Autoimmunity is probably the next frontier. The majority of cases of autoimmune disease result from a complex genetic problem that has environmental influences. It is a colossal task for the immune system to maintain tolerance to self and yet be ready to react to everything in the world around us.

I don't hold with shamans, witch doctors, or psychiatrists. Shakespeare, Tolstoy, or even Dickens, understood more about the human condition than ever occurred to any of you. You overrated bunch of charlatans deal with the grammar of human problems, and the writers I've mentioned with the essence.

I think part of the problem with charity is that it tends to make us view people as helpless victims. I think in the future, we'll look back on charity in the same way that we look back on colonialism today: as a very paternalistic system that doesn't fully recognise the full spectrum of humanity.

There are lots of problems in Transnet, which we are trying to sort out, but we are quite confident we will. We can't avoid the increase in the capacity of Spoornet. So, whatever problems there are in Spoornet, they must be solved. The same goes for the harbours. And the same goes for the airlines.

Maybe it's stress or anger or adrenaline or disillusionment or a bullying nature or simple fear of getting killed themselves, but there is a problem if a cop cannot tell the difference between a menacing gangster and the far more common person they encounter whose life is a little frayed and messy.

This is what people don't understand: obesity is a symptom of poverty. It's not a lifestyle choice where people are just eating and not exercising. It's because kids - and this is the problem with school lunch right now - are getting sugar, fat, empty calories - lots of calories - but no nutrition.

Well, at the time, we certainly regarded them [Elianor and Franklin Roosevelt] as partners. We did not know what has since come out about the difficulties of their marital life, or the problems that Franklin gave Eleanor and his mother gave Eleanor, in many respects. We didn't know much about that.

The problem with dragons is that everyone uses them. All the time. When that happens, they become commonplace. A lot of people think you can just throw them into a story and suddenly whatever you're writing is 28% cooler. But that doesn't work. All that does is make dragons into some boring cliche.

One problem I have with faith-healing is that it tends to be focused only on the physical aspect of healing. But Jesus always backed away when people came to him only to get their physical needs met. My goodness, he was ready to have you lop off your hand! His real interest was in healing the soul.

I took a computer-science course to fill a prerequisite at Stanford, and I realized that every day was a new problem, and every day you got to think about how to solve something new, how to reason through something new, how to develop an algorithm to solve for something you hadn't worked on before.

One of the greatest problems that money creates is that you never know whether you are loved or your money is loved, whether you are desirable or your money is desirable. And it is so difficult to figure out, that one would have preferred not to have had money; at least life would have been simple.

So the only problem that you have is actually switch things in the department, changing things, controlling things, putting it maybe under federal supervision, and if you fix the department, you'll fix the problems - with police corruption, with brutality, with evidence tampering, all those things.

It's paradoxical that, when you have better health, families choose to have less children, because they've been having enough children so that they can be sure that a few of them will survive and take care of them. So as health improves, then all the other problems are dramatically easier to tackle.

Military is a great place for a jock. That's the first thing they test you, they test you physically. If you can run, if you can do the pushups, it's not as hard a transition. If you can't do that, you're going to have a problem because they're going to really work it out of you or work it into you.

I believe that the financial crisis of 2008/9 exposed more a lack of ethics and morality - especially by the financial sector - rather than a problem of regulation or criminality. There were, of course, regulatory lessons to be learned, but at heart, there was a collective loss of our moral compass.

Saving our planet, lifting people out of poverty, advancing economic growth... these are one and the same fight. We must connect the dots between climate change, water scarcity, energy shortages, global health, food security and women's empowerment. Solutions to one problem must be solutions for all.

The problem of different sensitivities of distinct protein groups to lysosomal inhibitors has remained unsolved and may have served as an important trigger in the future quest for a non-lysosomal proteolytic system that may be involved in at least certain aspects of intracellular protein degradation.

My new long anhyzer disc and controlled fairway driver. It gets the same beautiful flippy hyzer S shot as my Surge, I just don't have to throw it as hard. This makes it the most valuable to me on uncertain terrain where my footwork is compromised. A stand-still driver shot is now no longer a problem.

Since scarcity is the basic economic problem, if it does not exist then there is no reason for my economics course. Devoting time to the study of how people use limited resources to fulfill unlimited wants and needs should help us to discover how to best utilize the resources we have at our disposal.

If you attack a mathematical problem directly, very often you come to a dead end, nothing you do seems to work and you feel that if only you could peer round the corner there might be an easy solution. There is nothing like having somebody else beside you, because he can usually peer round the corner.

That's the problem with relationships, It's a contract. You agree to be some unchanging caricature of yourself. To act the same way all the time. Never to change. It's counter-evolutionary. How can anything new and good come into your life, if you're holding on to something that doesn't exist anymore?

I love essential oils - there's one for every problem. It's kind of like nature's answers for what to put on your skin. I had acne when I was a teenager, and I did a pretty intense tea tree thing. You dilute it in a base oil, like carrot seed oil, which is good because it gives your face a little glow.

The problem with feminism in the second wave was that we fought so much among ourselves, and I think we did so much damage to the movement... and I think the next wave, the third wave, is women mentoring younger women and women helping younger women to enter the political process and the writing world.

I see the main problem as a spiritual one, not a resource problem, or a problem with this or that government, but a larger problem centered around human beliefs, the troublesome elements founded in our mythology. Our problematic mythology is collapsing all around us. It is a mythology that is predatory.

There is a huge need and a huge opportunity to get everyone in the world connected, to give everyone a voice and to help transform society for the future. The scale of the technology and infrastructure that must be built is unprecedented, and we believe this is the most important problem we can focus on.

FBI directors serve at the pleasure of the president, but they often have terms that transcend partisan transfers of power at the White House. Firing an FBI director is a major problem from the point of view of a president who is already facing significant questions about investigations already underway.

Thank God, I have sort of a pan-European accent rather than Russian, which doesn't sound very pleasantly to Americans. For them, we speak with a rather rude pitch, and that might be our actors' problem there. Now I've begun working with language coaches in Los Angeles to get rid of the accent completely.

The problem with modern politics is everybody is doing sound bite stuff. In my stump speech, I give 20 minutes on why I think we're off track. And I think people do really want to engage in a serious high-level discussion on how to get the country back on track because people care about their own country.

Too-easy credit and millions of bad loans made during the U.S. housing bubble paved the way for the financial calamity and Great Recession that followed. Today, by contrast, credit is too tight. Mortgage loans are particularly hard to get, creating a problem for the housing market and the broader economy.

In 'The Sound of Music,' I was a von Trapp daughter in a white dress with a blue satin sash, and my line was, 'I'm Brigitta. I'm 12, and all I want is a good time.' I got a laugh. And I was so delighted, I laughed, too. Sadly, that's a problem I still have - onstage, I laugh hysterically at how funny I am.

The opportunities and threats existing in any situation always exceed the resources needed to exploit the opportunities or avoid the threats. Thus, strategy is essentially a problem of allocating resources. If strategy is to be successful, it must allocate superior resources against a decisive opportunity.

The person who lets them get you down, any kind of problem, is the person that fades out. So you've got to be strong enough; you don't like it, but you've got to be strong enough to accept what's going on and that you're going to fight it or whatever it takes to overcome this matter. That's the way I feel.

The northern border is a different problem set than our southern border. We're not going to put a fence between America and Canada, across Glacier Park. I grew up there. We can use some technological controls. We work with the Canadians more, and there's a lot of property we share, along with tribal lands.

For much of Toyota's history, we have ensured the quality and reliability of our vehicles by placing a device called an andon cord on every production line - and empowering any team member to halt production if there's an assembly problem. Only when the problem is resolved does the line begin to move again.

Without getting into brothels, there are ethical capitalists the problem is that there aren't enough of them. It is not "just a few bad apples" that have been evident in our corporations, our investment bankers and our mutual funds, but so many that one has to concede that the barrel itself needs some work.

The problem with basing weapons sales on strategic interest is that these interests tend to shift over time, while weapons are durable goods that do not evaporate as quickly as some alliances do. Once supplied, they can't be taken back. That leads to situations such as the ones we have seen in Iraq, Somalia.

Bottom line, I removed myself from the victim mentality and took control of my life. I'm not just going to take responsibility for the success in my life - I'm going to take responsibility for the failures in my life. When you're willing to accept that you're the problem, you immediately become the solution.

We must learn to outgrow our egos in exchange for constructive dialogue rather than debate. In addition, we must be capable of stating problems and proposing solutions clearly and succinctly, without distortion of meaning or misunderstanding, even when these solutions are radically opposed to accepted norms.

It is not, of course, complete yet - but some sentences were understood this afternoon... I feel that I have at last struck the solution of a great problem - and the day is coming when telegraph wires will be laid onto houses just like water or gas - and friends converse with each other without leaving home.

It wasn't until last year that I figured out the problem: I just don't love competitive golf. What I love is the game itself. I love being outdoors, practicing, and smelling the freshly cut grass at 6:00 a.m. as the sun rises. But I didn't love travel, or pressure, or the mean-spiritedness of my competitors.

Biggest problem? Well, I'd say it's been my biggest problem all my life. MONEY. It takes a lot of money to make these dreams come true. From the very start it was a problem. Getting the money to open Disneyland. About seventeen million it took. And we had everything mortgaged including my personal insurance.

Any time scientists disagree, it's because we have insufficient data. Then we can agree on what kind of data to get; we get the data; and the data solves the problem. Either I'm right, or you're right, or we're both wrong. And we move on. That kind of conflict resolution does not exist in politics or religion.

Most firms are hierarchical in nature, with everyone getting different slices of the economic pie. The problem is those slices are negotiated every time a firm raises a new fund, so in between funds, which is most of the time, the partners are trying to outgun one another to make a stronger case for themselves.

I think the issue that millennials have is that the return on asset classes such as bonds, cash, are so low now compared to the historical levels that it's very difficult for them to save enough to be able to retire comfortably. If interest rates do trend back upwards, it may be less of a problem going forward.

Climate change and ozone depletion are two global issues that are different but have many connections. In the ozone depletion case, we managed to work with decision makers effectively so that an international agreement called the Montreal Protocol was achieved that essentially solved the ozone depletion problem.

Money has always been a particular problem for revolutionaries and anti-capitalists. What will money look like 'after the revolution'? How will it function? Will it exist at all? It's hard to answer the question if you don't know what money actually is. Proposing to eliminate it entirely seems utopian and naive.

My life used to be like that game of freeze tag we played as kids. Once tagged, you had to freeze in the position you were in. Whenever something happened, I'd freeze like a statue, too afraid of moving the wrong way, of making the wrong decision. The problem is, if you stand still too long, that's your decision.

Your problem is how you are going to spend this one odd and precious life you have been issued. Whether you're going to spend it trying to look good and creating the illusion that you have power over people and circumstances, or whether you are going to taste it, enjoy it and find out the truth about who you are.

Confronted with this double madness of the labourers killing themselves with over-production and vegetating in abstinence, the great problem of capitalist production is no longer to find producers and to multiply their powers but to discover consumers, to excite their appetites and create in them fictitious needs.

I've had this terrible stomach problem for years, and that has made touring difficult. People would see me sitting in the corner by myself looking sick and gloomy. The reason is that I was trying to fight against the stomach pain, trying to hold my food down. People looked me and assumed I was some kind of addict.

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