We must not forget that when radium was discovered no one knew that it would prove useful in hospitals. The work was one of pure science. And this is a proof that scientific work must not be considered from the point of view of the direct usefulness of it. It must be done for itself, for the beauty of science, and then there is always the chance that a scientific discovery may become like the radium a benefit for humanity.

Science is the century-old endeavour to bring together by means of systematic thought the perceptible phenomena of this world into as thorough-going an association as possible. To put it boldly, it is the attempt at a posterior reconstruction of existence by the process of conceptualization. Science can only ascertain what is, but not what should be, and outside of its domain value judgements of all kinds remain necessary.

Almost everyone... seems to be quite sure that the differences between the methodologies of history and of the natural sciences are vast. For, we are assured, it is well known that in the natural sciences we start from observation and proceed by induction to theory. And is it not obvious that in history we proceed very differently? Yes, I agree that we proceed very differently. But we do so in the natural sciences as well.

It is a right, yes a duty, to search in cautious manner for the numbers, sizes, and weights, the norms for everything [God] has created. For He himself has let man take part in the knowledge of these things ... For these secrets are not of the kind whose research should be forbidden; rather they are set before our eyes like a mirror so that by examining them we observe to some extent the goodness and wisdom of the Creator.

...mathematics is distinguished from all other sciences except only ethics, in standing in no need of ethics. Every other science, even logic, especially in its early stages, is in danger of evaporating into airy nothingness, degenerating, as the Germans say, into an arachnoid film, spun from the stuff that dreams are made of. There is no such danger for pure mathematics; for that is precisely what mathematics ought to be.

The world is not as it was when it came from its Maker's hands. It has been modified by many great revolutions, brought about by an inner mechanism of which we very imperfectly comprehend the movements; but of which we gain a glimpse by studying their effects: and their many causes still acting on the surface of our globe with undiminished power, which are changing, and will continue to change it, as long as it shall last.

No one has yet been found so firm of mind and purpose as resolutely to compel himself to sweep away all theories and common notions, and to apply the understanding, thus made fair and even, to a fresh examination of particulars. Thus it happens that human knowledge, as we have it, is a mere medley and ill-digested mass, made up of much credulity and much accident, and also of the childish notions which we at first imbibed.

In describing the honourable mission I charged him with, M. Pernety informed me that he made my name known to you. This leads me to confess that I am not as completely unknown to you as you might believe, but that fearing the ridicule attached to a female scientist, I have previously taken the name of M. LeBlanc in communicating to you those notes that, no doubt, do not deserve the indulgence with which you have responded.

It is not always the most brilliant speculations nor the choice of the most exotic materials that is most profitable. I prefer Monsieur de Reaumur busy exterminating moths by means of an oily fleece; or increasing fowl production by making them hatch without the help of their mothers, than Monsieur Bemouilli absorbed in algebra, or Monsieur Leibniz calculating the various advantages and disadvantages of the possible worlds.

In trying to evaluate Hopkins' unique contribution to biochemistry it may perhaps be said that he alone amongst his contemporaries succeeded in formulating the subject. Among others whose several achievements in their own fields may have surpassed his, no one has ever attempted to unify and correlate biochemical knowledge so as to form a comprehensible picture of the cell and its relation to life, reproduction and function.

...a man estimable for his learning, amiable for his life, and venerable for his piety. Arbuthnot was a man of great comprehension, skilful in his profession, versed in the sciences, acquainted with ancient literature, and able to animate his mass of knowledge by a bright and active imagination; a scholar with great brilliance of wit; a wit who, in the crowd of life, retained and discovered a noble ardour of religious zeal.

So says the most ancient book of the Earth; thus it is written on its leaves of marble, lime, sand, slate, and clay: ... that our Earth has fashioned itself, from its chaos of substances and powers, through the animating warmth of the creative spirit, to a peculiar and original whole, by a series of preparatory revolutions, till at last the crown of its creation, the exquisite and tender creature man, was enabled to appear.

Hardly a pure science, history is closer to animal husbandry than it is to mathematics in that it involves selective breeding. The principal difference between the husbandryman and the historian is that the former breeds sheep or cows or such and the latter breeds (assumed) facts. The husbandryman uses his skills to enrich the future, the historian uses his to enrich the past. Both are usually up to their ankles in bullshit.

There is not enough evidence, consistent evidence to make it as fact, and I say that because for theory to become a fact, it needs to consistently have the same results after it goes through a series of tests. The tests that they put- that they use to support evolution do not have consistent results. Now too many people are blindly accepting evolution as fact. But when you get down to the hard evidence, it's merely a theory.

It is to them [fossils] alone that we owe the commencement of even a Theory of the Earth ... By them we are enabled to ascertain, with the utmost certainty, that our earth has not always been covered over by the same external crust, because we are thoroughly assured that the organized bodies to which these fossil remains belong must have lived upon the surface before they came to be buried, as they now are, at a great depth.

In the following pages I offer nothing more than simple facts, plain arguments, and common sense; and have no other preliminaries to settle with the reader, than that he will divest himself of prejudice and repossession, and suffer his reason and feelings to determine for themselves; and that he will put on, or rather that he will not put off, the true character of man, and generously enlarge his view beyond the present day.

I do not think that G. H. Hardy was talking nonsense when he insisted that the mathematician was discovering rather than creating, nor was it wholly nonsense for Kepler to exult that he was thinking God's thoughts after him. The world for me is a necessary system, and in the degree to which the thinker can surrender his thought to that system and follow it, he is in a sense participating in that which is timeless or eternal.

The first man who said "fire burns" was employing scientific method, at any rate if he had allowed himself to be burnt several times. This man had already passed through the two stages of observation and generalization. He had not, however, what scientific technique demands - a careful choice of significant facts on the one hand, and, on the other hand, various means of arriving at laws otherwise than my mere generalization.

The laws expressing the relations between energy and matter are, however, not solely of importance in pure science. They necessarily come first in order ... in the whole record of human experience, and they control, in the last resort, the rise or fall of political systems, the freedom or bondage of nations, the movements of commerce and industry, the origin of wealth and poverty, and the general physical welfare of the race.

I myself, a professional mathematician, on re-reading my own work find it strains my mental powers to recall to mind from the figures the meanings of the demonstrations, meanings which I myself originally put into the figures and the text from my mind. But when I attempt to remedy the obscurity of the material by putting in extra words, I see myself falling into the opposite fault of becoming chatty in something mathematical.

In the years since man unlocked the power stored up within the atom, the world has made progress, halting, but effective, toward bringing that power under human control. The challenge may be our salvation. As we begin to master the destructive potentialities of modern science, we move toward a new era in which science can fulfill its creative promise and help bring into existence the happiest society the world has ever known.

Haemoglobin is a very large molecule by ordinary standards, containing about ten thousand atoms, but the chances are that your haemoglobin and mine are identical, and significantly different from that of a pig or horse. You may be impressed by how much human beings differ from one another, but if you were to look into the fine details of the molecules of which they are constructed, you would be astonished by their similarity.

Buffon, who, with all his theoretical ingenuity and extraordinary eloquence, I suspect had little actual information in the science on which he wrote so admirably For instance, he tells us that the cow sheds her horns every two years; a most palpable error. ... It is wonderful that Buffon who lived so much in the country at his noble seat should have fallen into such a blunder I suppose he has confounded the cow with the deer.

If someone points out to you that your pet theory of the universe is in disagreement with Maxwell's equations - then so much the worse for Maxwell's equations. If it is found to be contradicted by observation - well, these experimentalists do bungle things sometimes. But if your theory is found to be against the second law of thermodynamics I can give you no hope; there is nothing for it but to collapse in deepest humiliation.

My favourite fellow of the Royal Society is the Reverend Thomas Bayes, an obscure 18th-century Kent clergyman and a brilliant mathematician who devised a complex equation known as the Bayes theorem, which can be used to work out probability distributions. It had no practical application in his lifetime, but today, thanks to computers, is routinely used in the modelling of climate change, astrophysics and stock-market analysis.

Whether or not you agree that trimming and cooking are likely to lead on to downright forgery, there is little to support the argument that trimming and cooking are less reprehensible and more forgivable. Whatever the rationalization is, in the last analysis one can no more than be a bit dishonest than one can be a little bit pregnant. Commit any of these three sins and your scientific career is in jeopardy and deserves to be.

I think that we shall have to get accustomed to the idea that we must not look upon science as a 'body of knowledge,' but rather as a system of hypotheses; that is to say, as a system of guesses or anticipations which in principle cannot be justified, but with which we work as long as they stand up to tests, and of which we are never justified in saying that we know they are 'true' or 'more or less certain' or even 'probable.'

You will be astonished when I tell you what this curious play of carbon amounts to. A candle will burn some four, five, six, or seven hours. What, then, must be the daily amount of carbon going up into the air in the way of carbonic acid! ... Then what becomes of it? Wonderful is it to find that the change produced by respiration ... is the very life and support of plants and vegetables that grow upon the surface of the earth.

Much of the geographical work of the past hundred years... has either explicitly or implicitly taken its inspiration from biology, and in particular Darwin. Many of the original Darwinians, such as Hooker, Wallace, Huxley, Bates, and Darwin himself, were actively concerned with geographical exploration, and it was largely facts of geographical distribution in a spatial setting which provided Darwin with the germ of his theory.

The development doctrines are doing much harm on both sides of the Atlantic, especially among intelligent mechanics, and a class of young men engaged in the subordinate departments of trade and the law. And the harm, thus considerable in amount, must be necessarily more than merely considerable in degree. For it invariably happens, that when persons in these walks become materialists, they become turbulent subjects and bad men.

Imagine a school-boy who has outgrown his clothes. Imagine the repairs made on the vestments where the enlarged frame had burst the narrow limits of its inclosure. Imagine the additions made where the projecting limbs had fairly and far emerged beyond the confines of the garment. Imagine the boy still growing, and the clothes, mended all over, now more than ever in want of mending - such is chemistry, and such its nomenclature.

There are fewer chemical pollutants in the air. Our drinking water is safer. Our food standards have been raised. We've cleaned up more toxic waste sites in three years than the previous administrations did in twelve. The environment is cleaner, and we have fought off the most vigorous assault on environmental protection since we began to protect the environment in 1970. We are moving in the right direction to the 21st century.

There is only one law of Nature-the second law of thermodynamics-which recognises a distinction between past and future more profound than the difference of plus and minus. It stands aloof from all the rest. ... It opens up a new province of knowledge, namely, the study of organisation; and it is in connection with organisation that a direction of time-flow and a distinction between doing and undoing appears for the first time.

With a thousand joys I would accept a nonacademic job for which industriousness, accuracy, loyalty, and such are sufficient without specialized knowledge, and which would give a comfortable living and sufficient leisure, in order to sacrifice to my gods [mathematical research]. For example, I hope to get the editting of the census, the birth and death lists in local districts, not as a job, but for my pleasure and satisfaction.

A multidisciplinary study group ... estimated that it would be 1980 before developments in artificial intelligence make it possible for machines alone to do much thinking or problem solving of military significance. That would leave, say, five years to develop man-computer symbiosis and 15 years to use it. The 15 may be 10 or 500, but those years should be intellectually the most creative and exciting in the history of mankind.

It is unreasonable to expect science to produce a system of ethics-ethics are a kind of highway code for traffic among mankind-and the fact that in physics atoms which were yesterday assumed to be square are now assumed to be round is exploited with unjustified tendentiousness by all who are hungry for faith; so long as physics extends our dominion over nature, these changes ought to be a matter of complete indifference to you.

If you want to find out anything from the theoretical physicists about the methods they use, I advise you to stick closely to one principle: don't listen to their words, fix your attention on their deeds. To him who is a discoverer in this field the products of his imagination appear so necessary and natural that he regards them, and would like to have them regarded by others, not as creations of thought but as given realities.

Science is the only truth and it is the great lie. It knows nothing, and people think it knows everything. It is misrepresented. People think that science is electricity, automobilism, and dirigible balloons. It is something very different. It is life devouring itself. It is the sensibility transformed into intelligence. It is the need to know stifling the need to live. It is the genius of knowledge vivisecting the vital genius.

Feynman's cryptic remark, "no one is that much smarter ...," to me, implies something Feynman kept emphasizing: that the key to his achievements was not anything "magical" but the right attitude, the focus on nature's reality, the focus on asking the right questions, the willingness to try (and to discard) unconventional answers, the sensitive ear for phoniness, self-deception, bombast, and conventional but unproven assumptions.

[May] this civic and social landmark [the Washington, D.C., Jewish Community Center] ... be a constant reminder of the inspiring service that has been rendered to civilization by men and women of the Jewish faith. May [visitors] recall the long array of those who have been eminent in statecraft, in science, in literature, in art, in the professions, in business, in finance, in philanthropy and in the spiritual life of the world.

Da Vinci was as great a mechanic and inventor as were Newton and his friends. Yet a glance at his notebooks shows us that what fascinated him about nature was its variety, its infinite adaptability, the fitness and the individuality of all its parts. By contrast what made astronomy a pleasure to Newton was its unity, its singleness, its model of a nature in which the diversified parts were mere disguises for the same blank atoms.

The errors of a wise man are literally more instructive than the truths of a fool. The wise man travels in lofty, far-seeing regions; the fool in low-lying, high-fenced lanes; retracing the footsteps of the former, to discover where he diviated, whole provinces of the universe are laid open to us; in the path of the latter, granting even that he has not deviated at all, little is laid open to us but two wheel-ruts and two hedges.

The puritanical potentialities of science have never been forecast. If it evolves a body of organized rites, and is established as a religion, hierarchically organized, things more than anything else will be done in the name of 'decency.' The coarse fumes of tobacco and liquors, the consequent tainting of the breath and staining of white fingers and teeth, which is so offensive to many women, will be the first things attended to.

The advance of science is not comparable to the changes of a city, where old edifices are pitilessly torn down to give place to new, but to the continuous evolution of zoologic types which develop ceaselessly and end by becoming unrecognisable to the common sight, but where an expert eye finds always traces of the prior work of the centuries past. One must not think then that the old-fashioned theories have been sterile and vain.

For these two years I have been gravitating towards your doctrines, and since the publication of your primula paper with accelerated velocity. By about this time next year I expect to have shot past you, and to find you pitching into me for being more Darwinian than yourself. However, you have set me going, and must just take the consequences, for I warn you I will stop at no point so long as clear reasoning will take me further.

We might expect intelligent life and technological communities to have emerged in the universe billions of years ago. Given that human society is only a few thousand years old, and that human technological society is mere centuries old, the nature of a community with millions or even billions of years of technological and social progress cannot even be imagined. ... What would we make of a billion-year-old technological community?

From this time everything was copulated. Acetic, formic, butyric, margaric, &c., acids, alkaloids, ethers, amides, anilides, all became copulated bodies. So that to make acetanilide, for example, they no longer employed acetic acid and aniline, but they re-copulated a copulated oxalic acid with a copulated ammonia. I am inventing nothing-altering nothing. Is it my fault if, when writing history, I appear to be composing a romance?

Geological facts being of an historical nature, all attempts to deduce a complete knowledge of them merely from their still, subsisting consequences, to the exclusion of unexceptionable testimony, must be deemed as absurd as that of deducing the history of ancient Rome solely from the medals or other monuments of antiquity it still exhibits, or the scattered ruins of its empire, to the exclusion of a Livy, a Sallust, or a Tacitus.

It would appear... that moral phenomena, when observed on a great scale, are found to resemble physical phenomena; and we thus arrive, in inquiries of this kind, at the fundamental principle, that the greater the number of individuals observed, the more do individual peculiarities, whether physical or moral, become effaced, and leave in a prominent point of view the general facts, by virtue of which society exists and is preserved.

A theory is the more impressive the greater the simplicity of its premises is, the more different kinds of things it relates, and the more extended is its area of applicability. Therefore the deep impression which classical thermodynamics made upon me. It is the only physical theory of universal content concerning which I am convinced that within the framework of the applicability of its basic concepts, it will never be overthrown.

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