Most Fortune 500 companies began as small start-ups whose entrepreneurial founders slowly developed the infrastructure, hired the staff, sourced manufacturers or built their own factory, and created distribution, sales, and marketing plans.

There are lots of people building the next TransferWise, not in a sense of competing with us but in a sense of building large, successful companies that are doing something important. I just enjoy helping these founders navigate the journey.

The period 1924 to 1929 was spent studying chemistry at the Czech Institute of Technology in Prague, Czechoslovakia. The supervisor of my thesis was Professor Emil Votocek, one of the prominent founders of chemical research in Czechoslovakia.

Usually, the first three months post acquisition are up and down. The acquirer and the acquiree are trying to figure out how to interact. The founders of the acquiree are usually tired from the deal process and adjusting to their new reality.

Big-government proponents embrace both the power of the federal government and the idea that millions of Americans ought to be dependent on its largesse. It's time to return to our Founders' love for small government. More is not always better.

America's founders were clear that the Constitution established a federal government of few and defined powers. It cannot regulate any activity it chooses, but they only regulate in those areas which the Constitution grants it power to regulate.

Americans are right to wonder if, at long last, what George Washington called the Great Experiment has failed, and that our founders have lost their extraordinary wager that regular people could govern themselves better than a few rich men could.

I'm still one who says that we can get rid of the Internal Revenue Service if we would pass the fair tax, which is a tax on consumption rather than a tax on people's income, and move power back where the founders believed it should have been all along.

There are not enough female VCs in an industry so traditionally dominated by males. There are not enough female mentors who are actively engaged with female founders. We need women VCs and entrepreneurs to stand up, get loud, and help guide their peers.

For resourceful tech founders, finding capital is rarely a problem; making the best use of it is another story. A few years slinging pepperoni pies and chicken wings - on tiny margins and with minimal investment - might not be the worst fiscal training.

One of the things that is so important, critical I think, in reading not just the founders but thousands of years as you put it, that discussion about corruption, is that you can't talk about the problem of corruption without talking about human nature.

In the new artisan coffee movement, Jeremy Challender, a 32-year-old Australian who is one of the founders of Prufrock Coffee, explains precision is everything for the barista. Jeremy is able to analyse his coffee with the benefit of an app on his phone.

Founders have continually struggled with and adapted the 'big business' tools, rules, and processes taught in business schools when startups failed to execute 'the plan,' never admitting to the entrepreneurs that no startup executes to its business plan.

The classic problem as an entrepreneur is that they have a hard time delegating. But that's really crazy. Recruiting other executives is critical, so is dealing with customers and dealing with regulators. Those are functions that only the top founders can do.

As a member of Congress, a coequal branch of government designed by our founders to provide checks and balances on the executive branch, I believe that lawmakers must fulfill our oversight duty as well as keep the American people informed of the current danger.

Founding a company is hard. Most of it isn't smooth. You'll have to make very hard decisions. You have to fire a few people. Therefore, if you don't believe in your mission, giving up is easy. The majority of founders give up. But the best founders don't give up.

The next generation of innovators, who need neutrality the most, are not at the bargaining table. They're hard at work in their labs or classrooms, dreaming of the next big thing, and hoping that the Internet is as open to them as it was to the founders of Google.

'E pluribus unum' is perhaps the most obnoxious motto the Founders could have come up with, as far as liberals are concerned. They don't mind the e pluribus part - they love to note the things that divide and separate us. But they positively despise the unum part.

The best tech companies are led by founders with entrepreneurial zeal and strong egos. They consistently deliver what we want and what we need, at prices that decrease over time. The Wall Street firm is a long-standing institution with a more established hierarchy.

I find talented, driven, boundlessly ambitious people and help them solve problems that will hopefully improve the lives of millions. Sometimes this means investing in startup founders. Other times, it involves helping organize and fundraise for charity or politics.

The justification for early boarding is based on a massive but common misconception. Because physical hardship in childhood makes you physically tough, the founders of the system believed that emotional hardship must make you emotionally tough. It does the opposite.

Too often, founders make decisions before determining whether they are the right thing to do. These decisions often create chaos in their companies where people are having to jump from the last 'great idea' to yet another unproven-and-about-to-be-poorly-executed one.

Men and women motivated by faith have every right and obligation to bring their belief and commitment to the public debate. However, that is very different from the governmental establishment of religion that our founders warned against and our constitution prohibits.

I get a lot of criticism for telling founders to focus first on making something great, instead of worrying about how to make money. And yet that is exactly what Google did. And Apple, for that matter. You'd think examples like that would be enough to convince people.

People are still very focused on the startup story: Risk-taking founders, with a bold idea, some capital and a network supportive environment, go out and take the shot on goal. But the problem is, this is no longer the truth about what makes Silicon Valley so special.

Life inside successful Web startups - especially the really successful ones - can be nasty, brutish, and short. As companies grow exponentially, egos clash, investors jockey for control, and business complexities rapidly exceed the managerial abilities of the founders.

Dubois was the first black American to graduate from Harvard. He was accepted within the northern white intellectual circles as one of the 'best of his race.' As an avowed socialist, he was the only black member of the original 19 wealthy socialist founders of the NAACP.

I tell the story of eight forgotten founders, people like Canassatego, an Iroquois Indian Chief, who taught Benjamin Franklin about federalism, about the idea that you can form a confederacy in which the central power has only limited powers and local control is retained.

When I meet with the founders of a new company, my advice is almost always, 'Do fewer things.' It's true of partnerships, marketing opportunities, anything that's taking up your time. The vast majority of things are distractions, and very few really matter to your success.

If Obamacare is allowed to stand - and Congress is allowed to make the purchase of government-endorsed health insurance compulsory - there will be no meaningful limit on Washington's reach into the lives of the American people. That is certainly not what the Founders intended.

The founders of a new colony, whatever Utopia of human virtue and happiness they might originally project, have invariably recognized it among their earliest practical necessities to allot a portion of the virgin soil as a cemetery, and another portion as the site of a prison.

The American people voted for a president, Donald Trump, who's very tough, very strong, very aggressive on terrorism, but at the same time smart. At the same time sophisticated. At the same time, heeding the wisdom of our founders who warned about entangling foreign engagement.

The Senate was an odd compromise between the founders and the early leaders of the republic who wanted a single house which was based on popular sovereignty representing the people and those founders who wanted two houses, the upper house, the Senate, being the more aristocratic.

Our Founders warned against this. They said don't... that your liberty is only as secure as the people are. Because once they, um, get the ability to vote themselves entitlements from the largesse of the government, liberty is done; freedom is over with. We were warned. We are there.

As an immigrant, my wish is that we fix immigration. At Sequoia, we've backed a number of exceptional founders that were born abroad but started their careers in the Valley. They've created immense value, but more importantly, massive numbers of jobs locally, nationally and globally.

We have this powerful lever at Google Ventures, which is to invest $200 million a year. This is a huge lever. It's not all going into one place; it's going into lots of start ups and founders and entrepreneurs, all of which are levers to try and change the world in one way or another.

Our Founders worried a lot about the tyranny of the majority. They designed our form of government to provide a loud voice for minority points of view. They hated the idea of unilateral power. And wanted to force advocates and policy makers, through structure and process, to compromise.

We always talk about how you have to build a brand from the inside out, not the outside in. Brands are not wrappers. Brands are based on the values of the founders, and then they spread to the people who work for the company, and then that psychological contract is spread to the customer.

Books about technology start-ups have a pattern. First, there's the grand vision of the founders, then the heroic journey of producing new worlds from all-night coding and caffeine abuse, and finally, the grand finale: immense wealth and secular sainthood. Let's call it the Jobs Narrative.

When I look at founders and CEOs like Mark Zuckerberg at Facebook and Brian Chesky at Airbnb and Sebastian Thrun at Udacity, these are companies that are creating extraordinary social good and extraordinary economic and educational empowerment, all within with context of a for-profit model.

Conservatives, in general, are anti-immigrant for the same reasons they have always been anti-immigrant - a proud tradition in our nation of immigrants going back to the days of the Founders, when Ben Franklin thought we were going to be overrun by Germans. But Business likes illegal workers.

You can't always say what's popular and you ought to go with it. I think that's why the founders were concerned about direct democracy. That's why we have a republic and that's why we have representatives who who are supposed to look at the issues and to look out for the next generation as well.

I am convinced that the Obama administration and Clinton Dynasty would rather hail the Communist Manifesto than the Declaration of Independence this Fourth of July. And there's more than enough proof to show how they have been slow-cooking our Founders' republic into a red-star state like China.

There are some who invoke separation of church and state - to try to get the government out of the business of morality - but this is antithetical to what the founders wanted. The founders wanted to keep theology out of government so that government could focus on the proper business of morality.

The biggest start-up successes - from Henry Ford to Bill Gates to Mark Zuckerberg - were pioneered by people from solidly middle-class backgrounds. These founders were not wealthy when they began. They were hungry for success, but knew they had a solid support system to fall back on if they failed.

There are two companies that the AI Fund has invested in - Woebot and Landing AI - and the AI Fund has a number of internal teams working on new projects. We usually bring in people as employees, work with them to turn ideas into startups, then have the entrepreneurs go into the startup as founders.

For a lot of people, one of the reasons they don't like to work for founders of startups is that they can be sensitive and protective around what they've built. You have an emotional attachment to the early marketing and technology materials, and you don't want to hear that anything's wrong with them.

Our model is very, very different to LinkedIn. We only deal with very small companies. We don't have any support for recruiters. In fact, recruiters are not supposed to be on AngelList Talent. It's a direct market where we connect CEOs and the founders and the head of products with their talent directly.

If the founders of a start-up are considering selling it, I'd advise them to consider the synergies. Could the buyer give you access to something you don't have now, like a certain technology? Would it make your life easier? Are you looking for a change? Things will change, so you have to be ready for that.

There are certain historical figures of such importance that we need to know everything about them, which is why books about Napoleon, Lincoln, Julius Caesar, Joan of Arc, Queen Elizabeth I, and the great religious founders continue to proliferate; these lives require constant reevaluation and interpretation.

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