If I've learned anything in the more than 50 years that I've led MDA, it's that the generosity of the American people knows no bounds. I'm sure that with their fellow citizens in such dire need, they'll dig deep and do everything they can to help. I'm hopeful that many people will be willing to make two phone calls and donate to both causes.

In Vegas, you have an audience you can't find anywhere else. It's from all over the country. You play Seattle, everyone's from Seattle. But in Vegas, you have six from Seattle, a bunch from L.A., some local Las Vegans and maybe a farmer from Iowa. In Vegas, you learn the ins and outs of holding a room because of that great spectrum of folks.

My sister Wendy has a husband and two children, and they have a family photo on top of the VCR, where they're all looking slightly to the left. As though something is going on over there! I guess something happened over to the left that made everybody happy! Except my sister is cross-eyed, so she can't quite pull it off. One eye is right-on.

I'd quite like to write a book about comics, actually. But trying to write about comics as literature, which I don't think anyone's really done before. Sometimes they're more like fan books, and I'd quite like to write one about the Marvel universe over the last 50 years. It's an unprecedented achievement to create that length of continuity.

I think making friends is not being afraid to look stupid, because everyone wants a friend who is willing to be stupid and fun. If you try and be too cool, it only works in high school. After that, being uncool is a very cool thing to do. So just have fun, and don't worry what other people think of you and people will want to be your friends.

It doesn't make any difference how much money a father earns, his name is always Dad-Can-I.... Like all other children, my five have one great talent: they are gifted beggars. Not one of them ever ran into the room, looked up at me, and said, "I'm really happy that you're my father, and as a tangible token of my appreciation, here's a dollar.

The Death Star is just full of British actors opening doors and going,Oh... I... oh... What is it Lieutenant Sebastian? It's just the Rebels, sir... they're here. My God, man! Do they want tea? No, I think they're after something a bit more than that, sir. I don't know what it is, but they've brought a flag. Damn, that's dash cunning of them.

I always had a Twitter account. I always had an Instagram account. I was always active on it, always spoke my mind. To me, it's really weird that I got so many followers and people that pay attention the way they do. It's hilarious, actually, because people didn't used to listen to me at all. I used to be like, "Does anybody hear me talkin'?"

I didn't make any kind of grades in high school. My mother was a single mom, putting my three sisters through college, and I was such a bad student that I knew I had no right to take her money. But I loved being in classes and learning. I took in a huge amount of what I learned, but I had a feeling of always being behind and being in trouble.

We humans are naturally disposed to worship gods and heroes, to build our pantheons and valhallas. I would rather see that impulse directed into the adoration of daft singers, thicko footballers and air-headed screen actors than into the veneration of dogmatic zealots, fanatical preachers, militant politicians and rabid cultural commentators.

When we talk about values, I think of rationality in solving problems. That's something I value. Fairness, kindness, generosity, tolerance. That's different. When they [Conservative right wing Republicans] talk about values, they're talking about things like going to church, voting for Bush, being loyal to Jesus, praying. These are not values.

Do you think if it was the fairy tale about a man who lived inside of a whale and it was religion that Jack built a beanstalk today, you would know the difference? Why do you believe in one fairy tale and not the other? Just because adults told you it was true and they scared you into believing it, at pain of death, at pain of burning in hell.

I just feel like, for me personally, there's just been so much election fatigue, and while I think it was very important during the election to always be on top of everything that was going on with the election via social media, I do feel like, all right, now we need a little bit of a detox. I think people need a little bit of a break from it.

In the future we will all be famous for 15 minutes. It will be on a daytime magazine programme and we will each wear a tasteful shirt and slacks combination. We'll be interviewed by a soothing voice under a clock that's permanently set to 4pm. We will talk about the weather. We will record for months to get 15 minutes they can use in the edit.

There are a lot of little things about our bodies that we all know, but we never talk about. That's what interests me. These are practically universal experiences; nobody mentions them! Some of them are disgusting. Some of them are appallingly revolting and degrading even to the most degenerate mind. So let's get started with a couple of them.

Anyone buying this book is going to be out a tidy sum if he is sucked in by the title. I wish I could write a real sexy book that would be barred from the mails. Apparently nothing whets a reader's appetite for literature more than the news that the author has been thrown into a federal pokey for disturbing the libido of millions of Americans.

The whole - it's the economy's bad. It's bad for everybody. I have my own comedy club. I opened it three years ago in a horrible economy. I created jobs. And we just started breaking even after a year and a half, barely. For that entire time, I have had to pay the difference of what we owe in rent and taxes and everything out of my own pocket.

I'm happy doing stand-up, but I'll probably do a television show eventually. If not, I'll delve into this Internet world and decide best how to harness it. What I like best about it is the independent movie style and the ability to just be completely reckless within that world. I like that a lot. I just have to acquaint myself with technology.

I get so sick of people asking: "What's your demographic?" Or: "Oh we've got to aim this at..." No, you have to aim it at you. You do the thing you would love... make the thing you would love and be proud of. There's enough people in the world that, if you do that and do it well as a single vision, they'll go: "That's my favourite thing ever!"

Republicans say that sex is bad, because with them it always is. It is!...I'm sorry, but they're just doughy, asexual, wonky, white people, and if you had to have sex with them it would be over in an excruciating three minutes. It's just, - and from the headlines of the past year I gather the only sex they're really good at, is gay sex. Really.

I don't consider myself a cynic. I think of myself as a skeptic and a realist. But I understand the word "cynic" has more than one meaning, and I see how I could be seen as cynical. "George, you're cynical." Well, you know, they say if you scratch a cynic you find a disappointed idealist. And perhaps the flame still flickers a little, you know?

Sometimes when my fans come up to me, they think it's going to be entertaining, like I'm going to tell jokes or do bits, and then instead of that I end up talking about really mundane things with my fans, and then they're kind of like, "This is boring. I want to go talk to somebody else." I think I bore my fans to death by over-talking to them.

Media is so weird; everything is so accessible now. It used to be this thing where, if you did something on 'This American Life,' this predates me, but when David Sedaris did it, for example, it would just play, people who heard it heard it, and then the book would come out a year later, and people would be like, 'Ahh, I kind of remember that.'

The film-maker Alejandro Jodorowsky - his films are hard to watch - they're so dense and rich - but they're probably the best things ever made. And Spike Milligan, who was light years ahead of the rest - I played some of his stuff to Jack Black once. He'd never heard of him, so watching him listen to Spike for the first time was just hilarious.

If you want to devote yourself to the arts, you'd better do it strictly from passion, because there is zero guarantee that you'll get anywhere. The hardest thing is dealing with business people who have nothing to do with your art. They could care less that you're up at 4:30 in the morning writing a joke. Don't expect any sympathy from anybody.

To me, in life, if there's, like, a rule, and I think it's ridiculous, then of course I'll circumvent that but also point out how ridiculous the rule is. Other than that, if I go to a concert, and my seat is Row G, Seat 12, I'm sitting in Row G, Seat 12. I don't care if I'm with five other friends, I'm supposed to be in Seat 12, that's my seat.

This is where we are at right now, as a whole. No one is left out of the loop. We are experiencing a reality based on a thin veneer of lies and illusions. A world where greed is our God and wisdom is sin, where division is key and unity is fantasy, where the ego-driven cleverness of the mind is praised, rather than the intelligence of the heart.

When it comes to religion, we're not two sides of the same coin, and you don't get to put your unreason up on the same shelf with my reason. Your stuff has to go over there, on the shelf with Zeus and Thor and the Kraken, with the stuff that is not evidence-based, stuff that religious people never change their mind about, no matter what happens.

It's so easy to demagogue the issue and make someone who speaks out against the internal-combustion engine sound like an insane communist, when the truth is that the internal-combustion engine is the biggest threat to my life in the next 25 years, in terms of what it's doing to our environment and how it's depleting the ozone layer and so forth.

I feel like women are frequently seen as guests in the comedy world - you know, a kid sister of the “real comedians”. I like the idea of positioning myself as legendary rather than trying to fit in. Now do I see myself like that every day? No, but I think it's a funny attitude and maybe on some weird, spiritual level, maybe it's a good attitude.

There's a one in six billion chance you'll find your soul mate. And that's if they're not dead. At best they're probably living in some Siberian ice cave eating bugs and weaving beads into their back hair. But they're out there. My dad believed that to find your perfect soul mate, first, you had to look through a bunch of other guys' soul mates.

I live in New York and there are a lot of famous... pizzerias in my neighborhood, it's really hard to find one that isn't famous. Which sucks sometimes, you know what I mean, sometimes I don't want all that glitz and glamour, I just want something delicious, you know? I don't need a celebrity in my mouth, Ray's Up And Coming Pizza would be fine.

When I trip, I feel like that's the world saying come here for a second. It just pulls me closer for a second, yeah what do you want? I just want to remind you that you're uncoordinated. I'm aware of that, thank you... can I go now? Yeah, you can go, but never ever try to outrun me. Ok, world, see you later. Yeah, I'll see you in about 50 years.

Contribute to the world. Help people. Help one person. Help someone cross the street today. Help someone with directions unless you have a terrible sense of direction. Help someone who is trying to help you. Just help. Make an impact. Show someone you care. Say yes instead of no. Say something nice. Smile. Make eye contact. Hug. Kiss. Get naked.

I think there's a little more attention to human needs than to property rights. But I don't think much of political activism. It's so shortsighted. Most people are interested in their own personal comfort. I've said that about environmentalists. I think they care about bike paths and places to park their Volvos, not the planet as an abstraction.

Well, I don't ever get excited. I haven't been excited since I got a Chopper bicycle when I was about 12. Once you get older you realise there's always a catch to everything. So when I get, say, a commission to make a TV show, the catch is that you have to deliver something and then the sense of responsibility overwhelms the joy of the occasion.

Oh, here's your tax dollars at work. This is what makes people furious. The head of the GSA, a woman named Martha Johnson, has resigned after they found out she spent over $830,000 on a four-day government conference in Las Vegas. And the president is furious. Not President Obama, the president of China. It's his money. It's his money she spent.

I was watching Animal Planet. Did you know that the male seahorse has the baby? And I was thinking, "Why don't they just call that the female seahorse?" You know it's just some stubborn scientist. "Yeah, that one there's the male seahorse." And his assistant's like, "Uh, Bill, that one's having a baby." ... "The male has the baby. You're fired."

There's no reason to tweet when you are in the midst of a great moment; they are few and far between. So pay attention to it, as you probably won't see it again. You can always tweet later, if you're lucky enough to be part of history and you think 140 characters can do credit to someone like Martin Luther King or to the speech he made that day.

My dad has been married to his wife for 15 years and wherever he goes there better be a seat for her. I like real couples that tell you how to get through on Wednesdays when you're just at the end of your rope - the ones who really know how to make it through. We have to stop looking at Hollywood couples because you're going to get disappointed.

Cheat? Good heavens, this is an amateur cricket match amongst leading prep schools, I'm an Englishman and a schoolmaster supposedly setting an example to his young charges. We are playing the most artistic and beautiful game ever devised. Of course I'll cunting well cheat. Now, give me my robe and put on my crown. I have immortal longings in me.

Well, one of the things we felt was missing from the greater conversation is that transgender people have been living and working in America for years...People may think it's a "new" thing; it's not...So we wanted to show not just the political side, which is what you see with Caitlyn Jenner. And not the other side with Laverne Cox, who's great.

My mother was the one who totally got behind me as far as, do things and ask questions later. My father would say, "I don't care how dirty you are up there, just be funny." Because they knew me offstage. They knew I was a good guy. They knew my whole plan of becoming the most exciting comedian, visually, ever. A real rock-and-roll stand-up comic.

Karl Rove thinks we shouldn’t have Hillary Clinton in the White House because she fell and hit her head a couple years ago, spent three days in the hospital, and maybe she has brain damage. You know, I don’t recall the Republicans being this concerned with mental fitness during the years when Reagan was talking to house plants in the White House.

They are having a panel look into the intelligence failures in Iraq. It is a seven-person panel and it will include Senator John McCain, but the findings from this panel will not be issued until after the election. President Bush says the commission can go off and report back in a year, you know, the same way it works in the Texas National Guard.

Full House was a show that was done for ten-year-olds. The critics hated it. They said terrible, terrible things about it. But it should have been reviewed by ten-year-olds. That's who it was made for. They loved it. And if they loved it, great. Why the hell does a fifty-year-old guy working at a big newspaper have to tell me I'm a piece of crap?

I thought yoga was easy - I went out and I bought a yoga video tape. I bought the beginners' yoga tape. I couldn't do anything on the whole hour - nothing - just fast forwarding: can't do that, can't do that - I know I can't do that. This woman in a soothing voice: 'Simply take the bottom of your right foot and place it on the small of your back.

Religion is the yeast of death cakes. It is the most awful agent on a vulnerable mind. It's the refuge of alienated and lonely people. It's what people had before television. It yokes people together into an imaginary world. It is just people talking to their imaginary friends, at length. I wouldn't mind, but some of the people are world leaders.

The first house I bought was a little Spanish bungalow on Clinton Street in West Hollywood, right behind the Improv. I was renting it, and I asked the owners if I could buy it, and they were really nice and let me work out a deal. And I fixed it up and later sold it. That was when I realized that if you make some improvements, you can make money.

Cancer changes your life, often for the better. You learn what's important, you learn to prioritize, and you learn not to waste your time. You tell people you love them. My friend Gilda Radner used to say, 'If it wasn't for the downside, having cancer would be the best thing and everyone would want it.' That's true. If it wasn't for the downside.

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