Well do I remember that dark hot little office in the hospital at Begumpett, with the necessary gleam of light coming in from under the eaves of the veranda. I did not allow the punka to be used because it blew about my dissected mosquitoes, which were partly examined without a cover-glass; and the result was that swarms of flies and of 'eye-flies' - minute little insects which try to get into one's ears and eyelids - tormented me at their pleasure

The nucleic acids, as constituents of living organisms, are comparable In importance to proteins. There is evidence that they are Involved In the processes of cell division and growth, that they participate In the transmission of hereditary characters, and that they are important constituents of viruses. An understanding of the molecular structure of the nucleic acids should be of value In the effort to understand the fundamental phenomena of life.

Medicine is a social science, and politics is nothing else but medicine on a large scale. Medicine, as a social science, as the science of human beings, has the obligation to point out problems and to attempt their theoretical solution: the politician, the practical anthropologist, must find the means for their actual solution. The physicians are the natural attorneys of the poor, and social problems fall to a large extent within their jurisdiction.

Politicians, real-estate agents, used-car salesmen, and advertising copy-writers are expected to stretch facts in self-serving directions, but scientists who falsify their results are regarded by their peers as committing an inexcusable crime. Yet the sad fact is that the history of science swarms with cases of outright fakery and instances of scientists who unconsciously distorted their work by seeing it through lenses of passionately held beliefs.

The youthful brain should in general not be burdened with things ninety-five percent of which it cannot use and hence forgets again... In many cases, the material to be learned in the various subjects is so swollen that only a fraction of it remains in the head of the individual pupil, and only a fraction of this abundance can find application, while on the other hand it is not adequate for the man working and earning his living in a definite field.

The greatest marvel is not in the individual. It is in the succession, in the renewal and in the duration of the species that Nature would seem quite inconceivable. This power of producing its likeness that resides in animals and plants, this form of unity, always subsisting and appearing eternal, this procreative virtue which is perpetually expressed without ever being destroyed, is for us a mystery which, it seems, we will never be able to fathom.

The essential fact which emerges ... is that the three smallest and most active reservoirs ( of carbon in the global carbon cycle), the atmosphere, the plants and the soil, are all of roughly the same size. This means that large human disturbance of any one of these reservoirs will have large effects on all three. We cannot hope either to understand or to manage the carbon in the atmosphere unless we understand and manage the trees and the soil too.

Were I disposed to consider the comparative merit of each of them [facts or theories in medical practice], I should derive most of the evils of medicine from supposed facts, and ascribe all the remedies which have been uniformly and extensively useful, to such theories as are true. Facts are combined and rendered useful only by means of theories, and the more disposed men are to reason, the more minute and extensive they become in their observations

Our revels now are ended. These our actors, As I foretold you, were all spirits and Are melted into air, into thin air: And, like the baseless fabric of this vision, The cloud-capp'd towers, the gorgeous palaces, The solemn temples, the great globe itself, Yea, all which it inherit, shall dissolve And, like this insubstantial pageant faded, Leave not a rack behind. We are such stuff As dreams are made on, and our little life Is rounded with a sleep.

During the first half of the present century we had an Alexander von Humboldt, who was able to scan the scientific knowledge of his time in its details, and to bring it within one vast generalization. At the present juncture, it is obviously very doubtful whether this task could be accomplished in a similar way, even by a mind with gifts so peculiarly suited for the purpose as Humboldt's was, and if all his time and work were devoted to the purpose.

I can live with doubt and uncertainty and not knowing. I think it is much more interesting to live not knowing than to have answers that might be wrong. If we will only allow that, as we progress, we remain unsure, we will leave opportunities for alternatives. We will not become enthusiastic for the fact, the knowledge, the absolute truth of the day, but remain always uncertain … In order to make progress, one must leave the door to the unknown ajar.

Our immediate interests are after all of but small moment. It is what we do for the future, what we add to the sum of man's knowledge, that counts most. As someone has said, 'The individual withers and the world is more and more.' Man dies at 70, 80, or 90, or at some earlier age, but through his power of physical reproduction, and with the means that he has to transmit the results of effort to those who come after him, he may be said to be immortal.

Gradually, ... the aspect of science as knowledge is being thrust into the background by the aspect of science as the power of manipulating nature. It is because science gives us the power of manipulating nature that it has more social importance than art. Science as the pursuit of truth is the equal, but not the superior, of art. Science as a technique, though it may have little intrinsic value, has a practical importance to which art cannot aspire.

Since, then, there is no objection to the mobility of the Earth, I think it must now be considered whether several motions are appropriate for it, so that it can be regarded as one of the wandering stars. For the fact that it is not the centre of all revolutions is made clear by the apparent irregular motion of the wandering stars, and their variable distances from the Earth, which cannot be understood in a circle having the same centre as the Earth.

The total quantity of all the forces capable of work in the whole universe remains eternal and unchanged throughout all their changes. All change in nature amounts to this, that force can change its form and locality, without its quantity being changed. The universe possesses, once for all, a store of force which is not altered by any change of phenomena, can neither be increased nor diminished, and which maintains any change which takes place on it.

It seems that the increased number of scientific workers, their being split up into groups whose studies are limited to a small subject, and over-specialization have brought about a shrinking of intelligence. There is no doubt that the quality of any human group decreases when the number of the individuals composing this group increases beyond certain limits... The best way to increase the intelligence of scientists would be to decrease their number.

Science is a magnificent force, but it is not a teacher of morals. It can perfect machinery, but it adds no moral restraints to protect society from the misuse of the machine. It can also build gigantic intellectual ships, but it constructs no moral rudders for the control of storm tossed human vessel. It not only fails to supply the spiritual element needed but some of its unproven hypotheses rob the ship of its compass and thus endangers its cargo.

Thomas Edison reads not for entertainment but to increase his store of knowledge. He sucks in information as eagerly as the bee sucks honey from flowers. The whole world, so to speak, pours its wisdom into his mind. He regards it as a criminal waste of time to go through the slow and painful ordeal of ascertaining things for one's self if these same things have already been ascertained and made available by others. In Edison's mind knowledge is power.

As agonizing a disease as cancer is, I do not think it can be said that our civilization is threatened by it. ... But a very plausible case can be made that our civilization is fundamentally threatened by the lack of adequate fertility control. Exponential increases of population will dominate any arithmetic increases, even those brought about by heroic technological initiatives, in the availability of food and resources, as Malthus long ago realized.

We academic scientists move within a certain sphere, we can go on being useless up to a point, in the confidence that sooner or later some use will be found for our studies. The mathematician, of course, prides himself on being totally useless, but usually turns out to be the most useful of the lot. He finds the solution but he is not interested in what the problem is: sooner or later, someone will find the problem to which his solution is the answer.

His [Henry Cavendish's] Theory of the Universe seems to have been, that it consisted solely of a multitude of objects which could be weighed, numbered, and measured; and the vocation to which he considered himself called was, to weigh, number and measure as many of those objects as his allotted three-score years and ten would permit. This conviction biased all his doings, alike his great scientific enterprises, and the petty details of his daily life.

Science is wonderful at destroying metaphysical answers, but incapable of providing substitute ones. Science takes away foundations without providing a replacement. Whether we want to be there or not, science has put us in the position of having to live without foundations. It was shocking when Nietzsche said this, but today it is commonplace; our historical position-and no end to it is in sight-is that of having to philosophise without 'foundations'.

The attainment of knowledge is the high and exclusive attribute of man, among the numberless myriads of animated beings, inhabitants of the terrestrial globe. On him alone is bestowed, by the bounty of the Creator of the universe, the power and the capacity of acquiring knowledge. Knowledge is the attribute of his nature which at once enables him to improve his condition upon earth, and to prepare him for the enjoyment of a happier existence hereafter.

If I have put the case of science at all correctly, the reader will have recognised that modern science does much more than demand that it shall be left in undisturbed possession of what the theologian and metaphysician please to term its 'legitimate field'. It claims that the whole range of phenomena, mental as well as physical-the entire universe-is its field. It asserts that the scientific method is the sole gateway to the whole region of knowledge.

As mineralogy constitutes a part of chemistry, it is clear that this arrangement [of minerals] must derive its principles from chemistry. The most perfect mode of arrangement would certainly be to allow bodies to follow each other according to the order of their electro-chemical properties, from the most electro-negative, oxygen, to the most electro-positive, potassium; and to place every compound body according to its most electro-positive ingredient.

There are many points in the history of an invention which the inventor himself is apt to overlook as trifling, but in which posterity never fail to take a deep interest. The progress of the human mind is never traced with such a lively interest as through the steps by which it perfects a great invention; and there is certainly no invention respecting which this minute information will be more eagerly sought after, than in the case of the steam-engine.

Physio-philosophy has to show how, and in accordance indeed with what laws, the Material took its origin; and, therefore, how something derived its existence from nothing. It has to portray the first periods of the world's development from nothing; how the elements and heavenly bodies originated; in what method by self-evolution into higher and manifold forms, they separated into minerals, became finally organic, and in Man attained self-consciousness.

We greatly want a brief word to express the science of improving stock, which is by no means confined to questions of judicious mating, but which, especially in the case of man, takes cognizance of all influences that tend in however remote a degree to give to the more suitable races or strains of blood a better chance of prevailing speedily over the less suitable than they otherwise would have had. The word eugenics would sufficiently express the idea.

This success permits us to hope that after thirty or forty years of observation on the new Planet [Neptune], we may employ it, in its turn, for the discovery of the one following it in its order of distances from the Sun. Thus, at least, we should unhappily soon fall among bodies invisible by reason of their immense distance, but whose orbits might yet be traced in a succession of ages, with the greatest exactness, by the theory of Secular Inequalities.

It is possible to enjoy the Mozart concerto without being able to play the clarinet. In fact, you can learn to be an expert connoisseur of music without being able to play a note on any instrument. Of course, music would come to a halt if nobody ever learned to play it. But if everybody grew up thinking that music was synonymous with playing it, think how relatively impoverished many lives would be. Couldn't we learn to think of science in the same way?

The Primal Plant is going be the strangest creature in the world, which Nature herself must envy me. With this model and the key to it, it will be possible to go on for ever inventing plants and know that their existence is logical; that is to say, if they do not actually exist, they could, for they are not the shadowy phantoms of a vain imagination, but possess an inner necessity and truth. The same law will be applicable to all other living organisms.

Creating a new theory is not like destroying an old barn and erecting a skyscraper in its place. It is rather like climbing a mountain, gaining new and wider views, discovering unexpected connections between our starting points and its rich environment. But the point from which we started out still exists and can be seen, although it appears smaller and forms a tiny part of our broad view gained by the mastery of the obstacles on our adventurous way up.

Science does not rest upon solid bedrock. The bold structure of its theories rises, as it were, above a swamp. It is like a building erected on piles. The piles are driven down from above into the swamp, but not down to any natural or 'given' base; and if we stop driving the piles deeper, it is not because we have reached firm ground. We simply stop when we are satisfied that the piles are firm enough to carry the structure, at least for the time being.

My diary entries during this period constantly refer to the importance of learning how to take criticism. If you shut yourself in your own little world, that will be the death of your theory. On the other hand, many of the criticisms you receive are pointless and simply reflect the view that anything new is bad. In such a delicate situation it is crucial to tread gingerly and be careful to appreciate the difference between pertinent and idiotic comments.

At no period of [Michael Faraday's] unmatched career was he interested in utility. He was absorbed in disentangling the riddles of the universe, at first chemical riddles, in later periods, physical riddles. As far as he cared, the question of utility was never raised. Any suspicion of utility would have restricted his restless curiosity. In the end, utility resulted, but it was never a criterion to which his ceaseless experimentation could be subjected.

As historians, we refuse to allow ourselves these vain speculations which turn on possibilities that, in order to be reduced to actuality, suppose an overturning of the Universe, in which our globe, like a speck of abandoned matter, escapes our vision and is no longer an object worthy of our regard. In order to fix our vision, it is necessary to take it such as it is, to observe well all parts of it, and by indications infer from the present to the past.

Experiments in geology are far more difficult than in physics and chemistry because of the greater size of the objects, commonly outside our laboratories, up to the earth itself, and also because of the fact that the geologic time scale exceeds the human time scale by a million and more times. This difference in time allows only direct observations of the actual geologic processes, the mind having to imagine what could possibly have happened in the past.

There are photons that have been traveling for 30,000 years, and I'm... snatching them from this journey and planting them into my digital detector. And then I started feeling bad for the photon, and I said maybe it wanted to continue but I got in its way. But then I said, no, those are probably happier photons than the one that slammed into the mountainside that will go unanalyzed and will not contribute to the depth of our understanding of the universe.

The story of scientific discovery has its own epic unity-a unity of purpose and endeavour-the single torch passing from hand to hand through the centuries; and the great moments of science when, after long labour, the pioneers saw their accumulated facts falling into a significant order-sometimes in the form of a law that revolutionised the whole world of thought-have an intense human interest, and belong essentially to the creative imagination of poetry.

Computers and rocket ships are examples of invention, not of understanding. ... All that is needed to build machines is the knowledge that when one thing happens, another thing happens as a result. It's an accumulation of simple patterns. A dog can learn patterns. There is no "why&rdqo"; in those examples. We don't understand why electricity travels. We don't know why light travels at a constant speed forever. All we can do is observe and record patterns.

For books [Charles Darwin] had no respect, but merely considered them as tools to be worked with. ... he would cut a heavy book in half, to make it more convenient to hold. He used to boast that he had made Lyell publish the second edition of one of his books in two volumes, instead of in one, by telling him how ho had been obliged to cut it in half. ... his library was not ornamental, but was striking from being so evidently a working collection of books.

Professor Brown: 'Since this slide was made,' he opined, 'My students have re-examined the errant points and I am happy to report that all fall close to the [straight] line.' Questioner: 'Professor Brown, I am delighted that the points which fell off the line proved, on reinvestigation, to be in compliance. I wonder, however, if you have had your students reinvestigate all these points that previously fell on the line to find out how many no longer do so?'

Even those to whom Providence has allotted greater strength of understanding, can expect only to improve a single science. In every other part of learning, they must be content to follow opinions, which they are not able to examine; and, even in that which they claim as peculiarly their own, can seldom add more than some small particle of knowledge, to the hereditary stock devolved to them from ancient times, the collective labour of a thousand intellects.

[N]o scientist likes to be criticized. ... But you don't reply to critics: "Wait a minute, wait a minute; this is a really good idea. I'm very fond of it. It's done you no harm. Please don't attack it." That's not the way it goes. The hard but just rule is that if the ideas don't work, you must throw them away. Don't waste any neurons on what doesn't work. Devote those neurons to new ideas that better explain the data. Valid criticism is doing you a favor.

Now I must take you to a very interesting part of our subject-to the relation between the combustion of a candle and that living kind of combustion which goes on within us. In every one of us there is a living process of combustion going on very similar to that of a candle, and I must try to make that plain to you. For it is not merely true in a poetical sense-the relation of the life of man to a taper; and if you will follow, I think I can make this clear.

Many will, no doubt, prefer to retain old unsystematic names as far as possible, but it is easy to see that the desire to avoid change may carry us too far in this direction; it will undoubtedly be very inconvenient to the present generation of chemists to abandon familiar and cherished names, but nevertheless it may be a wise course to boldly face the difficulty, rather than inflict on coming generations a partially illogical and unsystematic nomenclature.

Man is not a machine, ... although man most certainly processes information, he does not necessarily process it in the way computers do. Computers and men are not species of the same genus. .... No other organism, and certainly no computer, can be made to confront genuine human problems in human terms. ... However much intelligence computers may attain, now or in the future, theirs must always be an intelligence alien to genuine human problems and concerns.

If the 'Principle of Relativity' in an extreme sense establishes itself, it seems as if even Time would become discontinuous and be supplied in atoms, as money is doled out in pence or centimes instead of continuously;-in which case our customary existence will turn out to be no more really continuous than the events on a kinematograph screen;-while that great agent of continuity, the Ether of Space, will be relegated to the museum of historical curiosities.

Just by studying mathematics we can hope to make a guess at the kind of mathematics that will come into the physics of the future... If someone can hit on the right lines along which to make this development, it may lead to a future advance in which people will first discover the equations and then, after examining them, gradually learn how to apply them... My own belief is that this is a more likely line of progress than trying to guess at physical pictures.

On the whole, at least in the author's experience, the preparation of species-specific antiserum fractions and the differentiation of closely related species with precipitin sera for serum proteins does not succeed so regularly as with agglutinins and lysins for blood cells. This may be due to the fact that in the evolutional scale the proteins undergo continuous variations whereas cell antigens are subject to sudden changes not linked by intermediary stages.

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