realm of complete and absolute abstraction. . . . Mathematics is thought moving in the sphere of complete abstraction from any particular instance of what it is talking about.

What is necessary for 'the very existence of science,' and what the characteristics of nature are, are not to be determined by pompous preconditions, they are determined always by the material with which we work, by nature herself. We look, and we see what we find, and we cannot say ahead of time successfully what it is going to look like. ... It is necessary for the very existence of science that minds exist which do not allow that nature must satisfy some preconceived conditions.

It is not enough to say that we cannot know or judge because all the information is not in. The process of gathering knowledge does not lead to knowing. A child's world spreads only a little beyond his understanding while that of a great scientist thrusts outward immeasurably. An answer is invariably the parent of a great family of new questions. So we draw worlds and fit them like tracings against the world about us, and crumple them when we find they do not fit and draw new ones.

There are some men who are counted great because they represent the actuality of their own age, and mirror it as it is. Such an one was Voltaire, of whom it was epigrammatically said: "he expressed everybody's thoughts better than anyone." But there are other men who attain greatness because they embody the potentiality of their own day and magically reflect the future. They express the thoughts which will be everybody's two or three centuries after them. Such as one was Descartes.

The physicist is like someone who's watching people playing chess and, after watching a few games, he may have worked out what the moves in the game are. But understanding the rules is just a trivial preliminary on the long route from being a novice to being a grand master. So even if we understand all the laws of physics, then exploring their consequences in the everyday world where complex structures can exist is a far more daunting task, and that's an inexhaustible one I'm sure.

After a duration of a thousand years, the power of astrology broke down when, with Copernicus, Kepler, and Galileo, the progress of astronomy overthrew the false hypothesis upon which its entire structure rested, namely, the geocentric system of the universe. ... the earth revolves in space intervened to upset the complicated play of planetary influences, and the silent stars, relegated to the unfathomable depths of the sky, no longer made their prophetic voices audible to mankind.

The world of science lives fairly comfortably with paradox. We know that light is a wave, and also that light is a particle. The discoveries made in the infinitely small world of particle physics indicate randomness and chance, and I do not find it any more difficult to live with the paradox of a universe of randomness and chance and a universe of pattern and purpose than I do with light as a wave and light as a particle. Living with contradiction is nothing new to the human being.

It has become, in my view, a bit too trendy to regard the acceptance of death as something tantamount to intrinsic dignity. Of course I agree with the preacher of Ecclesiastes that there is a time to love and a time to die - and when my skein runs out I hope to face the end calmly and in my own way. For most situations, however, I prefer the more martial view that death is the ultimate enemy - and I find nothing reproachable in those who rage mightily against the dying of the light.

If we had nothing but pecuniary rewards and worldly honours to look to, our profession would not be one to be desired. But in its practice you will find it to be attended with peculiar privileges, second to none in intense interest and pure pleasures. It is our proud office to tend the fleshly tabernacle of the immortal spirit, and our path, rightly followed, will be guided by unfettered truth and love unfeigned. In the pursuit of this noble and holy calling I wish you all God-speed.

If one in twenty does not seem high enough odds, we may, if we prefer it, draw the line at one in fifty (the 2 per cent. point), or one in a hundred (the 1 per cent. point). Personally, the writer prefers to set a low standard of significance at the 5 per cent. point, and ignore entirely all results which fail to reach this level. A scientific fact should be regarded as experimentally established only if a properly designed experiment rarely fails to give this level of significance.

For strictly scientific or technological purposes all this is irrelevant. On a pragmatic view, as on a religious view, theory and concepts are held in faith. On the pragmatic view the only thing that matters is that the theory is efficacious, that it 'works' and that the necessary preliminaries and side issues do not cost too much in time and effort. Beyond that, theory and concepts go to constitute a language in which the scientistic matters at issue can be formulated and discussed.

A bird maintains itself in the air by imperceptible balancing, when near to the mountains or lofty ocean crags; it does this by means of the curves of the winds which as they strike against these projections, being forced to preserve their first impetus bend their straight course towards the sky with divers revolutions, at the beginning of which the birds come to a stop with their wings open, receiving underneath themselves the continual buffetings of the reflex courses of the winds.

We are apt to consider that invention is the result of spontaneous action of some heavenborn genius, whose advent we must patiently wait for, but cannot artificially produce. It is unquestionable, however, that education, legal enactments, and general social conditions have a stupendous influence on the development of the originative faculty present in a nation and determine whether it shall be a fountain of new ideas or become simply a purchaser from others of ready-made inventions.

The life and soul of science is its practical application, and just as the great advances in mathematics have been made through the desire of discovering the solution of problems which were of a highly practical kind in mathematical science, so in physical science many of the greatest advances that have been made from the beginning of the world to the present time have been made in the earnest desire to turn the knowledge of the properties of matter to some purpose useful to mankind.

The mechanist is intimately convinced that a precise knowledge of the chemical constitution, structure, and properties of the various organelles of a cell will solve biological problems. This will come in a few centuries. For the time being, the biologist has to face such concepts as orienting forces or morphogenetic fields. Owing to the scarcity of chemical data and to the complexity of life, and despite the progresses of biochemistry, the biologist is still threatened with vertigo.

In order to survive, an animal must be born into a favoring or at least tolerant environment. Similarly, in order to achieve preservation and recognition, a specimen of fossil man must be discovered in intelligence, attested by scientific knowledge, and interpreted by evolutionary experience. These rigorous prerequisites have undoubtedly caused many still-births in human palaeontology and are partly responsible for the high infant mortality of discoveries of geologically ancient man.

We can distinguish three groups of scientific men. In the first and very small group we have the men who discover fundamental relations. Among these are van't Hoff, Arrhenius and Nernst. In the second group we have the men who do not make the great discovery but who see the importance and bearing of it, and who preach the gospel to the heathen. Ostwald stands absolutely at the head of this group. The last group contains the rest of us, the men who have to have things explained to us.

When a physician is called to a patient, he should decide on the diagnosis, then the prognosis, and then the treatment. ... Physicians must know the evolution of the disease, its duration and gravity in order to predict its course and outcome. Here statistics intervene to guide physicians, by teaching them the proportion of mortal cases, and if observation has also shown that the successful and unsuccessful cases can be recognized by certain signs, then the prognosis is more certain.

On our planet, all objects are subject to continual and inevitable changes which arise from the essential order of things. These changes take place at a variable rate according to the nature, condition, or situation of the objects involved, but are nevertheless accomplished within a certain period of time. Time is insignificant and never a difficulty for Nature. It is always at her disposal and represents an unlimited power with which she accomplishes her greatest and smallest tasks.

How is it that hardly any major religion has looked at science and concluded, “This is better than we thought! The Universe is much bigger than our prophets said, grander, more subtle, more elegant?” Instead they say, “No, no, no! My god is a little god, and I want him to stay that way.” A religion, old or new, that stressed the magnificence of the Universe as revealed by modern science might be able to draw forth reserves of reverence and awe hardly tapped by the conventional faiths.

Correct is to recognize what diseases are and whence they come; which are long and which are short; which are mortal and which are not; which are in the process of changing into others; which are increasing and which are diminishing; which are major and which are minor; to treat the diseases that can be treated, but to recognize the ones that cannot be, and to know why they cannot be; by treating patients with the former, to give them the benefit of treatment as far as it is possible.

Every lecture should state one main point and repeat it over and over, like a theme with variations. An audience is like a herd of cows, moving slowly in the direction they are being driven towards. If we make one point, we have a good chance that the audience will take the right direction; if we make several points, then the cows will scatter all over the field. The audience will lose interest and everyone will go back to the thoughts they interrupted in order to come to our lecture.

The Mathematics are Friends to Religion, inasmuch as they charm the Passions, restrain the Impetuosity of the Imagination, and purge the Mind from Error and Prejudice. Vice is Error, Confusion, and false Reasoning; and all Truth is more or less opposite to it. Besides, Mathematical Studies may serve for a pleasant Entertainment for those Hours which young Men are apt to throw away upon their Vices; the Delightfulness of them being such as to make Solitude not only easy, but desirable.

It required unusual inquisitiveness to pursue the development of scientific curiosities such as charged pith balls, the voltaic cell, and the electrostatic machine. Without such endeavors and the evolution of associated instrumentation, initially of purely scientific interest, most of the investigations that lead to the basic equations of electromagnetism would have been missed. ... We would have been deprived of electromagnetic machinery as well as knowledge of electromagnetic waves.

The history of acceptance of new theories frequently shows the following steps: At first the new idea is treated as pure nonsense, not worth looking at. Then comes a time when a multitude of contradictory objections are raised, such as: the new theory is too fancy, or merely a new terminology; it is not fruitful, or simply wrong. Finally a state is reached when everyone seems to claim that he had always followed this theory. This usually marks the last state before general acceptance.

I have tried to show why I believe that the biologist is the most romantic figure on earth at the present day. At first sight he seems to be just a poor little scrubby underpaid man, groping blindly amid the mazes of the ultra-microscopic, engaging in bitter and lifelong quarrels over the nephridia of flatworms, waking perhaps one morning to find that someone whose name he has never heard has demolished by a few crucial experiments the work which he had hoped would render him immortal.

There is a great deal of emotional satisfaction in the elegant demonstration, in the elegant ordering of facts into theories, and in the still more satisfactory, still more emotionally exciting discovery that the theory is not quite right and has to be worked over again, very much as any other work of art-a painting, a sculpture has to be worked over in the interests of aesthetic perfection. So there is no scientist who is not to some extent worthy of being described as artist or poet.

Alcoholism, the opium habit and tobaccoism are a trio of poison habits which have been weighty handicaps to human progress during the last three centuries. In the United States, the subtle spell of opium has been broken by restrictive legislation; the grip of the rum demon has been loosened by the Prohibition Amendment to the Constitution, but the tobacco habit still maintains its strangle-hold and more than one hundred million victims of tobaccoism daily burn incense to the smoke god.

One can truly say that the irresistible progress of natural science since the time of Galileo has made its first halt before the study of the higher parts of the brain, the organ of the most complicated relations of the animal to the external world. And it seems, and not without reason, that now is the really critical moment for natural science; for the brain, in its highest complexity-the human brain-which created and creates natural science, itself becomes the object of this science.

...those who sit at their work and are therefore called 'chair workers,' such as cobblers and tailors, suffer from their own particular diseases ... [T]hese workers ... suffer from general ill-health and an excessive accumulation of unwholesome humors caused by their sedentary life ... so to some extent counteract the harm done by many days of sedentary life. On the association between chronic inactivity and poor health. Ramazzini urged that workers should at least exercise on holidays

All the species recognized by Botanists came forth from the Almighty Creator's hand, and the number of these is now and always will be exactly the same, while every day new and different florists' species arise from the true species so-called by Botanists, and when they have arisen they finally revert to the original forms. Accordingly to the former have been assigned by Nature fixed limits, beyond which they cannot go: while the latter display without end the infinite sport of Nature.

While the law [of competition] may be sometimes hard for the individual, it is best for the race, because it insures the survival of the fittest in every department. We accept and welcome, therefore, as conditions to which we must accommodate ourselves, great inequality of environment, the concentration of business, industrial and commercial, in the hands of a few, and the law of competition between these, as being not only beneficial, but essential for the future progress of the race.

Because we do not understand the brain very well we are constantly tempted to use the latest technology as a model for trying to understand it. In my childhood we were always assured that the brain was a telephone switchboard...Sherrington, the great British neuroscientist, thought the brain worked like a telegraph system. Freud often compared the brain to hydraulic and electromagnetic systems. Leibniz compared it to a mill...At present, obviously, the metaphor is the digital computer.

What politicians do not understand is that [Ian] Wilmut discovered not so much a technical trick as a new law of nature. We now know that an adult mammalian cell can fire up all the dormant genetic instructions that shut down as it divides and specializes and ages, and thus can become a source of new life. You can outlaw technique; you cannot repeal biology. Writing after Wilmut's successful cloning of the sheep, Dolly, that research on the cloning of human beings cannot be suppressed.

[Vestiges begins] from principles which are at variance with all sober inductive truth. The sober facts of geology shuffled, so as to play a rogue's game; phrenology (that sinkhole of human folly and prating coxcombry); spontaneous generation; transmutation of species; and I know not what; all to be swallowed, without tasting and trying, like so much horse-physic!! Gross credulity and rank infidelity joined in unlawful marriage, and breeding a deformed progeny of unnatural conclusions!

[About reading Rachel Carson's Silent Spring, age 14, in the back seat of his parents' sedan. I almost threw up. I got physically ill when I learned that ospreys and peregrine falcons weren't raising chicks because of what people were spraying on bugs at their farms and lawns. This was the first time I learned that humans could impact the environment with chemicals. [That a corporation would create a product that didn't operate as advertised] was shocking in a way we weren't inured to.

[Mathematics] is security. Certainty. Truth. Beauty. Insight. Structure. Architecture. I see mathematics, the part of human knowledge that I call mathematics, as one thing - one great, glorious thing. Whether it is differential topology, or functional analysis, or homological algebra, it is all one thing. ... They are intimately interconnected, they are all facets of the same thing. That interconnection, that architecture, is secure truth and is beauty. That's what mathematics is to me.

If we can combine our knowledge of science with the wisdom of wildness, if we can nurture civilization through roots in the primitive, man's potentialities appear to be unbounded, Through this evolving awareness, and his awareness of that awareness, he can emerge with the miraculous-to which we can attach what better name than 'God'? And in this merging, as long sensed by intuition but still only vaguely perceived by rationality, experience may travel without need for accompanying life.

The ends of scientific classification are best answered, when the objects are formed into groups respecting which a greater number of general propositions can be made, and those propositions more important, than could be made respecting any other groups into which the same things could be distributed. ... A classification thus formed is properly scientific or philosophical, and is commonly called a Natural, in contradistinction to a Technical or Artificial, classification or arrangement.

However, the small probability of a similar encounter [of the earth with a comet], can become very great in adding up over a huge sequence of centuries. It is easy to picture to oneself the effects of this impact upon the Earth. The axis and the motion of rotation changed; the seas abandoning their old position to throw themselves toward the new equator; a large part of men and animals drowned in this universal deluge, or destroyed by the violent tremor imparted to the terrestrial globe.

Relativity was a highly technical new theory that gave new meanings to familiar concepts and even to the nature of the theory itself. The general public looked upon relativity as indicative of the seemingly incomprehensible modern era, educated scientists despaired of ever understanding what Einstein had done, and political ideologues used the new theory to exploit public fears and anxieties-all of which opened a rift between science and the broader culture that continues to expand today.

In the first book I shall describe all the positions of the spheres, along with the motions which I attribute to the Earth, so that the book will contain as it were the general structure of the universe. In the remaining books I relate the motions of the remaining stars, and all the spheres, to the mobility of the Earth, so that it can be thence established how far the motions and appearances of the remaining stars and spheres can be saved, if they are referred to the motions of the Earth.

The very hope of experimental philosophy, its expectation of constructing the sciences into a true philosophy of nature, is basedon induction, or, if you please, the a priori presumption, that physical causation is universal; that the constitution of nature is written in its actual manifestations, and needs only to be deciphered by experimental and inductive research; that it is not a latent invisible writing, to be brought out by the magic of mental anticipation or metaphysical mediation.

I tell my students, with a feeling of pride that I hope they will share, that the carbon, nitrogen, and oxygen that make up ninety-nine per cent of our living substance were cooked in the deep interiors of earlier generations of dying stars. Gathered up from the ends of the universe, over billions of years, eventually they came to form, in part, the substance of our sun, its planets, and ourselves. Three billion years ago, life arose upon the earth. It is the only life in the solar system.

On May 15, 1957 Linus Pauling made an extraordinary speech to the students of Washington University. ... It was at this time that the idea of the scientists' petition against nuclear weapons tests was born. That evening we discussed it at length after dinner at my house and various ones of those present were scribbling and suggesting paragraphs. But it was Linus Pauling himself who contributed the simple prose of the petition that was much superior to any of the suggestions we were making.

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