Quotes of All Topics . Occasions . Authors
Having the BRCA mutation significantly increases the risk of breast cancer, but it is not always the only factor. Lifestyle choices may increase or decrease the risk of breast cancer, but that knowledge is an opportunity to empower ourselves, not to blame.
The problem with Ebola is that it makes mistakes while it copies itself. The mistakes are actually good for Ebola because they help Ebola change, and as a result of this, as it jumps from one human body to the next, roughly half the time, it's got a mutation.
In Darwin's theory, you just have to substitute 'mutations' for his 'slight accidental variations' (just as quantum theory substitutes 'quantum jump' for 'continuous transfer of energy'). In all other respects little change was necessary in Darwin's theory...
I know that the human condition will be radically changed through technical means. Much of this change will be painful, monstrous and horrible. Most mutations are disgusting failures, most experiments are failures. I accept this and I don't find it frightening.
Because of the vulgar advent, I decided to give way and, by dark and cryptic sentences, tell of the causes of the future mutation of mankind; especially the most urgent ones, and the ones I perceived, and in a manner that would not upset their fragile sentiments.
That the primary effect of gene mutation may be as simple as the substitution of a single amino acid by another and may lead to profound secondary changes in protein structure and properties has recently been strongly indicated by the work of Ingram on hemoglobin.
Attempts have been made from a study of the changes produced by mutation to obtain the relative order of the bases within various triplets, but my own view is that these are premature until there is more extensive and more reliable data on the composition of the triplets.
Sickness is the natural state in which we humans reside. We occasionally fall into brief brackets of health, only to return to our fevers, our infections, our rapid, minute mutations, which take us toward death even as they evolve us, as a species, into some ill-defined future.
We have seen that in certain respects operant reinforcement resembles the natural selection of evolutionary theory. Just as genetic characteristics which arise as mutations are selected or discarded by their consequences, so novel forms of behavior are selected or discarded through reinforcement.
On the morning of May 1, 2018, I woke up knowing that the day I had anticipated for nine years had finally arrived. It was the day of my preventative double mastectomy - the day I would attack my BRCA 2 genetic mutation head-on and take my chances of breast cancer from 84 percent to virtually zero.
Bacteria evolve, and so they become resistant to existing drugs. Sometimes they revert, depending on how damaging the mutation is to the life cycle of the bacteria. Mutations that give rise to resistance against particular compounds do increase, and that is why you constantly have to have new ones.
A mutation can create an alternative form of a phenomenon - a phenotype or trait - and we can learn a lot by seeing this alternative state. Once I saw a mouse with no eyelids. It simply had a membrane over the eyes. I found it fascinating that there is a single gene required for eyelids to develop.
It may act as an ancillary factor, but by itself, the mutation in tau doesn't give you Alzheimer's disease. This is not to say the tau is not very important. It may be important in propagating the disorder from one cell to another. But as a causal mechanism, the evidence is strongest for beta amyloid abnormalities.
The evolution of cultures appears to follow the pattern of the evolution of species. The many different forms of culture which arise correspond to the "mutations" of genetic theory. Some forms prove to be effective under prevailing circumstances and others not, and the perpetuation of the culture is determined accordingly.
In the abstract, it might be tempting to imagine that irreducible complexity simply requires multiple simultaneous mutations - that evolution might be far chancier than we thought, but still possible. Such an appeal to brute luck can never be refuted... Luck is metaphysical speculation; scientific explanations invoke causes.
Every mutation through a new combination of genetic factors that provides the organism with a new opportunity for coming to terms with the conditions of its environment signifies no more and no less than that new information about this environment has got into that organic system. Adaptation is essentially a cognitive process.
Science fiction [is] the kind of writing that prepares us for the necessary mutations brought about in society from an ever changing technological world and as a result. The mainstream hasn’t excluded SF; the mainstream has excluded itself. No one told Jules Verne he was a science fiction writer, but he invented the 20th century.
There is some research that suggests that viruses like the flu are really actually kind of at the razor's edge when it comes to mutation. They're mutating so fast that if they mutated much faster they would actually develop a lot of harmful mutations that could slow them down and cripple them and eventually literally drive them extinct.
Yoga is existential, experiential, experimental. No belief is required, no faith is needed - only courage to experience. And that's what's lacking. You can believe easily because in belief you are not going to be transformed. Belief is something added to you, something superficial. Your being is not changed; you are not passing through some mutation.
Our lives are about development, mutation and the possibility of change; that is almost a definition of what life is: change... If you disable change, if you effectively stop time, if you prevent the possibility of the alteration of an individual's circumstances — and that must include at least the possibility that they alter for the worse — then you don't have life after death; you just have death.
The tragedy of a species becoming unfit for life by over-evolving one ability is not confined to humankind. Thus it is thought, for instance, that certain deer in paleontological times succumbed as they acquired overly-heavy horns. The mutations must be considered blind, they work, are thrown forth, without any contact of interest with their environment. In depressive states, the mind may be seen in the image of such an antler, in all its fantastic splendour pinning its bearer to the ground.
