My childhood best friend is an anesthesiologist. It's the least amount of human interaction for a doctor. I don't think you can get that burned out on it.

Every morning I hear the alarm, it's like "BEEP BEEP BEEP" For second I'm like, "I could get used to that, just dream I'm in a techno club, or something."

If the show is going really well and the comedian is still annoyed with the audience, chances are he's a Boston comic. That's the beauty of Boston comics.

After a gig I always head back to the hotel, remembering granny's words of wisdom. I cancel the late-night pizza and watch the Jonathan Ross show instead.

Then a friend of Jim's suggested we make a theme song to explain the story, and this is where the Mads came from. Josh and I wrote it into the theme song.

Some comedians love their characters. I don't fall in love with mine. In fact, I get tired of them very fast. You have to be willing to throw it all away.

I've always felt that a really good joke, a really good one-liner, is a really good line of poetry. It's imagistic, it's compact, there is a rhythm to it.

There was a time where I knew I was as funny as many dudes, but I had people telling me, 'You have to wear a dress onstage. You need to be more feminine.'

I've always been a social network retard, even before there was a social network. People would say, "You want to go to this party and do some networking?"

I don't like waking up. I feel like staying in bed usually, but I can't because I've got two kids standing next to my bed, just eager to live another day.

I find that when people laugh really hard, it's usually because they're connecting and identifying in a way that they hadn't considered. That's my payoff.

In estimating the adversities of life, we would seldom have much reason to complain of the evils we suffer, did we understand the dangers we daily escape.

It is often better to be restricted to necessity than unconfined in the measure of our desires: prosperity destroys more individuals than adversity ruins.

You're trying your best to make people laugh; then if you fail, they hate you. But your intent's the same. It's not like you're trying to do evil to them.

You can fool some of the people all of the time and all of the people some of the time, but you can only make a monkey out of the voters every four years!

I really had to imagine the kind of person that I would have been if I had never left my hometown. I don't think I would have been a very pleasant person.

Learning lines is on my mind until I do know them. I'll read the paper or paint the house to keep from starting to memorize. I've never found an easy way.

When you work in movies, or on TV shows, there are 50 other people involved. And it's hard, man. They brainwash you to think you're doing the right thing.

I was directing before I started doing 'The IT Crowd.' It wasn't something that led on after acting I guess. I was sort of doing this stuff before acting.

If David Brent is the best thing that I ever come up with, then so be it. What are you supposed to do, time the best thing you do for just before you die?

The word 'aerobics' came about when the gym instructors got together and said: If we're going to charge $10 an hour, we can't call it Jumping up and down.

I was an ugly child. I got lost on the beach. I asked a cop if he could find my parents. He said, 'I don't know. There's lots of places for them to hide'.

Getting older is tough. I remember the last time I felt an erection. It was at the movies. The only trouble is, it belonged to the guy sitting next to me.

I'm all sentimental. I've probably been ruined by romantic movies, but I really do believe in love. I've experienced it, I've had it, so I know it's real.

I'm just so against kids being on Twitter because they are not thinking about the ramifications of what they are saying or the emotion of how they say it.

When I was a kid, I never did funny things to get attention. I was never a funny person. I was never, like, 'Oh, wow. I could say this some day on stage.'

To me, political office should be like jury duty. You should just get a notice in the mail one day and say, 'Aw, sh - , I'm secretary of state next month.

I have American in-laws, and I care about the environment. We don't use disposable diapers, which, of course, creates an environmental problem of our own.

It should be like a salmon taking to open water. I've done so much morning radio that I won't be overwhelmed by it, but it's still going to be a challenge.

Once when Larry the Cable Guy was on Conan's show, Conan O'Brien was so offended by Larry's material, he had to walk away from the desk he was so offended.

George Lopez is always on the verge of hilarity. If he could ever think of something funny to say, if he had a funny thought in his mind, he's ready to go.

In comedy, I hate that cop-out where you say, "Just kidding." I know you're just kidding. Don't insult my intelligence by spelling it out for me that much.

I'm an ardent tennis player. I'm like an overenthusiastic child out there and I've damaged my back. It's not that it's crippling pain, more mental anguish.

Fundamentally, I was a very shy and quiet person growing up, so it was just really difficult getting up on a stage. It was a perverse career choice really.

Irish people are still very prickly about Catholic Church. Despite all the scandals and cover-ups that have rocked the church, you can only push it so far.

It's a new era at Disney. From now on, Snow White and the Seven Dwarfs will be known as Person of No Color and the Seven Vertically Challenged Individuals.

I think poshness is very funny! But I think it's also delightful. There's something wonderful and very innocent about it, particularly with the Edwardians.

I just hate stupid people. They should have to wear signs that say 'I'm Stupid.' That way you wouldn't rely on them, and you wouldn't ask them for nothing.

I have been passed over on some things because people didn't think I was edgy enough. But the people who took those gigs are gone now, and I am still here.

Democrats are lame. The media is lame. And Donald Trump hasn't even played his war card yet. You know, he could start a war and get a lot of support there.

Why can't God just defeat the devil and get rid of evil? It's the same reason the comic book character can't get rid of his nemesis; then there's no story.

Well, I hate to tell youbut if you have a flu shot for more than five years in a row, there's ten times the likelihood that you'll get Alzheimer's disease.

You know, if you're an American and you're born at this time in history especially, you're lucky. We all are. We won the world history Powerball lottery...

To give you an idea how slowly we are leaving Afghanistan, Afghans don't refer to us anymore as 'infidel crusaders.' They refer to us as 'Irish relatives.'

In comedy, falling means laughter. You can take something sacred and make it silly. The more sacred it is, the funnier it is. It has a bigger drop to fall.

My idea of Christmas, whether old-fashioned or modern, is very simple: loving others. Come to think of it, why do we have to wait for Christmas to do that?

I grew up in a mixed religious household. And it was volatile. My dad's atheist, my mom's agnostic. Just constant fighting. There's no God! There might be!

You've got to try and do your best, and the failure is what's funny. But you can't be aware of the failure, you've just got to keep trying to do your best.

I was part of the draft resistance movement in LA where we did demonstrations at the draft centre and burned our cards and made a lot of trouble on campus.

No one has ever said to me 'go home and make a baby.' I have been told several times to go to Planned Parenthood and make the baby go away. Happy Hannukah.

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