One of the first papers I wrote at the University of Wisconsin, in 1977, was on stem cells. I realized that if I changed the environment that these cells were in, I could turn the cells into bone, and if I changed the environment a bit more, they would form fat cells.

I spent my 20s earning minimum wage decorating cakes for a living. But one day, I looked in the mirror and realized I wanted more, for me and my people. I saw too many Native Americans struggling, and I realized we should have a voice in who our elected officials are.

I've never been a frustrated person because I learnt at a very young age that the frustration I had inside of me had to do with creativity and the ability to transform that into action. I realized very early my restlessness had to be channelled into things I could do.

The drawings in 'Portal' were actually me scribbling that stuff... I had a funny moment when I realized that someone gotten 'The cake is a lie' tattooed on themselves. It was really interesting to see my handwriting tattooed on another human being. That... that's odd.

My mom has an English accent, so we always referred to the trunk as the 'boot.' And then, suddenly, we moved to Georgia and I would say things like 'open the boot' with a bit of an accent, and I quickly realized I had to adapt; that kind of thing will get you beat up!

I mean simply to say that I want my characters to suggest the background in themselves, even when it is not visible. I want them to be so powerfully realized that we cannot imagine them apart from their physical and social context even when we see them in empty space.

Larry Kramer wisely realized so early on that to change the world, people have to know you. If they know you and see that we are all the same - that we all have normal hearts - that's the first step. I'm both amazed at the progress and amazed at how far we have to go.

I know that sounds selfish, but you have to look at what it's doing to you personally - are you frustrated because of the way people perceive you, or are you happy enough about the things you've realized about yourself that you can tolerate the way people perceive you?

I realized I was gay in the shower one day with Barbra Streisand. It happened while I was lathering, rinsing, and repeating with Pert Plus. As I was belting out the chorus to my favorite song from 'Funny Girl,' 'Oh my man, I love him so, he'll never know...' it hit me.

Inequality brings a visceral reaction. We fought many years to bring others to believe in what was possible with women's soccer, in this country and globally. Now that the possible is being realized in this country, the American women should be compensated accordingly.

The funniest thing is I never understood why actors were so shady about who they're dating. Then I realized the things you say get printed and the people you're involved with read them. That's what's tricky. Nothing goes unnoticed. I don't want to get myself in trouble!

When I realized I wanted to do more writing and less traveling around the world teaching live seminars, I decided to write the first 'Chicken Soup for the Soul(R)' book. I knew I wanted to have 100 stories in the book, so I wrote or edited two stories a week for a year.

I grew up with an Italian family in an era when a woman's path was laid out for her: You got married and had children. Simple, right? Then I got to a point around the age of 30 when I had three little children and was a single mom, and I realized life was not so simple.

What I realized is that it doesn't matter how big or small your film is. The actual filmmaking process, the actual storytelling, it's still the same thing. It's still all about creating characters that you like and creating moments that get you excited or get you tense.

I was, like, forty at birth. When I wasn't even a year old, I spoke, I was potty trained, I walked and talked. That was it. Then I started school and drove everybody crazy because they realized I had popped out as an adult. I had adult questions and wanted adult answers.

When I heard 'Moon River', at first I thought it was just a nice song, but then I started paying attention to the words and realized this song was about Huck Finn. I just love the words, that it's kind of you and me against the world, and we're going to make it together.

When 'American Born Chinese' started getting a lot of attention, I freaked out a little bit because I realized that up until then I had just been doing comics by following my gut. I didn't really know much about plot structure or anything; I kind of just followed my gut.

I kind of got more interested in writing after I turned in my last college essay and nobody was going to tell me what kind of academic papers to write anymore. I could write whatever I wanted, and I realized that I actually liked it when I could choose what I would write.

I realized going back and writing and explaining in details the difficulties I had lived actually became emotional again. It's like therapy but sometimes therapy can be painful. But it's part of life and part of the autobiography so I'll have to finish it sooner or later.

In the early days of Twitter, it was like a place of radical de-shaming. People would admit shameful secrets about themselves, and other people would say, 'Oh my God, I'm exactly the same.' Voiceless people realized that they had a voice, and it was powerful and eloquent.

When I got traded to the California Angels, I really wasn't that excited about going to the Angels because it meant changing leagues and also a whole new set of teammates. But shortly after I got there I realized that it was one of the best things that ever happened to me.

I'm a huge stadium rock fan, but I'm also a fan of everything from Massive Attack to Peter Gabriel, U2, the Police, Radiohead, and Coldplay. I've realized that I love all forms of music and get excited when any artist goes crazy and creates something that is an experience.

I started using Twitter a lot and realized I had a lot of fans. Then I saw that I can share my music on Twitter and share my YouTube videos on Twitter. That's how I knew social media was going to be a platform to show my music. That's how I started. I started with Twitter.

The HoLee model was the first term structure model. I remember reading their paper soon after it was published and as it was fairly different from many of the other papers that I had read, I had to read it quite a few times. I realized that it was a really important paper.

The other work we started in 1992, it is called Over the River, Project for the Arkansas River in the state of Colorado, we haven't got the permit yet. And, we are working at both of those, trying to get the permit. Therefore, we do not know which one will be realized next.

Personally, getting into college was a big deal because I realized it's probably one of the only things I've fully planned. The rest of my life has been, for the most part, a nice little happy accident. I'm glad that it happened this way, but it's nonetheless unintentional.

Since many years, I realized that I have a darker side in me, even though I still believe I'm a very positive person. But still, there is still darkness that makes me write music and create in general, and it affects everything that I do. I believe it's a beautiful darkness.

In 1978, the first flag was organic everything. It did have eight colors: the six colors of the rainbow we see today plus hot pink and turquoise. But pretty quickly on I realized that I would never be able to satisfy the demand for them by hand-dying fabric and these colors.

I always knew I had a voice and I've always known I could sing, but I was too shy to let it come out. I think it's the hardest thing to do, to sing in front of people. When I finally let go and did it, I realized it's what I'm most talented at and what I love to do the most.

First, I was opposed to gay marriage because it seemed like one more way that gays were wanting to assimilate. When I realized the Christian right was so opposed to it, as well as tyrannical governments in Africa and Russia, I thought, 'It must be a good thing to fight for.'

I suddenly realized that the fellow who didn't show up was getting about fifty-times more money than I was getting. So I thought, 'this is silly,' and became an actor. I certainly never thought I'd wind up in motion pictures. That was far beyond anything I'd ever dreamed of.

I didn't care about that because I'm not a diplomatic person to begin with. I just went along with things and did what I wanted to do because I knew they had to shoot their 12 pages a day. And when they realized that I didn't alter the text they really didn't mind what I did.

I wanted to be a writer as a teen... so storytelling was my first love. In my late teens, design became an obsession as I realized that I could express myself through the medium. Much later, when I founded Fuseproject in 1999, our slogan became 'design brings stories to life.'

When I was 12, we began hosting exchange students from Norway, Sweden, Japan and Spain. I soon realized there was a whole world out there. I was determined to spend my sophomore year in high school abroad. My school taught only Spanish, but I wanted to go to France, and I did.

After 2012, I thought, 'Oh wow, I've lived through this, and now I have a free ride in life.' And I can't believe I really thought that. As soon as I was healed from cancer and everything I was going through, I got back out into life and realized it doesn't work out like that.

I played several maids in my career. I was tired of the maid after 'Far From Heaven.' I said, no more maids. Until I realized how difficult it was to get a role other than a maid, sometimes, in Hollywood, and sometimes you have to choose your battles, for lack of a better term.

I was just so focused on being healthy for my baby during pregnancy, and afterward I was not in a rush to lose the weight. I really wanted to be as healthy as I could. It wasn't about getting my six-pack back. There are more important things in life than a six-pack, I realized.

Autobiography is awfully seductive; it's wonderful. Once I got into it, I realized I was following a tradition established by Frederick Douglass - the slave narrative - speaking in the first-person singular, talking about the first-person plural, always saying 'I,' meaning 'we.'

I think, the first time I played Iago at the Public Theater, I realized I had a - much to my chagrin - I realized I had an instinct for these conflicted characters, for these torn characters, for these characters who could be described as evil. I wouldn't describe them that way.

I've realized that although Valentine's Day can be a cheesy money-making stint to most people, it's a day of expressing love across the world. It doesn't have to only be between lovers, but by telling a friend that you care, or even an old person that they are still appreciated.

When I was 18 or 19, I realized that everything I was doing was connected to music - writing, doing videos, making my clothes. It all centered around being an artist. So I released a mixtape that I made in my bedroom, and it ended up getting a lot more attention than I expected.

In 1975, which was the height of the women's movement, I thought I'd write a book on women's history. But in searching for a topic, I realized that there were few places in history where men and women interacted. Finally, it hit me: 'Oh, look at the family. That's the one place.'

I went to UCLA and studied studio art. I thought I was going to be a gallery painter, photographer, or ceramicist. Then, when I graduated, that didn't happen immediately. I didn't suddenly get solo shows in Chelsea, and I realized that is actually kind of difficult to break into.

'The Immigrant Story,' which took me about twenty-five years to write, was a very simple story, but I couldn't think of how to tell it. Then twenty years after I started it, I found this one page and realized it was going to be the story. That's the only way you get it sometimes.

I'm not saying anything to denigrate 'Criminal Minds'; that's a great show. I just didn't appreciate it anymore. I appreciate those people, but I realized my heart wasn't in and I needed to go because plenty of people would rip their arm off to be on that show, so they should be.

The American society around me looked at me and saw Japanese. Then, when I was 19, I went to Japan for the first time. And suddenly - what a shock - I realized I wasn't Japanese; they saw me as American. It was an enormous relief. Now I just appreciate being exactly in the middle.

What I realized the moment I got to Oxford was that someone like me could not really be part of it. I mean, I could make a success there, I could even be perhaps accepted into it, but I would never feel it was my place. It's the summit of something else. It's distilled Englishness.

Over a period of time, if you have a successful show, then you have a devoted audience. I feel you owe something to them. That goes for everybody - writers, camera operators, actors, studio executives, etc. Sadly, I've realized it's a responsibility that very few people live up to.

Growing up, if I had been given any advice - bad or good - I probably wouldn't have been able to act on it regardless. I wasn't shy, but I'd get nervous. I got a little more confident later in high school when I realized I could get girls to pay attention to me by making them laugh.

We spend billions on international aid annually, but we don't find ways to connect people to dignified work. I realized that if we don't think about ways to harness private capital to solve problems, we're leaving large amounts of money on the table and doing ourselves a disservice.

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