I think part of what makes someone a great actor is being able to walk into a situation emotionally available and open, and have all your guards down, and just have that level of trust and security in yourself to know that you could walk out on that limb with someone else and be safe.

Leh has few of what Europeans regard as travelling necessaries. The brick tea which I purchased from a Lhassa trader was disgusting. I afterwards understood that blood is used in making up the blocks. The flour was gritty, and a leg of mutton turned out to be a limb of a goat of much experience.

I certainly know what it is like to go to work and leave your baby at home. It is an ache that only other mothers can understand. I always say that it feels like you've left a limb at home. And I really struggled for the first few months of work. There were times when I shut myself in my room and cried.

Any time you're stepping out on a limb as an artist, it's scary, especially when you have a lot of success. When you're reaching a lot of people, the masses, it's easy to stay in that niche, you know? Especially when you're making a lot of money and you know there's a formula, it's easy to stay in that rut.

Reading 'Youth in Revolt' might have ruined my career because suddenly I wanted to abandon all the emotional truth of something and just go out far on a literary limb with completely implausible things that relied completely on voice and humor. And what saved me is realizing that I couldn't do that very well.

As a producer, sitting on the other side of the desk, I have never once had an agent go out on a limb for his client and fight for him. I've never heard one say, 'No, just a minute! This is the actor you should use.' They will always say, 'You don't like him? I've got somebody else.' They're totally spineless.

They're making so few movies that you really just have to make it. It's going to be the only way you end up getting work. I don't believe anyone's going to really go out on a limb and just throw millions of dollars on someone that's not been proven. They're going to have to show somebody something at some point.

There's a broad range of male rappers, so if they're going out on a limb and they sound different, it's okay, because we have 20 other rappers doing what the radio wants... as far as females, there aren't as many, so if you want to compete, you have to sound just like this, because that's the only thing hot right now.

I've had lots of fans who come out and say, 'Listen, I can relate to Cyborg because I lost a limb,' or 'I have this cochlear implant.' It's one of those things when you actually start seeing it, when you actually start hearing about it, that made Cyborg more relevant to me than I think he ever had been up until that point.

Every one says: 'Listen, I'd love to reinvest. I'd love to hire people. But I have no idea what this healthcare bill is going to do to my bottom line. I have no idea what this financial reform bill is going to do... I'm not going to step out a limb and do any of those until I know what this government is going to do to me.'

The older I get, for me it's about fear. If I read something and it scares the hell out of me, that's what I want to do. If it's a challenge and a massive risk and I'm going out on a limb ... those are the ones I want. And they are few and far between. I don't work very much because I'm very specific about what I want to do.

So here is one of my theories on happiness: we cannot know if we have lived a truly happy life until the very end. This view of life and death was reinforced by my close witnessing of the buildup to the death of Philip Gould. Philip was without doubt my closest friend in politics. When he died, I felt like I had lost a limb.

The painter who is familiar with the nature of the sinews, muscles, and tendons, will know very well, in giving movement to a limb, how many and which sinews cause it; and which muscle, by swelling, causes the contraction of that sinew; and which sinews, expanded into the thinnest cartilage, surround and support the said muscle.

Science has a culture that is inherently cautious and that is normally not a bad thing. You could even say conservative, because of the peer review process and because the scientific method prizes uncertainty and penalises anyone who goes out on any sort of a limb that is not held in place by abundant and well-documented evidence.

Anyone working in the media can tell you that there seems to be an always-ready-to-explode segment of the populace for whom offense is a fate worse than anything imaginable. You'd think offense is one of the most calamitous things that could happen to a human being; right up there with the loss of a limb, or just missing a parking space.

I think pain is a very - it's an extremely hard thing to empathize moment to moment. And you often don't remember your own pain, you know, that moment that you broke a limb or you burned yourself or, I think, this is a common thing that women talk about with childbirth, that the memory of the pain is hard to summon up and relive, thankfully.

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