Bitcoin is absolutely the Wild West of finance, and thank goodness. It represents a whole legion of adventurers and entrepreneurs, of risk takers, inventors, and problem solvers. It is the frontier. Huge amounts of wealth will be created and destroyed as this new landscape is mapped out.

The dependencies of inner and outer Mongolia are the bulwarks of China. The desert of Gobi, stretching for ten thousand li, is a barrier set by Heaven to the Russians, and if they seek to invade our borders, they will find it everywhere along the Northern frontier difficult and troublesome.

We go as humans into space to expand the domain of humanity and life - not robots. And as we do, we will get more science because when you are living somewhere, you obviously learn more about it. NASA and the government must first get out of the way and then support us as we open the frontier.

Autoimmunity is probably the next frontier. The majority of cases of autoimmune disease result from a complex genetic problem that has environmental influences. It is a colossal task for the immune system to maintain tolerance to self and yet be ready to react to everything in the world around us.

When a very tough, old school leader announced that I was his pick to be Chief of Station in a small but important frontier post, a few competitors complained to me directly 'why would they send you?' I owe that leader much for believing in me at a time when few women were given these opportunities.

I was born on the 24th of September 1755 in the county of Fauquier, at that time one of the frontier counties of Virginia. My father possessed scarcely any fortune and had received a very limited education - but was a man to whom nature had been bountiful, and who had assiduously improved her gifts.

For a few thousand years, women had no history. Marriage was our calling, and meekness our virtue. Over the last century, in stuttering succession, we have gained a voice, a vote, a room, a playing field of our own. Decorously or defiantly, we now approach what surely qualifies as the final frontier.

One thing I've always loved about the culture at Microsoft is there is nobody who is tougher on us, in terms of what we need to learn and do better, than the people in the company itself. You can walk down these halls, and they'll tell you, 'We need to do usability better, push this or that frontier.'

The amazing thing about the sea is that it is perhaps the last truly unexplored frontier; most oceanographers estimate that only about ninety-five per cent of the sea has been studied. Meanwhile, the oceans are believed to contain more animals than exist on land, a majority of which have never been discovered.

If you're going to lead a space frontier, it has to be government; it'll never be private enterprise. Because the space frontier is dangerous, and it's expensive, and it has unquantified risks. And under those conditions, you cannot establish a capital-market evaluation of that enterprise. You can't get investors.

Life in cyberspace is often conducted in primitive frontier conditions, but it is a life which, at its best, is more egalitarian than elitist and more decentralized than hierarchical. It serves individuals and communities, not mass audiences, and it is extraordinarily multi-faceted in the purposes to which it is put.

Did you come of age in those sweet summers of the early nineteen-sixties, when the airwaves were full of rock and roll's doo-wop promise of joy and the nation was full of J.F.K.'s eloquent promise of a New Frontier? I did. Life seemed to be laid out before us like a banquet; everything was for the taking, especially hearts.

As always, space remains an unforgiving frontier, and the skies overhead will surely present obstacles and setbacks that must be overcome. But hard challenges demand fresh approaches, and I'm optimistic that Stratolaunch will yield transformative benefits - not only for scientists and space entrepreneurs, but for all of us.

We're in this amazing frontier of transparency. WikiLeaks. Edward Snowden. 'Westworld' is reflecting that with these robots gaining consciousness. Them coming into consciousness is almost like us, human beings, coming into the truth of the fact that government is corrupt. Police are corrupt. Banks are corrupt. Etcetera, etcetera.

Americans' distrust of the conspicuously intellectual - a habit we learned, I suppose, on the frontier, but which remains a feature of the national character - has the virtue of puncturing the pretentious and exposing the fake, but it may also have impaired American listeners' patience for music that is especially complex or austere.

So the history of discovery, particularly cosmic discovery, but discovery in general, scientific discovery, is one where at any given moment, there's a frontier. And there tends to be an urge for people, especially religious people, to assert that across that boundary, into the unknown, lies the handiwork of God. This shows up a lot.

Abraham Lincoln comes from nothing, has no education, no money, lives in the middle of nowhere on the frontier. And despite the fact that he suffers one tragedy and one setback after another, through sheer force of will, he becomes something extraordinary: not only the president but the person who almost single-handedly united the country.

When someone died in the wilderness of frontier America, that person's physical remains were buried and the handcarts continued west, but the mourning survivors had hope for their loved one's eternal soul. However, when someone dies spiritually in the wilderness of sin, hope may be replaced by dread and fear for the loved one's eternal welfare.

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