The wonderful structure of the animal system will probably never permit us to look upon it as a merely physical apparatus, yet the demands of science require that the evidently magnified principles of vitality should be reduced to their natural spheres, or if truth requires, wholly subverted in favor of those more cognizable by the human understanding. The spirit of the age will not tolerate in the devotee of science a quiet indifference.

The doctrine called Philosophical Necessity is simply this: that, given the motives which are present to an individual's mind, and given likewise the character and disposition of the individual, the manner in which he will act might be unerringly inferred: that if we knew the person thoroughly, and knew all the inducements which are acting upon him, we could foretell his conduct with as much certainty as we can predict any physical event.

Science is not, as so many seem to think, something apart, which has to do with telescopes, retorts, and test-tubes, and especially with nasty smells, but it is a way of searching out by observation, trial and classification; whether the phenomena investigated be the outcome of human activities, or of the more direct workings of nature's laws. Its methods admit of nothing untidy or slip-shod; its keynote is accuracy and its goal is truth.

To regulate something always requires two opposing factors. You cannot regulate by a single factor. To give an example, the traffic in the streets could not be controlled by a green light or a red light alone. It needs a green light and a red light as well. The ratio between retine and promine determines whether there is any motion, any growth, or not. Two different inclinations have to be there in readiness to make the cells proliferate.

I approached the bulk of my schoolwork as a chore rather than an intellectual adventure. The tedium was relieved by a few courses that seem to be qualitatively different. Geometry was the first exciting course I remember. Instead of memorizing facts, we were asked to think in clear, logical steps. Beginning from a few intuitive postulates, far reaching consequences could be derived, and I took immediately to the sport of proving theorems.

My present and most fixed opinion regarding the nature of alcoholic fermentation is this: The chemical act of fermentation is essentially a phenomenon correlative with a vital act, beginning and ending with the latter. I believe that there is never any alcoholic fermentation without their being simultaneously the organization, development, multiplication of the globules, or the pursued, continued life of globules which are already formed.

No physiologist who calmly considers the question in connection with the general truths of his science, can long resist the conviction that different parts of the cerebrum subserve different kinds of mental action. Localization of function is the law of all organization whatever: separateness of duty is universally accompanied with separateness of structure: and it would be marvellous were an exception to exist in the cerebral hemispheres.

There's nothing situate under heaven's eye But hath his bond in earth, in sea, in sky. The beasts, the fishes, and the winged fowls Are their males' subjects and at their controls. Man, more divine, the master of all these, Lord of the wide world and wild wat'ry seas, Indu'd with intellectual sense and souls, Of more pre-eminence than fish and fowls, Are masters to their females, and their lords; Then let your will attend on their accords.

Groups do not have experiences except insofar as all their members do. And there are no experiences... that all the members of a scientific community must share in the course of a [scientific] revolution. Revolutions should be described not in terms of group experience but in terms of the varied experiences of individual group members. Indeed, that variety itself turns out to play an essential role in the evolution of scientific knowledge.

I maintain that the human mystery is incredibly demeaned by scientific reductionism, with its claim in promissory materialism to account eventually for all of the spiritual world in terms of patterns of neuronal activity. This belief must be classed as a superstition. ... We have to recognize that we are spiritual beings with souls existing in a spiritual world as well as material beings with bodies and brains existing in a material world.

We regard as 'scientific' a method based on deep analysis of facts, theories, and views, presupposing unprejudiced, unfearing open discussion and conclusions. The complexity and diversity of all the phenomena of modern life, the great possibilities and dangers linked with the scientific-technical revolution and with a number of social tendencies demand precisely such an approach, as has been acknowledged in a number of official statements.

The scientific value of truth is not, however, ultimate or absolute. It rests partly on practical, partly on aesthetic interests. As our ideas are gradually brought into conformity with the facts by the painful process of selection,-for intuition runs equally into truth and into error, and can settle nothing if not controlled by experience,-we gain vastly in our command over our environment. This is the fundamental value of natural science

In the Middle Ages people believed that the earth was flat, for which they had at least the evidence of their senses: we believe it to be round, not because as many as 1 percent of us could give physical reasons for so quaint a belief, but because modern science has convinced us that nothing that is obvious is true, and that everything that is magical, improbable, extraordinary, gigantic, microscopic, heartless, or outrageous is scientific.

This single Stick, which you now behold ingloriously lying in that neglected Corner, I once knew in a flourishing State in a Forest: It was full of Sap, full of Leaves, and full of Boughs: But now, in vain does the busy Art of Man pretend to vie with Nature, by tying that withered Bundle of Twigs to its sapless Trunk: It is at best but the Reverse of what it was; a Tree turned upside down, the Branches on the Earth, and the Root in the Air.

If the germ plasm wants to swim in the ocean, it makes itself a fish; if the germ plasm wants to fly in the air, it makes itself a bird. If it wants to go to Harvard, it makes itself a man. The strangest thing of all is that the germ plasm that we carry around within us has done all those things. There was a time, hundreds of millions of years ago, when it was making fish. Then ... amphibia ... reptiles ... mammals, and now it's making men.

Louis [Leakey] was anxious to initiate a scientific study of these chimpanzees. It would be difficult, he emphasized, for nothing was known; there were no guidelines for such a field study; and the habitat was remote and rugged. Dangerous wild animals would be living there, and chimpanzees themselves were considered at least four times stronger than humans. I remember wondering what kind of scientist he would find for such a herculean task.

Science and religion...are friends, not foes, in the common quest for knowledge. Some people may find this surprising, for there's a feeling throughout our society that religious belief is outmoded, or downright impossible, in a scientific age. I don't agree. In fact, I'd go so far as to say that if people in this so-called 'scientific age' knew a bit more about science than many of them actually do, they'd find it easier to share my views.

In science it often happens that scientists say, 'You know that's a really good argument; my position is mistaken,' and then they would actually change their minds and you never hear that old view from them again. They really do it. It doesn't happen as often as it should, because scientists are human and change is sometimes painful. But it happens every day. I cannot recall the last time something like that happened in politics or religion.

Nor has science sufficient humanity, so long as the naturalist overlooks the wonderful congruity which subsists between man and the world; of which he is lord, not because he is the most subtile inhabitant, but because he is its head and heart, and finds something of himself in every great and small thing, in every mountain stratum, in every new law of color, fact of astronomy, or atmospheric influence which observation or analysis lay open.

In the conditions of modern life the rule is absolute, the race which does not value trained intelligence is doomed. Not all your heroism, not all your social charm, not all your wit, not all your victories on land or at sea, can move back the finger of fate. To-day we maintain ourselves. To-morrow science will have moved forward yet one more step, and there will be no appeal from the judgment which will then be pronounced on the uneducated.

The astronomers said, 'Give us matter and a little motion and we will construct the universe. It is not enough that we should have matter, we must also have a single impulse, one shove to launch the mass and generate the harmony of the centrifugal and centripetal forces.' ... There is no end to the consequences of the act. That famous aboriginal push propagates itself through all the balls of the system, and through every atom of every ball.

Scientific and technological progress themselves are value-neutral. They are just very good at doing what they do. If you want to do selfish, greedy, intolerant and violent things, scientific technology will provide you with by far the most efficient way of doing so. But if you want to do good, to solve the world's problems, to progress in the best value-laden sense, once again, there is no better means to those ends than the scientific way.

Maybe I'm being a bit harsh on philosophers, but they have not been very kind to me... I have been variously called nominalist, an instrumentalist, a positivist, a realist, and several other ists. The technique seems refutation by denigration: If you can attach a label to my approach, you don't have to say what is wrong with it... I am sure that Einstein, Heisenberg and Dirac didn't worry about whether they were realists or instrumentalists.

Concerned to reconstruct past ideas, historians must approach the generation that held them as the anthropologist approaches an alien culture. They must, that is, be prepared at the start to find that natives speak a different language and map experience into different categories from those they themselves bring from home. And they must take as their object the discovery of those categories and the assimilation of the corresponding language.

We know enough to be sure that the scientific achievements of the next fifty years will be far greater, more rapid, and more surprising, than those we have already experienced. ... Wireless telephones and television, following naturally upon the their present path of development, would enable their owner to connect up to any room similarly equipped and hear and take part in the conversation as well as if he put his head in through the window.

The second [argument about motion] is the so-called Achilles, and it amounts to this, that in a race the quickest runner can never overtake the slowest, since the pursuer must first reach the point whence the pursued started, so that the slower must always hold a lead. Statement of the Achilles and the Tortoise paradox in the relation of the discrete to the continuous.; perhaps the earliest example of the reductio ad absurdum method of proof.

This is all very fine, but it won't do-Anatomy-botany-Nonsense! Sir, I know an old woman in Covent Garden, who understands botany better, and as for anatomy, my butcher can dissect a joint full as well; no, young man, all that is stuff; you must go to the bedside, it is there alone you can learn disease! Comment to Hans Sloane on Robert Boyle's letter of introduction describing Sloane as a 'ripe scholar, a good botanist, a skilful anatomist'.

The axioms of physics translate the laws of ethics. Thus, "the whole is greater than its part;" "reaction is equal to action;" "the smallest weight may be made to lift the greatest, the difference of weight being compensated by time;" and many the like propositions, which have an ethical as well as physical sense. These propositions have a much more extensive and universal sense when applied to human life, than when confined to technical use.

The first thing the intellect does with an object is to class it along with something else. But any object that is infinitely important to us and awakens our devotion feels to us also as if it must be sui generis and unique. Probably a crab would be filled with a sense of personal outrage if it could hear us class it without ado or apology as a crustacean, and thus dispose of it. 'I am no such thing,' it would say; 'I am MYSELF, MYSELF alone.

Evidence of this [transformation of animals into fossils] is that parts of aquatic animals and perhaps of naval gear are found in rock in hollows on mountains, which water no doubt deposited there enveloped in sticky mud, and which were prevented by coldness and dryness of the stone from petrifying completely. Very striking evidence of this kind is found in the stones of Paris, in which one very often meets round shells the shape of the moon.

The star [Tycho's supernova] was at first like Venus and Jupiter, giving pleasing effects; but as it then became like Mars, there will next come a period of wars, seditions, captivity and death of princes, and destruction of cities, together with dryness and fiery meteors in the air, pestilence, and venomous snakes. Lastly, the star became like Saturn, and there will finally come a time of want, death, imprisonment and all sorts of sad things.

I never got tired of watching the radar echo from an aircraft as it first appeared as a tiny blip in the noise on the cathode-ray tube, and then grew slowly into a big deflection as the aircraft came nearer. This strange new power to "see" things at great distances, through clouds or darkness, was a magical extension of our senses. It gave me the same thrill that I felt in the early days of radio when I first heard a voice coming out of a horn.

The enjoyments of elegant life you early chose to abandon, preferring to wander for many successive years over the rudest portions of Europe and Asia-regions new to Science-in the hope, happily realized, of winning new truths. By a rare union of favourable circumstances, and of personal qualifications equally rare, you have thus been enabled to become the recognized Interpreter and Historian (not without illustrious aid) of the Silurian Period.

Of Cooking. This is an art of various forms, the object of which is to give ordinary observations the appearance and character of those of the highest degree of accuracy. One of its numerous processes is to make multitudes of observations, and out of these to select only those which agree, or very nearly agree. If a hundred observations are made, the cook must be very unhappy if he cannot pick out fifteen or twenty which will do for serving up.

[When questioned on his longevity] First of all, I selected my ancestors very wisely. ... They were long-lived, healthy people. Then, as a chemist, I know how to eat, how to exercise, keep my blood circulating. ... I don't worry. I don't get angry at people. I don't worry about things I can't help. I do what I can to make the world a better place to live, but I don't complain if things aren't right. As a scientist I take the world as I find it.

The McCarthy period came along...and many of the other scientists who had been working on these same lines gave up. Probably saying "Why should I sacrifice myself? I am a scientist, I am supposed to be working on scientific things, so I don't need to put myself at risk by talking about these possibilities." And I have said that perhaps I'm just stubborn... I have said "I don't like anybody to tell me what to do or to think, except Mrs. Pauling."

For a billion years the patient earth amassed documents and inscribed them with signs and pictures which lay unnoticed and unused. Today, at last, they are waking up, because man has come to rouse them. Stones have begun to speak, because an ear is there to hear them. Layers become history and, released from the enchanted sleep of eternity, life's motley, never-ending dance rises out of the black depths of the past into the light of the present.

However the machine would permit us to test the hypothesis for any special value of n. We could carry out such tests for a sequence of consecutive values n=2,3,.. up to, say, n=100. If the result of at least one test were negative, the hypothesis would prove to be false; otherwise our confidence in the hypothesis would increase, and we should feel encouraged to attempt establishing the hypothesis, instead of trying to construct a counterexample.

A DNA sequence for the genome of bacteriophage ΦX174 of approximately 5,375 nucleotides has been determined using the rapid and simple 'plus and minus' method. The sequence identifies many of the features responsible for the production of the proteins of the nine known genes of the organism, including initiation and termination sites for the proteins and RNAs. Two pairs of genes are coded by the same region of DNA using different reading frames.

But when you come right down to it the reason that we did this job is because it was an organic necessity. If you are a scientist you cannot stop such a thing. If you are a scientist you believe that it is good to find out how the world works; that it is good to find out what the realities are; that it is good to turn over to mankind at large the greatest possible power to control the world and to deal with it according to its lights and values.

It is odd to think that there is a word for something which, strictly speaking, does not exist, namely, "rest." We distinguish between living and dead matter; between moving bodies and bodies at rest. This is a primitive point of view. What seems dead, a stone or the proverbial "door-nail," say, is actually forever in motion. We have merely become accustomed to judge by outward appearances; by the deceptive impressions we get through our senses.

I cannot but be astonished that Sarsi should persist in trying to prove by means of witnesses something that I may see for myself at any time by means of experiment. Witnesses are examined in doutbful matters which are past and transient, not in those which are actual and present. A judge must seek by means of witnesses to determine whether Peter injured John last night, but not whether John was injured, since the judge can see that for himself.

Richard Feynman was fond of giving the following advice on how to be a genius. You have to keep a dozen of your favorite problems constantly present in your mind, although by and large they will lay in a dormant state. Every time you hear or read a new trick or a new result, test it against each of your twelve problems to see whether it helps. Every once in a while there will be a hit, and people will say, "How did he do it? He must be a genius!"

I told him that for a modern scientist, practicing experimental research, the least that could be said, is that we do not know. But I felt that such a negative answer was only part of the truth. I told him that in this universe in which we live, unbounded in space, infinite in stored energy and, who knows, unlimited in time, the adequate and positive answer, according to my belief, is that this universe may, also, possess infinite potentialities.

Knox was engaged in a theological discussion with scientist John Scott Haldane. 'In a universe containing millions of planets,' reasoned Haldane, 'is it not inevitable that life should appear on at least one of them?' 'Sir,' replied Knox, 'if Scotland Yard found a body in your cabin trunk, would you tell them: 'There are millions of trunks in the world; surely one of them must contain a body? I think the would still want to know who put it there'.

Extinction has only separated groups: it has by no means made them; for if every form which has ever lived on this earth were suddenly to reappear, though it would be quite impossible to give definitions by which each group could be distinguished from other groups, as all would blend together by steps as fine as those between the finest existing varieties, nevertheless a natural classification, or at least a natural arrangement, would be possible.

But having considered everything which has been said, one could by this believe that the earth and not the heavens is so moved, and there is no evidence to the contrary. Nevertheless, this seems prima facie as much, or more, against natural reason as are all or several articles of our faith. Thus, that which I have said by way of diversion (esbatement) in this manner can be valuable to refute and check those who would impugn our faith by argument.

The next decade will perhaps raise us a step above despair to a cleaner, clearer wisdom and biology cannot fail to help in this. As we become increasingly aware of the ethical problems raised by science and technology, the frontiers between the biological and social sciences are clearly of critical importance-in population density and problems of hunger, psychological stress, pollution of the air and water and exhaustion of irreplaceable resources.

Through it [Science] we believe that man will be saved from misery and degradation, not merely acquiring new material powers, but learning to use and to guide his life with understanding. Through Science he will be freed from the fetters of superstition; through faith in Science he will acquire a new and enduring delight in the exercise of his capacities; he will gain a zest and interest in life such as the present phase of culture fails to supply.

I will now direct the attention of scientists to a previously unnoticed cause which brings about the metamorphosis and decomposition phenomena which are usually called decay, putrefaction, rotting, fermentation and moldering. This cause is the ability possessed by a body engaged in decomposition or combination, i.e. in chemical action, to give rise in a body in contact with it the same ability to undergo the same change which it experiences itself.

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