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Every batch of sperm represents an opportunity for genetic typos - called de novo mutations - to be passed on. A 20-year-old man and woman will each pass on about 20 de novo mutations to a baby they conceive. By the time the couple is 40, a woman's total has remained at 20, while a man's has jumped to 65 - and it keeps climbing from there.
A couple of months ago, I was down in Florida for the Food and Wine Festival. And this journalist grabbed me and said, 'How does it feel to be a TV guy? You're no longer in the restaurant business.' And I laughed. I asked him, 'How long do you think it takes me to do a season?' He said, 'Well, 200 days.' And I was like, '200 days? Try 20!'
If that were God's plan, it's a bad bargain; I don't want to have to deal with a God like that...My sense is God and I came to an accommodation with each other a couple of decades ago, where he's gotten used to the things that I'm not capable of and I've come to terms with things he's not capable of...and we care very much about each other.
I am endlessly fascinated that playing football is considered a training ground for leadership, but raising children isn't. Hey, it made me a better leader: you have to take a lot of people's needs into account; you have to look down the road. Trying to negotiate getting a couple of kids to watch the same TV show requires serious diplomacy.
It's not the '80s any more. We're not all riding around in limousines and snorting coke off of hookers' tits. We still have to keep working and touring. We're definitely still very much a working band. If we stopped doing this tomorrow, we'd have a little bit of cash to last us a couple of months, and then we'd have to go and get other jobs.
One of the characteristics of love relationships that flower is a relatively high degree of mutual self-disclosure - a willingness to let our partner enter into the interior of our private world and a genuine interest in the private world of that partner. Couples in love tend to show more of themselves to each other than to any other person.
We have a lot of argument about laws but none of it solves the problem. Let's examine what happened, why did we miss the Tsarnaev brothers, why did we miss the San Bernardino couple? It wasn't because we had stopped collected metadata it was because, I think, as someone who comes from the technology world, we were using the wrong algorithms.
Am I a technocrat? Im just a guy who went down to the bookstore and bought a couple of textbooks on TCP/IP, which is the underlying protocol of the Internet, and read them. And then I signed on to a computer, which anyone can do nowadays, and I messed around with it for a few years, and now I know all about it. Does that make me a technocrat?
So, you could often say things are terrible and that accounts for what happened, or things are really bright, and that accounts for what happened. Often, the real explanation for what happened is much more subtle and interesting and involves maybe small shocks or what a couple people did on a Wednesday morning that changed the arc of history.
When I was 19 and at drama school, a couple of friends and I decided to drive from Guildford through France, down to the heel of Italy and then take a ferry to Greece - in an MG Midget. On our second day, in France, we were in a very bad accident and wrote off the car so we had to go home. But we then flew out instead and went island hopping.
I had written rap songs in the early '90s and even did a couple homemade rap songs with my brother in like '88 or '89, but it was just like... I don't even know how to say it. Just plain rap. I was just rapping about whatever, there was no real style or direction, it was just semi-braggadocious rhymes that probably imitated 100 other rappers.
I did have a couple of people asking me to illustrate their MC in a hope to widen the exposure, unfortunately the messages weren't a good fit, so I couldn't oblige. And I didn't really want to become a matchmaking service. Someone posted a missed connection "I like your blog" which was directed at me... that was kind of fun to stumble across.
What I was going for in the first two albums I didn't necessarily achieve. Because I was young and because it was my first time out. And the second album was such a 'quickie' sort of 'Let's just get it over with!' But the kind of music I make, there's a lot of subtlety in it. And I think it takes a couple of listens to actually really get it.
There was a study done in the early 20th century of all the entrepreneurs who entered the automobile industry around the same time as Henry Ford; there were something like 500 automotive companies that got funded, had the internal combustion engine, had the technology, and had the vision. Sixty percent of them folded within a couple of years.
I don't really know why an idea comes to me. But all of a sudden, an idea comes and from experience I can intuit what something means when an interesting line pops up. Or I can intuit what an interesting choice might be. And I can try a couple of different choices, and see which one feels right, and then continue the song to see where it goes.
Jazz celebrates older generations and not just the youth movement. When you "sell" only to people of a certain age, you get cut off from the main body of experience. The power of couple dancing and courtship, it's elegant, and you wouldn't realize America was once a nation of dancers and singers today. People of all races could dance and sing.
There are a lot of little things about our bodies that we all know, but we never talk about. That's what interests me. These are practically universal experiences; nobody mentions them! Some of them are disgusting. Some of them are appallingly revolting and degrading even to the most degenerate mind. So let's get started with a couple of them.
[Clover] secretly hitched a ride with a nice German couple and their new baby...Clover appeared to the baby, so as to be a delightful, soothing surprise. Well, the child did like Clover. In fact, she held him and cooed. When the parents turned around to look at her and saw their child holding a furry, living creature, they needlessly panicked.
I went to Indiana University for college for a couple of years where I double majored in dance and journalism, and after my sophomore year there, I went to the San Francisco Ballet school for the summer, but then they offered me a scholarship to stay for the year. That's where I danced after the year they offered me a contract with the company.
In high school, I had a teacher there who was really great to me and with whom I finally dared to admit I wanted to be a writer myself, and we did a project where I wrote terrible, 17-year-old fiction. But I remember a couple of the stories. I'd love it if I could read with pride something that I wrote that long ago, but it hasn't happened yet.
I feel prematurely old. I'm actually having this major belated quarter-life crisis. I'm turning 30 in a couple of weeks. I've been thinking a lot about mortality. A lot about what I'm going to do with my life and how to enjoy it. One of the things I'm going to work on is being more spontaneous, letting go, embracing the beauty of come-what-may.
To deny an entire group of people the ability to be legal couples is anti-American and anti-freedom. As a devoted husband and father of two, I can't imagine the state of Minnesota not recognizing my love for my wife Isabelle. We would welcome and respect the equal rights for gays to experience the same joy and privileges of marriage that we do.
I've been saying for a couple of years now that people need to let God out of the Sunday morning box, that He doesn't want to just be with you for an hour or two on Sunday morning and then put back in His box to sit there until you have an emergency, but He wants to invade your Monday, Tuesday, Wednesday, Thursday, Friday, Saturday, and Sunday.
My dad has been married to his wife for 15 years and wherever he goes there better be a seat for her. I like real couples that tell you how to get through on Wednesdays when you're just at the end of your rope - the ones who really know how to make it through. We have to stop looking at Hollywood couples because you're going to get disappointed.
I'm really conscious of the amount of food I eat, but I don't deny myself anything. For example, I have a really big sweet tooth. At the end of the night, if I'm craving ice cream, I might not have the bowl that I would have when I was a kid, but I'll put a couple of scoops in a coffee mug, and I'll eat it slowly, and I enjoy every moment of it.
Neither of youIn the couple have to change in order to be with the other. Whether that's having sex with other people or monogamy. The main thing is not having to reconcile your different lives like cutting your hair, changing the way you dress, who you are. The marriage with the guy I was sleeping with was asking me to be someone who wasn't me.
This is ideal, you’ll see. We do everything backward. It’s just how we are. We began with an elopement. After that, we made love. Next, we’ll progress to courting. When we’re old and silver-haired, perhaps we’ll finally get around to flirtation. We’ll make fond eyes at each other over our mugs of gruel. We’ll be the envy of couples half our age.
To allow same-sex couples to adopt children and then to label their families as second-class because the adoptive parents are of the same sex is cruel as well as unconstitutional. Classifying some families, and especially their children, as of lesser value should be repugnant to all those in this nation who profess to believe in "family values."
I grew up on a set. The guys I hung around with were crew guys: the camera department, the prop guys. I was like the third kid through the door when I was a kid actor on Leave It To Beaver. I was always one of five guys who would have a couple lines. I was a journeymen actor in my first career, so I was appreciative of the journeymen on the set.
I saw so many kids 22, 19, with holes the size of a dime and they're dead. It's a gunshot and of course those kids thought they were as tough as nails, they never expected to be dead but they're gone. It's kinda nice to walk out of the County Coroner's Office with a couple of sayings, you know? "You're not so tough being dead on a morgue table."
I think it's silly when people try compartmentalize musical genres. That was always my problem with the chillwave thing - people were trying to make it into some kind of musical movement, when it was not a movement. A couple dudes had a couple songs for a couple months. It's going to be a disparate onslaught of people throwing ideas at the wall.
Australia was once a leader in taking global warming seriously. The former PM [Kevin Rudd] called it 'greatest moral challenge of our time'. But in the past couple of years the national consensus has been eroded and Australians are being encouraged by the polluters and their mates in Parliament to forget it was ever mentioned. It's heartbreaking.
love wasn't possible in just a couple of days. Love could be set in motion quickly, but true love needed time to grow into something strong and enduring. Love was, above all, about commitment and dedication and a belief that spending years with a certain person would create something greater than the sum of what the two can accomplish separately.
In Germany there is ranking for contribution rate, so the cheaper sickness funds with good quality can both advertise their better quality plus their lower contribution rates and therefore be gaining members. We had about 240 sickness funds a couple of months ago; we are now down to 213, I think. In two or three years, only 50 or so will survive.
Impressionists have to paint with a very broad stroke because you've got to see it within a couple of seconds. You go, "That's a really funny Robert De Niro." As an actor, though, you look at different aspects of a character. I try to completely surround myself with the assignment. It's like being in a big cloud and then some of it rains through.
Karl Rove thinks we shouldn’t have Hillary Clinton in the White House because she fell and hit her head a couple years ago, spent three days in the hospital, and maybe she has brain damage. You know, I don’t recall the Republicans being this concerned with mental fitness during the years when Reagan was talking to house plants in the White House.
In fact, on a side note, after the success of the first record, I got asked to write for some pop artists, as everybody does, and I did a couple songs for some of these massive stars and the review that I got back was, "This artist likes the song but it's too POP-y for them." I was like, "What do you mean, I thought I was writing for a pop star."
I found myself sitting at the computer, and I thought I was going to write a kind of simple nostalgic story about two boys and their love of kite fighting. But stories have a will of their own, and this one turned out to be this dark tale about betrayal, loss, regret. The short story which was about 25 pages long sat around for a couple of years.
I look at people holdings hands in the hallways, and I try to think how it all works. At the school dances, I sit in the background, and I tap my toe, and I wonder how many couples will dance to ‘their song.’ In the hallways, I see the girls wearing the guys’ jackets, and I think about the idea of property. And I wonder if anyone is really happy.
There is no lock strong enough nor wall thick enough to keep Death out," he murmured, his lips close to my ear so that I could feel the puff of his breath against my skin. The ends of a couple of his braids had found their way under the collar of my flannel night-shirt and tickled the base of my neck. "Are you speaking literally or metaphorically?
You can tell everybody that Eddie Robinson's out looking for a job right now, and believe me, he's a great kid. He's happy and he's healthy. All he needs is a couple of weeks to regain game fitness. Put him on the court and when the game counts ... Eddie Robinson is about one word: winning and losing. He's a great athlete, and I love him to death.
When I'm writing a book, generally I start with the mood and setting, along with a couple of specific imagesthings that have come into my head, totally abstracted from any narrative, that I've fixated on. After that, I construct a world, or an area, into which that general setting, that atmosphere, and the specific images I've focused on can fit.
Best ever was filming in Barcelona last year, and I had a couple of scenes with De Niro. He's a very shy man. Speaks so quietly that people tend to bend down and adopt the same tone, almost the same voice, whenever they talk to him - watching, you'd think someone's offering to carry out a hit for him when they're just offering him a cup of coffee.
With films, I just scribble a couple of notes for a scene. You don't have to do any writing at all, you just have your notes for the scene, which are written with the actors and the camera in mind. The actual script is a necessity for casting and budgeting, but the end product often doesn't bear much resemblance to the script--at least in my case.
We all support the idea of a strong marriage, we all clearly like a good party. Call us hopeless romantics, call it the triumph of hope over experience - most of us think when people love each other and want to make that long-term commitment, that is a wonderful thing. So why would we stop a loving couple getting married just because they are gay?
There are many options in a marriage. If the couple has been together for a certain amount of time and has a certain amount of liberalism or life experience, it could be the kind of relationship in which one partner ventures into the occasional affair, which is then forgiven. This only happens every 13 years on average, but it obviously does occur.
I've failed so many times in my life that my recovery time has improved. I'm better at redirecting my attention. I've trained in Radical Aliveness and Core Energetics over the past couple of years and that has allowed me to see how much we project our failures onto others. It has taught me to accept myself. There is real power in owning your truth.
I travel 250 days a year. There are chef friends who I only see every couple of years. By conventional standards I'm a bad friend. I'm not there to remember your birthday or to offer you words of support through Twitter. I'm not up on what you're doing in New York because I'm not in New York. I'm not what people call in parenting circles "present."
Loving one another isn’t enough to make a relationship last. The real glue that holds a couple (or friends or family) together is the effort both put into helping others who are in need of financial, health, personal or emotional assistance. Today, sustain your connection to a loved one by finding ways you both can help others, with a genuine heart.
I never did well meeting strangers, so my favorite part of partying as a couple was that I didn't need to strike up conversation from scratch. If you've ever had to go out and meet new people on your own, you would understand. It can be a bit of an awkward situation. If you're already out at a party with someone you know, it takes that pressure off.