The premise of 'Descent' may sound pretty straightforward: One summer morning while vacationing with her family in the foothills of the Rockies, a young girl, a high-school athlete in her senior year, goes out for a run in the higher altitudes - and disappears.

I am still bowled over by this great young adult novel by David Levithan called 'Every Day,' which is about a character with no gender or body who wakes up every day in the body of a different person. It's a really impressive execution of a really great premise.

Every time you get on a stage or in front of a camera, the whole exercise is about imagination. You're constantly depicting something that doesn't exist, and trying to find the reality of it. Once you settle on that premise, everything else is a matter of degrees.

Nobody just flops a complete 'Doc Martin' script on the desk. They all have to be taken apart and all the apologizing taken out. Because it's hard to have a protagonist that doesn't really like anyone and nobody really likes him; it's a hard premise to start from.

A fundamental premise in cancer therapy is trying to identify how the metabolism of cancer cells differs from normal tissue. When differences are identified, it often paves the way for treatments that will disrupt the cancer's metabolism while sparing normal tissue.

The 'Dog's Purpose' premise has gotten me so many emails and comments from people who say that their dog is so much like one they had when they were young or years before, that it seems like the truth. The idea that you would come across an old friend later in life.

If we start - premise that the information is mine, and we give the individual's rights, we worry about what happens during a breach. If you try to protect access to it, as opposed to not even making it available, you have less to worry about who will break the wall.

Tonight, we gather to affirm the greatness of our nation - not because of the height of our skyscrapers, or the power of our military, or the size of our economy. Our pride is based on a very simple premise, summed up in a declaration made over two hundred years ago.

Conspiracy theorists of the world, believers in the hidden hands of the Rothschilds and the Masons and the Illuminati, we skeptics owe you an apology. You were right. The players may be a little different, but your basic premise is correct: The world is a rigged game.

My own field of paleontology has strongly challenged the Darwinian premise that life's major transformations can be explained by adding up, through the immensity of geological time, the successive tiny changes produced generation after generation by natural selection.

Believe it or not, I write on stage. I can't write anywhere else; I have to be in a moment. I also have to challenge myself to make something funny out of a premise. I never have my own jokes written. I have to change things as I go along, and I have to entertain myself.

With the premise that we look for technical co-founders to run a company, I view myself as being a coach to that technical co-founder. I can help them with their business issues, with the growth issues of taking a company from a very early stage to something much larger.

My premise is that there's something hardwired into our DNA, that we as a species came and evolved from caves and clans and tribes, and therefore, we as a species care more about the things that are local to us than we care about the things that are 'over there' from us.

To be honest, the first time round, I didn't think 'Fame Academy' was the worst premise in the world. You got people on, and they would write songs and develop themselves as artists. But then, instead of getting a little bit more credible, it got a little bit more ridiculous.

For years I've wanted to write a book about mummies, and had been following the science of mummy CT scans when the premise for 'The Keepsake' occurred to me: what if an 'ancient' mummy turns out to have a bullet in its leg? How does a modern murder victim get turned into a mummy?

The liberals think government exists to fix what's wrong with America. They find fault with our Constitution, our economic model and our core values. We disagree with the premise of their argument. We believe there's nothing wrong with America that an extra dose of freedom won't cure.

I'm always interested in the ways in which a character can inhabit either a theme or a premise personally, so that those scenes that are about his character or his relationship with other characters feel in context and don't seem to be apart from or oddly vestigial to the actual drama.

The premise of Nossiter in 'Mondovino' would have been a lot more accurate when I started writing about wine in 1978 than when the movie was made in 2003. When I started, I was enormously critical of California wines, and I thought the entire wine industry was on a real slippery slope.

I offer something very different from the lifelong career politicians who have worked their way up to run for higher office or those who can parachute in with checks for $5 million or $10 million, and that seems to be the definition of credible or legitimate. I'm rejecting that premise.

No two dramatists think or write alike. Ten thousand playwrights can take the same premise, as they have done since Shakespeare, and not one play will resemble the other except in the premise. Your knowledge, your understanding of human nature, and your imagination will take care of that.

The premise of my whole campaign has been not that people need to believe what I say to them, but they need to look at what I have done. And what I have done in the state of Nevada, I have voted over a 100 times against tax and fee increases, poor public policy, and unconstitutional bills.

I would be excited if we could reimagine workplaces that start from a premise that women are going to be a central part: Women are going to bear children, people are going to raise those children, and it's not going to be a nuisance - it's actually going to be understood as part of the deal.

I was on a show called 'SliDE' when I graduated from college, and then that set the premise of my love for acting. It was so much fun. I was on set with my best friends every day. From that, I got 'Home and Away' and it was such a relaxed, friendly environment. Everyone's so kind and supportive.

What they told us about 'Star Trek: The Next Generation' when we first started was that we were guaranteed 26 episodes, so that was the longest job I've ever had. And that was basically it - we didn't know what the premise of the show was going to be and we waited, week by week, to see a script.

My whole premise has been, right from the beginning, that it would take me a lifetime to learn to explain myself as an artist. As you grow older, you learn what to do and what to leave out. You kind of simplify your work and get the same thing done with fewer strokes. It's pretty interesting to me.

No, you don't have to start your play with a premise. You can start with a character or an incident, or even a simple thought. This thought or incident grows, and the story slowly unfolds itself. You have time to find your premise in the mass of your material later. The important thing is to find it.

'The Last Patriot' is set in the present day but is based upon the premise that the Prophet Mohammed had a final revelation, he shared it with his disciples, and they killed him to keep it hidden and out of the Qur'an. If this missing revelation can be found, its impact on the world will be incredible.

I had an insanely long commute - New York to D.C. - when I worked at 'National Geographic.' I hate to waste time, so I spent my time by writing about my life on the premise that I might be able to pitch those as short essays to magazines. It wasn't until later that I realized that I was writing a book.

I realized, year of the tiger was 1974, which was the year my father passed away when I was a kid... My family, at that point, were Christian Scientists. So basically, this woman Mary Baker Eddy started this in the 1800s, and the premise is that you don't go to doctors. You believe that God is gonna heal you.

The Lean Startup is a process for turning ideas into commercial ventures. Its premise is that startups begin with a series of untested hypotheses. They succeed by getting out of the building, testing those hypotheses and learning by iterating and refining minimal viable products in front of potential customers.

As I had visualized, 'Heroine' is shaping up to be a very contemporary film with a different premise and strata. This film, like most of my other films, is a blend of facts and fiction. The film has a larger span, more characters, and costumes... a journey that revolves around an actress's life and the showbiz.

The well-known inspiration for 'Ulysses' is made clear by the title itself: Joyce's novel is based on Homer's 'Odyssey', under the ever-fascinating premise that all of Odysseus' extraordinary adventures can be experienced by a modern man in a single day, provided that the writing consists of his mental activity.

The diminishment of southern contests is the kind of veiled racist rhetoric that Bill Clinton deployed memorably in South Carolina in 2008, and which does not look any more attractive on Bernie - the guy whose campaign is centered on the premise that he plays cleaner and more progressive politics than his opponents.

The administration must act promptly to ensure that the central premise of the Affordable Care Act is executable and, rather than dismissing criticism, should examine it in good faith and work to serve the needs of the people. President Obama must approach this problem like a CEO confronting a very bad product launch.

The premise of insurance is to spread the risk. It's the premise of homeowner's insurance, of car insurance, and of health insurance. It's one reason why it's important to have insurance when you're healthy, so that when you get sick, you won't go sign up just when you get sick, because that increases the cost for everyone.

First of all, you ask me if the God of Christians forgives one who doesn't believe and doesn't seek the faith. Premise that - and it's the fundamental thing - the mercy of God has no limits if one turns to him with a sincere and contrite heart; the question for one who doesn't believe in God lies in obeying one's conscience.

'Dating Game' wasn't social commentary, political analysis, Shakespearean-level drama or even blunt-force comedy. It was just the televised equivalent of meeting someone at a bar. But it appealed to our most basic Darwinian instinct: selecting a good mate. You can't go wrong when a show's premise is hard-wired into human DNA.

As a culture, we've all agreed with the opinion that the world should be seen in a certain way, so at 'The Nightly Show,' our chief mission was to disagree with that premise. And to see the world in a way that may not make everybody comfortable. And to present it with a cast of people who don't always get to have a voice on that.

I have written a new book called 'The Golden Motorcycle Gang.' The premise of the book is taken from actual events in my life. My life has been dedicated to inspiring and motivating others to live their highest vision of their ideal life and offering transformational trainings that help people succeed in all aspects of their lives.

There are philosophical issues involved in that about choosing the right discount rate, the value, the future, and things like that which drive it. But its start with the premise that global warming is real and if you're a denier of that fact, then you're not going to find climate change mitigation policies to have particular appeal.

I know that there is a near unanimous view in Congress that state or local taxes on Internet access would directly deter the ability of consumers to obtain and utilize the Internet. If that is an accepted premise, as it should be, the same concept should apply to the net neutrality debate and its certainty to increase consumer bills.

I totally disagree with the premise that al Qaeda is on the path to defeat. Quite the contrary, al Qaeda has deliberately decentralized its operations - not because of the relentless attacks we have had on its national leadership in Pakistan, but because its strategic objective is to dominate and control Muslim countries in the region.

In general, the straight line of a joke sets up a premise, an expectation. Then the funny ending - the punch line - in a sense contradicts the original assumption by refusing to follow what had seemed a reasonable train of thought. Many jokes involve that simple matter of leaping outside what had appeared to be the rules of the game at the moment.

Democracy's premise rests on the notion that the collective wisdom of the majority will prove right more often than it's wrong; that given sufficient opportunity in the pursuit of happiness, your population will develop its talents, its intellect, its better judgment; that over time its capacity for discernment and self-correction will be enlarged.

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