The biggest problem is getting beyond the "you can't" syndrome. The moment you figure that out, you're on your way to flying. Anyone who cannot see problems around him or herself is utterly blind. All the problems sitting there are an invitation for you to be creative, make use of your skills and resources and find a solution.

Thomas Jefferson explained, Congress has not unlimited powers to provide for the general welfare, but only those specifically enumerated. .. If Congress can determine what constitutes the general welfare and can appropriate money for its advancement, where is the limitation to carrying into execution whatever can be effected by money?.

In 1962, when I was 19, I visited India. With introductions from people involved in the U.S. civil rights movement, I was able to visit with several of the leading Gandhians there. The hundred-to-one difference in average per capita income between America and India at the time was a stark reality for the people who became my friends there.

Of course you can do it. It doesn't require brilliance. It's just giving yourself permission and then being persistent. Persistent in seeing the problem or opportunity and persistent in thinking about it until you have come up with some interesting ideas that might change the pattern. It's really a mindset, not anything in the objective world - that is the problem.

Amazingly, 85 percent of prescribed standard medical treatments across the board lack scientific validation, according to the New York Times. Richard Smith, editor of the British Medical Journal, suggests that this is partly because only one percent of the articles in medical journals are scientifically sound, and partly because many treatments have never been assessed at all.

What is the most powerful force in the world? And I think you would agree that is a big idea if it is in the hands of an entrepreneur who is actually going to make the idea not only happen, but spread all across society. And we understand that in business but we have need for entrepreneurship just as much in education, human rights, health, and the environment as we do in hotels and steel.

We need to reverse three centuries of walling the for-profit and non-profit sectors off from one another. When you think for-profit and non-profit, you most often think of entities with either zero social return or zero return on capital and zero social return. Clearly, there's some opportunity in the spectrum between those extremes. What's missing is the for-profit finance industry coming in to that area. Look at the enormous diversity of the for-profit financial industry as opposed to monolithic nature of the non-profit world; it's quite astonishing.

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