Poe had this curious kind of alchemical courage, where he took all the terrible things and terrors that happened in his life, all this shame and fear and pain, and turned them into great works of art. He was a complex, brilliant person who was just wired too tight.

We owe it to consumers to treat their dollars with respect and to double- and triple-check our assumptions about complex marketplaces rather than getting locked into a regulatory tunnel vision that will ultimately leave consumers with fewer, more expensive choices.

While it is true that Frank had a great sense of humor, he was also very serious about composing music. In reality there are only a handful of skilled players who can play his most complex pieces. It takes a lot of patience to learn and requires a fantastic memory.

As biologists, we contemplate with admiration and awe the wondrous array of sophisticated cell interactions and recognitions evolved in the T cell immune system, which must be a model for other similarly complex biological systems of highly differentiated organisms.

Take a sound from whatever source, a note on a violin, a scream, a moan, a creaking door, and there is always this symmetry between the sound basis, which is complex and has numerous characteristics which emerge through a process of comparison within our perception.

The constancy of the blood sugar level is maintained by a complex physiological mechanism, a homeostatic mechanism of the same order as those which maintain the body temperature, the blood pressure or the heart rate at normal levels and control many other functions.

Drug use, within entire teams continues unabated. It is planned and deliberate cheating, with complex methods, sophisticated substances and techniques, and the active complicity of doctors, scientists, team officials and riders. There is nothing accidental about it.

One of the things I love about directing is I love actors, because no matter how complex they are, once you get down to working and talking to them and the toughest guy will want you to open them up and he wants to show you stuff he was afraid to show anybody before.

What I see in the corporate sector is very clearly an issue of a major shortfall in the issue of, what some people call confidence, but whatever you want to call it. Clearly people are looking out in the very distant future and they are saying that it is too complex.

Canada has a passive-aggressive culture, with a lot of sarcasm and righteousness. That went with my weird messianic complex. The ego is a fascinating monster. I was taught from a young age that I had to serve, so that turned into me thinking I had to save the planet.

The innovative process is a fragile one, dependent on a complex, often messy interplay of imagination, competition, and exchange. Curbing new ideas hurts not only individual creators but the audience for which they create and the posterity that inherits their legacy.

Men are at every stage of evolution, from the most barbarous to the most developed; men are found of lofty intelligence, but also of the most unevolved mentality; in one place there is a highly developed and complex civilisation, in another a crude and simple polity.

We have entered an age in which education is not just a luxury permitting some men an advantage over others. It has become a necessity without which a person is defenseless in this complex, industrialized society. We have truly entered the century of the educated man.

I try to present something that is full of time. Not timeless, but full of time. I never like a work where we try to update it, but it's still not interesting to see a work that is dated. If one is successful, then a work can be full of time. And time is very complex.

When distant and unfamiliar and complex things are communicated to great masses of people, the truth suffers a considerable and often a radical distortion. The complex is made over into the simple, the hypothetical into the dogmatic, and the relative into an absolute.

The fundamental laws necessary for the mathematical treatment of a large part of physics and the whole of chemistry are thus completely known, and the difficulty lies only in the fact that application of these laws leads to equations that are too complex to be solved.

Dwight Eisenhower warned American citizens at the end of his presidency about the implications of the military-industrial complex and its influence over government. We have now gone well beyond any of the wildest imaginations that could have entered Eisenhower's mind.

One of the biggest mistakes people make is to think that what you need to write a novel is imagination, creativity and a facility with words. Yes, you need all those things, but a novel is a highly complex organism that needs to be dealt with in quite a logical manner.

If someone knows of a job creator anywhere in the world that's looking for a high, complex tax environment or looking for a high regulatory environment, I would like to meet them because I have yet to meet a job creator that's looking for that, and that's what we have.

The purpose of life is to help others, and if you can't help them, won't you at least not hurt them? I know that is a platitude, that that is sentimental and can easily be attacked. But loving, caring is simple, and we make it complex. Our own neuroses make it complex.

I think my thing is that... I don't know. And that's why I don't wanna sing about 'This is me, this is who I am' because, like, even the question, 'Tell me about yourself' - what are you supposed to say? 'Ooh, I'm a happy girl, but I'm sad, too'? People are so complex.

In the early days of the video game business, everybody played. The question is, what happened? My theory - and I think it's pretty well borne out - is that in the '80s, games got gory, and that lost the women. And then they got complex, and that lost the casual gamer.

It's often been said that politics in Islington, in many ways, begins and ends with housing, and it's not hard to see why. Despite the borough's image of exclusivity - the stereotype that it's all Georgian squares and cappuccino bars - the reality is much more complex.

I think every writer has a book that haunts them, and on some level, every book you write is a reaction to it. 'Lolita' is that book for me. Nabokov's love of wordplay, descriptive detail, artfully complex plots, and his themes of obsession and lost love, are inspiring.

Trying to move the volume of products we're talking about from place to place to get it ultimately into the customer's hands, to price these items, to market these items, I think the retail business is incredibly complex. But if you get it right, it's a beautiful thing.

As experimentation becomes more complex, the need for the co-operation in it of technical elements from outside becomes greater and the modern laboratory tends increasingly to resemble the factory and to employ in its service increasing numbers of purely routine workers.

Rather than studying the most complex form of memory in a very complicated animal, we had to take the most simple form - an implicit form of memory - in a very simple animal. So I began to look around for very simple animals. And I focused in on the marine snail Aplysia.

Every man lives in two realms: the internal and the external. The internal is that realm of spiritual ends expressed in art, literature, morals, and religion. The external is that complex of devices, techniques, mechanisms, and instrumentalities by means of which we live.

Our robots are signing up for online learning. After decades of attempts to program robots to perform complex tasks like flying helicopters or surgical suturing, the new approach is based on observing and recording the motions of human experts as they perform these feats.

My manager lives on my block; four of the apartments in my apartment complex of seven are people I know. It's a really close-knit community, and almost everyone on these few blocks are artists or graphic designers, because we live right on the cusp of a warehouse district.

What I try to do in the book is to trace the chain of relationships running from elementary particles, fundamental building blocks of matter everywhere in the universe, such as quarks, all the way to complex entities, and in particular complex adaptive system like jaguars.

These studies resulted eventually in a complete sequence analysis of the complex from several species, and in the atomic resolution structure of the F catalytic domain of the enzyme from bovine mitochondria, giving new insights into how ATP is made in the biological world.

As a civil servant in charge of the government's Strategy Unit, I brought in many people from outside government, including academia and science, to work in the unit, dissecting and solving complex problems from GM crops to alcohol, nuclear proliferation to schools reform.

Our experience in fooling around with the genes of mice has taught us that many of the traits that interest us are not definite products of specific mutations but emergent phenomena arising from extremely complex interactions between genes, environment, and life experience.

As the financial experts all over the world use machines to unwind Gordian knots of financial arrangements so complex that only machines can make - 'derive' - and trade them, we have to wonder: Are we living in a bad sci-fi movie? Is the Matrix made of credit default swaps?

I remember the first time I read Freud, I was 25 or 30, and I was expecting it to be about the Oedipus complex. But what I actually discovered confirmed my own common experience, that you also had little boys who loved their fathers and little girls who loved their mothers.

A pool at the edge of the ocean is the simplest geometry, yet you feel connected to the sea. In a forest with the mountains in the background, you also feel the connection to nature, yet it's a very complex geometry. I think architecture is about controlling these feelings.

We lived by very complex import and export policies, a very complex industrial licensing regime. Very few people could get licences, which were required right from manufacturing a pin to manufacturing a car, and generally went to people who found favour with the government.

With increasing fervor since the 1980s, sustainability has been the watchword of scientists, environmental activists, and indeed all those concerned about the complex, fragile systems on the sphere we inhabit. It has shaped debates about business, design, and our lifestyles.

Finally, as the digestive canal is a complex system, a series of separate chemical laboratories, I cut the connections between them in order to investigate the course of phenomena in each particular laboratory; thus I resolved the digestive canal into several separate parts.

Stripe is building payment infrastructure for the Web, so we make it easy to accept credit cards online. Before Stripe, the way you'd do this is using the legacy banking structure. It was slow, it was complex, it was expensive. It had this very chilling effect on e-commerce.

Professional services industries like finance, consulting, and legal services are, by definition, meta-industries. That is, they serve to help large companies raise money, buy and sell each other, reorganize, implement new systems, conduct complex transactions, and so forth.

I love telling stories, but I also am more aware now of how complex reality is and how difficult it is to really explain what happened or how I felt. Maybe that sometimes makes me a little bit vague, because I don't want to really put my finger on anything or set it in stone.

Evil is relative - and what I mean by that is that our villains are as complex, as deep and as compelling as any of our heroes. Every antagonist in the DC Universe has a unique darkness, desire and drive. And the reason for being of 'Forever Evil' is to explore that darkness.

The idea of introducing the Seven Seas is absolutely to challenge Aquaman on an emotional and personal level. His responsibility is unification of the world, and that just became a lot more complex when he learns about the fall of Atlantis and the splintering of the kingdoms.

We control health and pathogenicity by complex multi-speciated relationships through symbiosis and synergy. Portable shelters for livestock, along with electric fencing, insure hygienic and sanitary housing and lounging areas, not to mention clean air, sunshine, and exercise.

The soul grows by reincarnation in bodies provided by nature, more complex, more powerful, as the soul unfolds greater and greater faculties. And so the soul climbs upward into the light eternal. And there is no fear for any child of man, for inevitably he climbs towards God.

I need to react to a script, to feel strongly about it in some way. And I need it to be a complex character for sure. And also, I think a lot about what kind of audience there is for the film, what they're looking for and ways to connect with them in the playing of a character.

'Heroine' is about a declining and imbalanced superstar - a very brave and bold role. I wanted to test whether I could carry a role like this. I have given 200 per cent to this role. She's a very complex character, very aggressive, manipulative and bold, yet she's very fragile.

There are surely times when a conservative and a liberal would agree. We would agree on how moral it is to discriminate on the basis of race. There's absolutely no light between those two positions. It becomes a little more complex when you talk about law as opposed to morality.

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