Antidepressants are the biggest fraud in the world. Number one, Prozac gives you a royal soft-on like you wouldn't believe, and number two you never know all the side effects. I look at the pharmaceutical companies as the drug barons, the psychopharmcologists as the mules and the patients as the victims. They're innocent because they think they're being cured.

When you make the film, it's like a chef who works on the meal. After you're working all day in the kitchen and dicing and cutting and putting the sauces on, you don't want to eat it. That's how I always feel about the films. I work on it for a year. I've written it, I've worked with the actors, I've edited, put the music in. I just never want to see it again.

There is an advantage in having a routine and working with the same people when you can and in writing as a regular thing and filming as a regular thing. That routine pays off for you. You get a lot of productivity that way, rather than sitting around waiting for inspiration and waiting for the perfect thing to happen. I would be much less productive that way.

There are drawbacks in being famous too, but you can live with those. They're not life-threatening. If the paparazzi are outside your restaurant or your house - and actors make such a big thing of it and scurry into cars and drape things - you think they're going to be crucified or something. It's not a big deal. You can get used to that. It's not so terrible.

Real life is generally much duller and inevitably sadder, most of the time. In film, you control everything that's going on, so you can indulge the most fantastic, romantic, escapist feelings and fantasies. You can do anything you want. That's why it's very seductive and pleasurable to earn your living making movies because you're not living in the real world.

I think often people fall into the breadth trap of wanting to do too long a period of time, and obviously there's this sort of algorithm of how much depth you can put into something times how much of their life you're trying to show. My attitude has always been, I'd rather show a briefer period of time in more detail than a longer period of time in less detail.

I enjoy the making of the film and it's something for me to do. If nobody ever comes to my films, if people don't want to give me money to make films, that will stop me. But as long as people come all over the world and I have an audience and I have ideas for films, I will do them for as long as I enjoy the process. And I like the whole process of making a film.

Even if people hate my other movies, and hate me, or whatever, I think from this point of view, Postal is the most important movie after September 11. It's not respecting any edge, any border, any nation, any religion - it's an all-type offender. I think that only if everybody gets a little pissed about something then you will start thinking about your situation.

I’m going to kill myself. I should go to Paris and jump off the Eiffel Tower. I’ll be dead. you know, in fact, if I get the Concorde, I could be dead three hours earlier, which would be perfect. Or wait a minute. It -- with the time change, I could be alive for six hours in New York but dead three hours in Paris. I could get things done, and I could also be dead.

We put in all the great ideas that can be brought into the film [Doctor Strange] in the service of introducing the world to an audience who's never heard of it and doesn't know it from a hole in the wall. And we thought that an inter-dimensional girlfriend that's the daughter of an inter-dimensional demon-esque creature was a step too far in introducing this world.

Being able to just stick to our instincts and honor the [Hunger Games] books and find a way to stay the course of trying to make the best possible decisions that you would make creatively on any movie, without having your head turned too much by all of the interest, has been a great challenge. It's the best challenge you could ask for, but that was a big challenge.

Something economically changed. It used to be that you needed 20 million people to watch a TV show for it to be a hit. Now, with just a few million people watching, you're considered very successful, for a lot of these streaming services, or cable channels. Now, that allows people to do much more creatively ambitious work, because it's not lowest common denominator.

To whom one reports is a unit of measure. It measures the exact distance between the player and the center of power. It is the closest we can get to a calibrated answer to the question 'How big am I?' More than the size of an executive's office or even his title, which no one remembers anyway, the fewer people between the player and a 'yes,' the more powerful he is.

I'll work by myself for years and then I'll think it'll be fun to et one of my friends like Marshall Brickman or Doug McGrath into a room and not be alone for the writing of the thing; to have the pleasure of taking walks and get lunch together; its sort of a fun process and then I do it and then I get back on my own for a while until I feel the need to do it again.

If I'm a director and I read a script and I say yeah I really want to do this, I would never walk away because the deal wasn't very good - that I wasn't getting paid very much or that the chances that I would see anything on the back end were remote because of the financial waterfall and the way it's structured. I would never use that as a reason not to do something.

For me and movies - and it is kind of similar to motherhood and raising your children - I always feel like there's more you can do, and I don't know if that's particularly a female quality. I don't know how dads feel, but there's definitely a never say die, no stone unturned, never give up a minute that you could be pushing it down the road and try to make it better.

There's a real difference between a documentary that was all about facts and history and information. People just don't get as engaged in that kind of documentary - they don't fall in love, they don't cry, they don't forget who they are, they don't ride with you. As we realized we had richer, vérité kind of people, what we wanted to do is focus in on the vérité story.

Don's Mancini father was an advertising executive and I think Don really grew up and all of that stayed in his head. Some of the really great slogans we came up with, over the years, the big advertising buzz-words that we had, Don created those. It's just kind of fun just thinking about what we both love about pop culture and applying it to Chucky film and any others.

This is my perspective and has always been my perspective on life: I have a very grim, pessimistic view of it. I always have, since I was a little boy. It hasn't gotten worse with age or anything. I do feel that it's a grim, painful, nightmarish, meaningless experience, and that the only way that you can be happy is if you tell yourself some lies and deceive yourself.

I feel that life is divided into the horrible and the miserable. That's the two categories. The horrible are like, I don't know, terminal cases, you know, and blind people, crippled. I don't know how they get through life. It's amazing to me. And the miserable is everyone else. So you should be thankful that you're miserable, because that's very lucky, to be miserable.

Everyone is wounded. No one is healthy enough to never screw up, when you're in combat. But, I like to show that, and I like to show how people get back from that. You have to forgive each other. When you're in the middle of a long-term commitment, the essence of it is that everyone is going to have good days and bad days, and it's about how you continue to rejoin forces.

So that's one of the reasons why we took time between the last one and this one, was to make sure that we could do something that we believe could be equal if not better than the last one. In this case we already have ideas of things we're talking about, and I think in a perfect world it will not be a four year break and it will come out significantly sooner than the last.

I was very combative as a creative person at that time [while The Ben Stiller Show]. I didn't understand how to play politics with the studios. I didn't know how to creatively collaborate with the people who were paying the bills, and that came up all the time on every project I was doing, and it took me a really long time to figure out how to collaborate in a healthy way.

People who know and read comics know that there's a huge diversity amongst the types of stories. Nobody ever goes 'how many more of these movies based on novels are there going to be?!'. People laugh at that question and they go novels, there are all different types of novels. But there are all different types of comic books, they just happen to have drawings on the cover!

In Germany, people are saying, "George W. Bush is an asshole. Osama Bin Laden is an asshole." But then I make jokes about Auschwitz, and how the Germans are lederhosen-wearing sausage freaks - and they hate me for this! And I'm like, "You all are sitting there because you want to relax and have a nice evening, and now you're pissed because I put also a mirror in front of you."

I just felt like, you know, I read a lot of scripts out in L.A., out here in the industry and I just felt like this film was just being genuine. I just felt like it had really great characters. And all the three different characters have completely different stories and they're all kind of intertwined together thematically. So I just thought it had great characters, great themes

When I started, every film got a full theatrical distribution. Today, almost no low budget films, maybe two or three a year, will get a full theatrical distribution. We've been frozen out of that, which means they must be aware that for a full theatrical distribution it either has to be something like Saw or some exploitation film of today or an extremely well made personal film.

There is no advantage getting older. You don't get smarter, you don't get wiser, you don't get more mellow, you don't get more kindly, nothing good happens. Your back hurts more, you get more indigestion, your eyesight isn't as good, you need a hearing aid. It's a bad business getting old and I would advise you not to do it if you can avoid it. It doesn't have a romantic quality.

First, it is providing a means whereby key individuals on its payroll are able to obtain both power and wealth through granting special favors to certain politically influential groups that are subject to its regulation. This activity is similar to the 'protection racket' of organized crime: for a price, one can induce FDA administrators to provide 'protection' from the FDA itself.

At network television you could make a show like Freaks and Geeks, and even though 7 million people watch is every week, you were considered a terrible failure, and they got rid of you and staff. Now ... It's like a world where the replacements are the biggest fans in the world. It's, the Elvis Costellos of television are the winners. Creativity is king and it's very very exciting.

If I was one of the leaders...if I was just a leader of one of these studios what I would do is I would go to all my cohorts who run other studios and say let's make a deal. Let's each of us make three 3D movies a year or whatever the number is. Let's not take every movie and make it a 3D movie. Let's take our three tentpoles or whatever movie it is so you have a specialness to it.

The crazy thing is, I sent out 200 letters and I got one job interview, and I actually got that job, which was working as a development assistant at Joel Silver's company. I always say that to people when they ask "What do I do?" and I'm like, "Look, I didn't get ten responses, and I didn't get five interviews, but I got one interview, and I got the job," and that was all I needed.

For me it's much more like a little kid rebelling. The minute I was told what to do at any age, I did the opposite. Hopefully I'll do that for the rest of my life. I come from the business side and Mark comes from the creative side, but every time a decision came up about Creep it was two emails, and we agreed. I've not had that ever with someone on the creative or the business side.

As I've gotten older, the parts have diminished. I liked it when I was younger, I could always play the lead in the movie and I could do all the romantic scenes with the women, and it was fun and I liked to play that. Now, I'm older and I'm reduced to playing the backstage doorman or the uncle or something. I don't really love that so occasionally, when a part comes up, I'll play it.

This guy goes to a psychiatrist and says, Doc, my brother’s crazy. He thinks he’s a chicken. The doctor says, Well, why don’t you turn him in? And the guy says, I would but I need the eggs. Well I guess that’s pretty much how I feel about relationships. You know they’re totally irrational and crazy and absurd but I guess we keep going through it because, uh, most of us need the eggs.

Everybody says video-game adaptations are all the same, but I disagree. Normally, video-game adaptations are like Alone In The Dark, Resident Evil, Alien Vs. Predator - sci-fi creature stuff. But I think I've covered] a wide range of genres and time periods, like Transylvania in 1700 and now a Western with BlodRayne II, or adventure with Dungeon Siege, or comedy and satire with Postal.

You don't need any courage today in Germany to make a movie about the Nazi time. You get all the subsidies, you get the TV stations, you get the good reviews. But you need courage to kick in the balls all the people that are still hiding under the blanket, and to say, "Oh, Adolf Hitler was maybe not so bad." And with my little Nazi jokes in Postal, I offended the Germans in a harsh time.

One of the top challenges is the fact that you are dealing with survivors. Every time you deal with a documentary film subject it is fraught with obvious minefields but when you are dealing with a population that is severely traumatized and trying to recover from that trauma there is an extra level of vigilance and care and attention that has to be implemented all the time at every level.

I think that it's fear. The musicians themselves don't seem to know enough about why they're in the positions they're in, so they're afraid to lose those positions. If you're 22 years old and you can't believe you're even in the position to have a career making music, the first thing you're going to think is: Maintain. Don't lose it. And that's precisely what causes you to lose everything.

As a Jewish man who has no interest in Judaism whatsoever, there's something in me that says when bad things have happened in the past, people were supposed to get more active and speak up and prevent them. That's what's important to me is that everybody - and I don't care what side you're on. You can disagree with me, but everyone better get active. Everybody better vote and be thoughtful.

Watching shows on Netflix is a different experience because most people are sitting there for three to five hours. Very few people even watch one episode. So it's not like a movie theater where you want to the movies to be shorter so you can go urinate. You can pause and urinate at home, and if something is longer, you're allowed to stop and eat breakfast and then watch eight more episodes.

I think any musical has so many moving parts and the challenge is unifying all the moving parts in particular because you have the camera and now it's all about adaptation and what works in one medium doesn't necessarily work in another so the challenge is to stay as true as you can to the material and yet not be afraid to step out of it and add elements to make it satisfying cinematically.

The challenge in any musical is unifying all the moving parts of it, in particular a movie musical because now you're adding the camera and you're adding the idea of adaptation. So the challenge is to stay as true as you can to the material that you love and yet not be afraid to step outside of it and introduce elements into it that make it exist in a satisfying, exciting way cinematically.

You can't work at a relationship; you can't control it. You have to be lucky and go through your life. If you are not lucky you have to be prepared for some degree of suffering. That's why most relationships are very difficult and have some degree of pain. People stay together because of inertia, they don't have the energy. Because they are frightened of being lonely, or they have children.

I can understand that an audience, buying a ticket to see a picture of mine, wants to see something funny because they feel confident that at least I have a fighting chance to make a funny film when I make a film, whereas if I make a dramatic film there's one chance in a thousand that it's really going to come out great, so I understand how they feel about that and they're completely right.

Somebody asked me, "When was the last time it was harder for you as a woman"? And I was like, "What time is it? Do you mean today?" I hate to say that, because it sounds so depressing, but it absolutely happens in many many ways all the time, large and small ways. But it's not like it creates new pain for me on a daily basis, it's just a pain that I accepted long ago. It's definitely harder.

You can learn technological things, you can learn about specific things, but the real problems that people deal with in any subject, existential subjects or romantic subjects, you never learn anything. So you make a fool of yourself when you're 20, you make a fool of yourself at 40, at 60 at 80. The ancient Greeks were dealing with these problems. They screwed up all the time. People do now.

If I was to see any of my films now I would feel, oh god you know it's awful I could do that so much better now. Look at all the terrible things I did and all the mistakes and all the compromises and all the blunders I made, and it would be such a terrible experience for me to see them. So it's better that I put it out and move on to the next thing and make it history as quickly as possible.

Although life is a continuous process, fertilization is a critical landmark because, under ordinary circumstances, a new, genetically distinct human organism is thereby formed.... The combination of 23 chromosomes present in each pronucleus results in 46 chromosomes in the zygote. Thus the diploid number is restored and the embryonic genome is formed. The embryo now exists as a genetic unity.

I have a number of symptoms that are neurotic and are constricting in the sense that if I had a brilliant idea for a film that had to be shot in Tulsa, OK I would tear it up and throw it away. Anything outside of New York, 'cause I can't exist in a hotel outside of my own home, I have to be in my own home and my own environment. This is a neurotic symptom that is constricting to my work even.

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