The 1890s was a decade when life began to change in urban America. Modern conveniences that we now take for granted came into use; women's roles became less restrictive; and San Francisco, a port city with influences from all over the world, was a lively place in which to reside.

The cool parts - the parts that have won Dubai its reputation as 'the Vegas of the Middle East' or 'the Venice of the Middle East' or 'the Disney World of the Middle East, if Disney World were the size of San Francisco and out in a desert' - have been built in the last ten years.

It's weird, when I go back to San Francisco, the few times that I've done shows there since leaving, it still feels like I live there. It's very, very strange for me. That's where my daughter was born, at UCSF. I have this huge attachment to San Francisco. It's like a love affair.

The status quo tough-on-crime policies of the '90s and 2000s are not working and are not popular. And it provides me with hope about the possibilities for San Francisco and this whole country in terms of moving away from our dependence on prisons and jails to solve social problems.

My very first role was with James Earl Jones on 'Gabriel's Fire' on TV. He drove a Chevy Citation, which is the exact same car that I bought from a guy in San Francisco called Sandy Boone. I showed up on set, and James Earl Jones was driving the car I had bought from Sandy for $250.

When I was a kid, I really wanted to be a writer and an artist when I grew up. So in college, I was an English major, and then I became a fine artist. But when I arrived in San Francisco in 1995, I figured I could leverage my artistic skills by becoming a Web designer and programmer.

When we first started Glitch, there were four co-founders of the company. We built Flickr and worked together at Yahoo and then started Tiny Speck. We were split in Vancouver, New York, and San Francisco. So we used an old chat technology called IRC. Almost nothing went through email.

One hot summer night in San Francisco, roughly 10 years ago, I was sitting in a crowded Pacific Heights restaurant when Alice Adams walked in with a man. She was about 60 at the time, and she was wearing a skirt that fell an inch or so above her knees and flat heels without stockings.

I think Hitchcock had a thing about hills: think of the house on the hill in 'Psycho.' Then, in 'Vertigo,' Scottie is forever traversing the city, going downhill all the time as he goes deeper and deeper into himself. It's as if Hitchcock is using San Francisco as a psychological map.

In the 1960s, as a rising defense intellectual, Kissinger was a Nelson Rockefeller man, firmly entrenched in the center-right establishment. When he attended the infamous 1964 Republican convention in San Francisco, he was horrified by Goldwater supporters, whom he likened to fascists.

I had a terrible motorcycle accident, in San Francisco as matter of fact. Doing a picture called... oh, this is terrible. It's a very well-known film and I can't remember the name. That's what happens when you get older... I fell off a bridge in San Francisco and was laid up for two years.

There are old people in San Francisco because my parents still live there. The young tech bros don't see old people or children. The Mission district, where they live and work, they don't see children or old people. That statement revealed, to me, the blinders that the techies are wearing.

Now Dave Eggers, if you lived in San Francisco, is not an easy person to be done with. Everyone - and by everyone, I mean every white person with a college education and an interest in books - wants a piece of him. It's not just his amazingly powerful prose; it's also his charitable works.

When I first played '1234' it was on stage in San Francisco at some kind of, like, sticky-floored club. And it felt like a punk song. I mean it's ridiculous to say that now, but it had that kind of, like, piercing straight melody. And then this fist-pumping ending, you know that pa-dap-pada.

When I left the San Francisco DA's office, I went down to the Los Angeles district attorney's office, and I was able to try a tremendous amount - very serious cases and working in gang neighborhoods, impoverished neighborhoods - really make a difference and be impactful in those communities.

In San Francisco, I am proud to say that one of my first mandates as district attorney was that my staff would never ask the court to impose money bail. If we believe someone is too dangerous to be released, then it doesn't matter how wealthy they are - we should ask the court to detain them.

When I got a chance, I went back and shared those experiences that were important to me. George Washington High, the campus at San Francisco State, and even back to Emerson Elementary school and Roosevelt Junior High. I was happy to do it, to go back and see if all the same teachers were there.

I think I have femininity, I have masculinity, but I get to use all of Jeffrey, and that's very powerful. And this is what I always thought when I went down in my little basement in San Francisco, where I grew up, and daydreamed about being an actor: It felt like this. This is what it felt like.

In 2004, I was visiting my cousins in San Francisco and we were in a restaurant talking in Punjabi. We suddenly saw heads turn. And one of the Americans at the restaurant abused us and called my cousins, 'turban-headed Osamas.' That strengthened my resolve to make a film that highlights the issue.

Whether an economic boom is fueled by the fashion industry or technology innovations, it needs a brick-and-mortar foundation. This is not only true in New York and San Francisco; wherever you live, you can find a local hotspot positioned to attract interest from businesses, consumers and investors.

When my dad retired, he moved to Georgia, but I stayed in California. I was in San Francisco: that's where I first went from being a musician to making beats and producing. I was 18, 19. It started going pretty good for me out there in California, so I stayed in SF while my parents moved to Georgia.

A lot of the people in Northern California and parts of Oregon have decided that we are not on the same page as San Francisco and Portland and Los Angeles. I don't know if six states is a solution because is Washington, D.C. and the rest of the country really going to give California 10 new senators?

I went to college and did theatre. After that, I spent about three years in Seattle doing French theater and community theater and sorting it all out. Then I applied to graduate school and got accepted, so I started pursuing my master's in theatre at the American Conservatory Theatre in San Francisco.

When I came to University of California, San Francisco to work on infectious disease, I looked around to different options, and malaria was particularly interesting and fascinating to me. It's amazing that after 100 years of study of this little parasite, we've not been able to effectively control it.

I wanted to be a classical actress. I plodded along. I went to junior college in San Francisco, I was in a Repertory Company. My hero was Eva Le Gallienne, who was a great theater actress at the turn of the century who created her own company, and she wrote these hilarious autobiographies at the time.

I was inspired to see leaders from Paris, New York City, San Francisco and Vancouver, B.C. rolling up their sleeves to create clean and safe transportation systems; make homes and buildings efficient, comfortable and affordable; and ensure more of our energy comes from clean sources like wind and solar.

When you work with web design companies in San Francisco, you end up with a bunch of twenty-somethings who have their own cultural peculiarities, including obscurity for its own sake. You give those guys a website for a banking institution and they screw it up, because they are designing for themselves.

I grew up in Little Rock, Arkansas, and before the Internet and before everything, just to get anything interesting, you had to go on vacation to San Francisco or something. But I think when you're in the middle of America, you feel very jealous of not just comedy but music that you don't have access to.

Before I got into grad school, I used to work as a deck hand on these ferry boats in San Francisco, and they did day tours. It wasn't a bad job. I made decent money. But you were sitting down all day, tying up the boat, wiping it down. For some guys, that's a dream job, but for me it was kind of torture.

A city is where you can sign a petition, boo the chief justice, fish off a pier, gaze at a hippopotamus, buy a flower at the corner, or get a good hamburger or a bad girl at 4 A.M. A city is where sirens make white streaks of sound in the sky and foghorns speak in dark grays. San Francisco is such a city.

Whether it's Al Michaels, when the earthquake happened in San Francisco and his ability to handle it like Walter Cronkite would have handled it, or Bob Costas with his overview of what's happening with worldly events at the Olympics and the perspective that he has there, you know these guys are so well read.

I go up to San Francisco on holidays and spend time with my family there, but whenever I go to Japan, I enjoy every moment. I try to go back there every year or so. It's a phenomenal place, and I absolutely love it. It's not my second home; it is my home. Whenever I go back, I feel very connected with Japan.

One winter, I went to Erfoud to research trilobites and got to know the quarries, the dealers, and the remote mining villages. They are not easy places to visit, and this was a completely unknown corner of the world economy: children slaving away on desert cliffs to furnish wealthy collectors in San Francisco.

I remembered staffing a volunteer table for ACT UP in San Francisco's Castro neighborhood in 1991, on the corner of Castro and 18th Street, and on my table were posters, stickers, and t-shirts that bore the same slogan in all caps - ACT UP slogan house style. I wore one of those shirts to model for passers-by.

In the summer of 2009, in the wake of a crisis in her life, my mother moved from San Diego to San Francisco to live with my 16-year-old daughter and me. My mother was 77. I was 51. Despite a chorus of skepticism from friends - who knew about my upbringing - I was determined to do what I could to help my mother.

I had talked for years about doing a restaurant with Rocky Dudum, who's been my friend since I first came to San Francisco. Then Rocky's son, Jeff, said he wanted to design it, so he traveled around the country to sports restaurants like Mickey Mantle's and Michael Jordan's, and he came up with a great concept.

One of the nice things about the United States is that, wherever you go, people speak the same language. So native New Yorkers can move to San Francisco, Houston, or Milwaukee and still understand and be understood by everyone they meet. Right? Well, not exactly. Or, as a native New Yorker might put it, 'Wrong!'

In San Francisco, I found Warren Levinson, who had set up a program to study Rous Sarcoma Virus, an archetype for what we now call retroviruses. At the time, the replication of retroviruses was one of the great puzzles of animal virology. Levinson, Levintow and I joined forces in the hope of solving that puzzle.

In the late 1960s, Ontario Airport was a throwback to a bygone era. Located 35 miles east of downtown Los Angeles, the airport served only two carriers, Western and Bonanza. Passengers could catch regional flights to San Francisco, Sacramento, Las Vegas, Palm Springs, Phoenix and Los Angeles, and that was about it.

I used to be a pretty hard-core iPhone fan. But over time, I grew more and more frustrated with the lousy service on AT&T. My iPhone simply could not reliably make and hold a phone call. Not just in New York and San Francisco, where I spend a lot of time, and where AT&T's service has been notoriously bad for years.

Moving to San Francisco affected me in a pretty profound way, in a lot of respects. I think it helped me evolve my sound and think outside of the space I'd been in in Sacramento. The scene there is so insular and kind of feeds on itself: you just end up playing the same shows with the same people for the same people.

After college, I went to San Francisco and worked as a secretary in a reinsurance company. That was a pretty dismal job. It was a real small place. Guys would come in, and they'd sort of stick out their arms like wings so I could take their coats off. They'd tell me, 'Two,' and I'd put two lumps of sugar in their coffee.

I've got one of those over-stuffed leather chairs from the Pottery Barn. It faces north. I live in San Francisco, so there's the Golden Gate Bridge off to the left, and there's Alcatraz off to the right, and I've got a pile of pulp fiction next to me, and there's usually a decent bottle of red wine next to the fireplace.

We opened the first Men's Wearhouse in Houston in August 1973, then a store a year for 10 years in Texas. In the early 1980s I opened a store in the San Francisco Bay Area. Within the year, the Texas economy was in total disarray. We were facing Chapter 11, and if not for the California store, we might not have survived.

I know it's a cliche, but I see myself as a citizen of the world. I was brought up in Switzerland by German and Turkish parents but I've very much grown up in San Francisco. I have a European sense of aesthetic, but I'm also deeply steeped in the notion of change and entrepreneurship that is associated with Silicon Valley.

I went on a book tour immediately after 9/11. I was due to leave the following Wednesday, so I just did. It was an amazing thing, because planes hadn't been flying very many days, and I got on this plane and went to San Francisco, and the minute that plane lifted above the clouds, I felt this incredible sense of lightness.

I would stay two years in San Francisco, then move to New York in the summer of 1991, for the love of a man who lived there. When I arrived in New York, I had a job waiting for me, courtesy of a bookstore I'd worked at in San Francisco, A Different Light. They had a New York store as well, and arranged an employee transfer.

As a child growing up in San Francisco in the 1950s, I sometimes met insults when I ventured outside of Chinatown or my neighborhood. I have even been spat on and threatened with a knife. I could have let my anger fester until it became hate. However, I realized they were isolated incidents, and I simply got on with my life.

Performing comedy in San Francisco to begin with is pretty wild. You've got to - you've got the human game preserve to play off of. And it's a lot of great characters everywhere. You work off that, and then you play the rooms, and eventually you get to a point where you're playing a club that is a comedy club, with other comics.

Portland doesn't have a 'sit-lie' ordinance like Seattle or San Francisco. Our use of high pedestrian zones is significantly more limited and nuanced, but it gives authorities the flexibility they need to address specific public safety or public health threats in congested areas, by keeping our sidewalks accessible and walkable.

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