The Les Paul was more challenging because of the weight of it, but the tone was there that the Fender will never have and vice versa. So you have to make a decision as to what you're going to have as your main instrument. After seeing Hendrix, I thought, 'I'll stick with the 'Strat.'

Just like medicine anywhere else, I get to walk through life with people in the midst sometimes of their most difficult and challenging circumstances they've faced - a terminal diagnosis, bad news, poor prognosis - and also the most joyful times with people, like the birth of a new baby.

We are constituted so that simple acts of kindness, such as giving to charity or expressing gratitude, have a positive effect on our long-term moods. The key to the happy life, it seems, is the good life: a life with sustained relationships, challenging work, and connections to community.

To be honest, relationships with the opposite sex are the most challenging things I've done. You lose your compass, gravity changes, you don't know what's up or down, you're trying to figure it out. You're trying to make everybody happy, including yourself, and it's just... it's humbled me.

One of the greatest gifts my father gave me - unintentionally - was witnessing the courage with which he bore adversity. We had a bit of a rollercoaster life with some really challenging financial periods. He was always unshaken, completely tranquil, the same ebullient, laughing, jovial man.

Grittier students are more likely to earn their diplomas; grittier teachers are more effective in the classroom. Grittier soldiers are more likely to complete their training, and grittier salespeople are more likely to keep their jobs. The more challenging the domain, the more grit seems to matter.

What keeps this industry challenging as an actor is that you never know how something will turn out. The ups and downs are constant. You're never just smoothly sailing along. You're always going to be on loose footing. That's what ultimately now I expect and accept and that doesn't scare me as much.

It can be very challenging to be what you can't see. Think about it in the physical world. You walk into a room, and no one looks like you. Can you relate to them? Do you feel welcome? Let's stop talking about how men dominate the technology industry and instead focus on the women who are killing it.

I went into science, ending up with a Ph.D. in cell biology, but along the way I found out that experimental science involves many hours and days and nights of laboratory work, which is a lot like washing dishes, only a little more challenging. I was too impatient, and maybe a little too sloppy, for it.

So when you're following guys like Kyle O'Reilly and Bobby Fish or The Young Bucks or Jay Lethal or The Briscoe Brothers, and you're going out and trying to really stick out and have a very memorable, talked-about main event, or the match of the night, like the main event should be, it's really challenging.

The most important thing to keep in mind is the incredible diversity of talent that's out there - there are so many great actors from all over Asia, from Singapore and Hong Kong to the Philippines and Mainland China, not to mention many great Asian-American actors who are eager for fun and challenging roles.

I believe that good television should be challenging and frustrating and maddening and thrilling. If you just want to see people who look like you and think like you and do what you would do in any given situation, you'd have to stop looking at TV and start looking in a mirror. But would that be as much fun?

Stating my views on Islam has brought me to court on charges of 'group insult' and incitement to racial hatred. I am being tried for voicing opinions that I - and my constituents - consider to be the truth. I am being tried for challenging the views that the ruling establishment wants to impose on us as the truth.

The characters I've played as an actress have been really challenging and emotionally rewarding, but there was just something missing. I was finding over and over again that directors were looking to me to help with troubles on set as far as characters' relationships, special effects and story points were concerned.

What tends to happen when people talk about Chinese sci-fi in the West is that there's a lot of projection. We prefer to think of China as a dystopian world that is challenging American hegemony, so we would like to think that Chinese sci-fi is all either militaristic or dystopian. But that's just not the reality of it.

I had been a veteran of pretty challenging job searches, so I knew firsthand how frustrating, confusing, and demoralizing the job search process can be. Even after you get a job, many people join companies and discover in the first couple weeks that they aren't a good match with the personality and values of the company.

I'd like to do a lot of different stuff. I think it's important as a creative person to keep challenging yourself and keep doing new stuff. If you end up trying to repeat yourself it's death. It just becomes boring and takes the passion out of it. You gotta find stories and characters that you really want to hang out with.

I think it is important to recall the context of those challenging times immediately following 9/11. For me, I had just returned to Washington from an overseas posting and I reported for duty on the morning of 9/11. I knew in my gut when I saw the video of the first plane hitting the tower in Manhattan that it was bin Laden.

Success gives you a platform for further success - suddenly everybody wants to work with you, and your opportunities and possibilities open up. But at the same time, success is also immensely challenging - it ultimately often creates pride, stubbornness, and sloppiness that beget failure, taking down people and organizations.

My parents made it clear that I should never display even the slightest disrespect to individuals who had the power to let me skip a half grade or move into more challenging classes. While it was all right for me to know more about a topic than my sixth-grade teacher had ever learned, questioning her facts could only lead to trouble.

When you're a little kid, you just like music that makes you happy and is fun. As you get older, you reach college or your 20s and you decide that music should be challenging and all art should be smart. So you start to think it makes you like high art more to put down things you consider low art. I don't even think things are low art.

I would have to say the most challenging thing about directing is the sheer stamina because... as a director, you're always doing something. Someone always needs to talk to you. There are always decisions to be made and every day for as long as the movie goes on. So it's a marathon... You don't have to look nice, but it's all day every day.

Dealing with boys at work and being the only girl can be challenging. I have my insecurities, but I've learned I have to be a good sport. I have to be able to take certain jokes and not take them personally. There are jokes made almost every second of the day. I had to develop a tough hide. You know, the music industry is dominated by guys.

A lot of the things I loved the most growing up were, on the surface, kind of challenging or impenetrable. I loved Andy Kaufman, and half his shows, people would walk out in a rage. I love punk rock, which is notoriously music that doesn't always sound very inviting or appealing but, I think, unquestionably has the most heart, the most integrity.

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