Stasis is something that has marked my life since I was a boy growing up in Pittsburgh with my mother. It was the natural state that we existed in. For one thing, she suffered from a debilitating depression throughout my childhood, and depression is nothing if not static.

Science offers the chance to cure debilitating and once-intractable disorders like hemophilia and sickle cell disease. But we need to make sure the ability to access these therapies, or the risk that someone can be locked out of them, doesn't widen gaps between the rich and poor.

I did not have a car in high school and neither did Angelina. Try to imagine. You go to Beverly Hills High, one of the wealthiest high schools in the nation. Even the cheapest car that anyone has is brand new. All my friends are well off. I have a movie-star father and no car. It was debilitating.

We have all witnessed, as well, family, friends, or medical workers who have chosen to provide years of loving care to persons who may suffer from Alzheimer's or other debilitating illnesses precisely because they are human persons, not because doing so instrumentally advances some other hidden objective.

My father passed away after three years of debilitating disease, which transformed a very strong and bright man into a real wreck. And that is hard. You have to get out of that stronger, if you can, which I was lucky to be able to. I was the eldest of the family, and I had to support my mother and help my brothers.

Asylum is for people fleeing persecution, not those searching for a better job. Yet our broken system - with its debilitating court rulings, a crushing backlog, and gaping loopholes - allows illegal migrants to get into our country anyway and for whatever reason they want. This gaming of the system is unacceptable.

I can probably earn more in an hour of writing or even teaching than I could save in a whole week of cooking. Specialization is undeniably a powerful social and economic force. And yet it is also debilitating. It breeds helplessness, dependence, and ignorance and, eventually, it undermines any sense of responsibility.

Being cold is not debilitating. We learned that from the Eskimos. They could be cold, and they could function. And you could function better when you're cold than when you're hot. I mean, hot, you become overheated, and, you know, you lose energy. If you're cold, you could function being cold. Now, frozen is different.

My life changed irrevocably four-and-a-half years ago when my spine failed and collapsed. I spent two years on the floor, in excruciating, debilitating and unrelenting pain. I can only describe the pain as being submerged into a vat of scalding acid that has an electric current running through it. And you can never get out, ever.

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