To stop short in any research that bids fair to widen the gates of knowledge, to recoil from fear of difficulty or adverse criticism, is to bring reproach on science. There is nothing for the investigator to do but go straight on, 'to explore up and down, inch by inch, with the taper his reason;' to follow the light wherever it may lead, even should it at times resemble a will-o'-the-wisp.

Science as an intellectual exercise enriches our culture, and is in itself ennobling. ... Though to the layman, the world revealed by the chemist may seem more commonplace, it is not so to him. Each new insight into how the atoms in their interactions express themselves in structure and transformations, not only of inanimate matter, but particularly also of living matter, provides a thrill.

The butterfly's attractiveness derives not only from colors and symmetry: deeper motives contribute to it. We would not think them so beautiful if they did not fly, or if they flew straight and briskly like bees, or if they stung, or above all if they did not enact the perturbing mystery of metamorphosis: the latter assumes in our eyes the value of a badly decoded message, a symbol, a sign.

In every section of the entire area where the word science may properly be applied, the limiting factor is a human one. We shall have rapid or slow advance in this direction or in that depending on the number of really first-class men who are engaged in the work in question. ... So in the last analysis, the future of science in this country will be determined by our basic educational policy.

Compare ... the various quantities of the same element contained in the molecule of the free substance and in those of all its different compounds and you will not be able to escape the following law: The different quantities of the same element contained in different molecules are all whole multiples of one and the same quantity, which always being entire, has the right to be called an atom.

An amino acid residue (other than glycine) has no symmetry elements. The general operation of conversion of one residue of a single chain into a second residue equivalent to the first is accordingly a rotation about an axis accompanied by translation along the axis. Hence the only configurations for a chain compatible with our postulate of equivalence of the residues are helical configurations.

The universe is an asymmetrical entity. I am inclined to believe that life as it is manifested to us must be a function of the asymmetry of the universe or of the consequence of this fact. The universe is asymmetrical; for if one placed the entire set of bodies that compose the solar system, each moving in its own way, before a mirror, the image shown would not be superimposable on the reality.

The only weapon we have to oppose the bad effects of technology is technology itself. There is no other. We can't retreat into a nontechnological Eden which never existed...It is only by the rational use of technology to control and guide what technology is doing that we can keep any hopes of a social life more desireable than our own: or in fact of a social life which is not appalling to imagine.

Most of the scientists I have known well have felt - just as deeply as the non-scientists I have known well - that the individual condition of each is tragic. Each of us is alone: sometimes we escape from solitariness, through love or affection or perhaps creative moments, but those triumphs of life are pools of light we make for ourselves while the edge of the road is black: each of us dies alone.

The finest imagination in the world could not have conceived of a better idea than the philosophers' stone to inspire the minds and faculties of men. Without it, chemistry would not be what it is today. In order to discover that no such thing as the philosopher's stone existed, it was necessary to ransack and analyze every substance known on earth. And in precisely this lay its miraculous influence.

And by the influence of heat, light, and electrical powers, there is a constant series of changes; matter assumes new forms, the destruction of one order of beings tends to the conservation of another; solution and consolidation, decay and renovation, are connected; and whilst the parts of the system continue in a state of fluctuation and change, the order and harmony of the whole remain unalterable.

Preconceived ideas are like searchlights which illumine the path of the experimenter and serve him as a guide to interrogate nature. They become a danger only if he transforms them into fixed ideas-this is why I should like to see these profound words inscribed on the threshold of all the temples of science: 'The greatest derangement of the mind is to believe in something because one wishes it to be so.'

Knowledge is like a knife. In the hands of a well-balanced adult it is an instrument for good of inestimable value; but in the hands of a child, an idiot, a criminal, a drunkard or an insane man, it may cause havoc, misery, suffering and crime. Science and religion have this in common, that their noble aims, their power for good, have often, with wrong men, deteriorated into a boomerang to the human race.

Probably our atomic weights merely represent a mean value around which the actual atomic weights of the atoms vary within certain narrow limits... when we say, the atomic weight of, for instance, calcium is 40, we really express the fact that, while the majority of calcium atoms have an actual atomic weight of 40, there are not but a few which are represented by 39 or 41, a less number by 38 or 42, and so on.

We can look at the way of improving the key biochemical processes like photosynthesis itself. A lot of energy is lost to keep the plant cool. So maybe we can think of building plants which are more resistant to heat. Genetically modified plants can be one answer and we can imagine more efficient plants, call them 'energy plants'. And I believe, contrary to what ecologists think, they can still be beautiful plants.

Our schools offer no conception of the scientific process of discovery. They do not encourage creative thought, in fact, they stifle it through too much rigidity in teaching. If we set out to give as little help as possible to originality in science, we could hardly devise a better plan than our education system. Youngsters ought to be told what is unknown about ourselves and our universe as well as what is known.

Geology, perhaps more than any other department of natural philosophy, is a science of contemplation. It requires no experience or complicated apparatus, no minute processes upon the unknown processes of matter. It demands only an enquiring mind and senses alive to the facts almost everywhere presented in nature. And as it may be acquired without much difficulty, so it may be improved without much painful exertion.

The future of humanity is uncertain, even in the most prosperous countries, and the quality of life deteriorates; and yet I believe that what is being discovered about the infinitely large and infinitely small is sufficient to absolve this end of the century and millennium. What a very few are acquiring in knowledge of the physical world will perhaps cause this period not to be judged as a pure return of barbarism.

Somehow, the agenda has been put into the form of talking about a set of transitions from state A, the present, to a state B that's sustainable. The problem is that there is no such state. You have to assume that the transitions are going to continue forever and ever and ever. You have to talk about systems that are continuously dynamic, and that are embedded in environments that themselves are continuously dynamic.

One can, then, conceive the production, by purely mineral means, of all natural hydrocarbons. The intervention of heat, of water, and of alkaline metals - lastly, the tendency of hydrocarbons to unite together to form the more condensed material - suffice to account for the formation of these curious compounds. Moreover, this formation will be continuous because the reactions which started it are renewed incessantly.

Without theory, practice is but routine born of habit. Theory alone can bring forth and develop the spirit of invention. ... [Do not] share the opinion of those narrow minds who disdain everything in science which has not an immediate application. ... A theoretical discovery has but the merit of its existence: it awakens hope, and that is all. But let it be cultivated, let it grow, and you will see what it will become.

Without an acquaintance with chemistry, the statesman must remain a stranger to the true vital interests of the state, to the means of its organic development and improvement; ... The highest economic or material interests of a country, the increased and more profitable production of food for man and animals, ... are most closely linked with the advancement and diffusion of the natural sciences, especially of chemistry.

I felt I was moving among two groups [literary intellectuals and scientists] comparable in intelligence, identical in race, not grossly different in social origin, earning about the same incomes, who had almost ceased to communicate at all, who in intellectual, moral and psychological climate had so little in common that instead of going from Burlington Hom or South Kensington to Chelsea, one might have crossed an ocean.

To me there never has been a higher source of honour or distinction than that connected with advances in science. I have not possessed enough of the eagle in my character to make a direct flight to the loftiest altitudes in the social world; and I certainly never endeavored to reach those heights by using the creeping powers of the reptile, who in ascending, generally chooses the dirtiest path, because it is the easiest.

You have to have a lot of ideas. First, if you want to make discoveries, it's a good thing to have good ideas. And second, you have to have a sort of sixth sense-the result of judgment and experience-which ideas are worth following up. I seem to have the first thing, a lot of ideas, and I also seem to have good judgment as to which are the bad ideas that I should just ignore, and the good ones, that I'd better follow up.

When you believe you have found an important scientific fact, and are feverishly curious to publish it, constrain yourself for days, weeks, years sometimes, fight yourself, try and ruin your own experiments, and only proclaim your discovery after having exhausted all contrary hypotheses. But when, after so many efforts you have at last arrived at a certainty, your joy is one of the greatest which can be felt by a human soul.

The field of scientific abstraction encompasses independent kingdoms of ideas and of experiments and within these, rulers whose fame outlasts the centuries. But they are not the only kings in science. He also is a king who guides the spirit of his contemporaries by knowledge and creative work, by teaching and research in the field of applied science, and who conquers for science provinces which have only been raided by craftsmen.

My only supporter and comrade-in-arms was Georg Helm, who had endeavored to formulate an energetic conception of science before me and had presented his results in a treatise [Die Lehre von der Energie] exhibiting great independence of thought. But we were separated by his aversion to a realistic conception of energy. Consequently, each of us considered the other only a half ally, toward whom an attitude of caution was necessary.

From this time everything was copulated. Acetic, formic, butyric, margaric, &c., acids, alkaloids, ethers, amides, anilides, all became copulated bodies. So that to make acetanilide, for example, they no longer employed acetic acid and aniline, but they re-copulated a copulated oxalic acid with a copulated ammonia. I am inventing nothing-altering nothing. Is it my fault if, when writing history, I appear to be composing a romance?

Think that you are part of a big construction called science and you are not just a chemist but you are scientist. Be modest but proud. Modest because you know you will not be able to solve other problems because your life is too short. But be proud because you are contributing to it. Some people will bring a small stone to the building and some people will bring a big one but nevertheless no one can take that stone away from you.

Public education is a great instrument of social change. Through it, if we so desire, we can make our country more nearly a democracy without classes. To do so will require the efforts of us all-teachers, administrators, taxpayers and statesmen. Education is a social process, perhaps the most important process in determining the future of our country; it should command a far larger portion of our national income than it does today.

I, as a responsible adult human being, will never concede the power to anyone to regulate my choice of what I put into my body, or where I go with my mind. From the skin inwards is my jurisdiction, is it not? I choose what may or may not cross that border. Here I am the Customs Agent. I am the Coast guard. I am the sole legal and spiritual government of this territory, and only the laws I choose to enact within myself are applicable

The impossibility of separating the nomenclature of a science from the science itself, is owing to this, that every branch of physical science must consist of three things; the series of facts which are the objects of the science, the ideas which represent these facts, and the words by which these ideas are expressed. Like three impressions of the same seal, the word ought to produce the idea, and the idea to be a picture of the fact.

Will fluorine ever have practical applications? It is very difficult to answer this question. I may, however, say in all sincerity that I gave this subject little thought when I undertook my researches, and I believe that all the chemists whose attempts preceded mine gave it no more consideration. A scientific research is a search after truth, and it is only after discovery that the question of applicability can be usefully considered.

After all, we scientific workers ... like women, are the victims of fashion: at one time we wear dissociated ions, at another electrons; and we are always loth to don rational clothing; some fixed belief we must have manufactured for us: we are high or low church, of this or that degree of nonconformity, according to the school in which we are brought up-but the agnostic is always rare of us and of late years the critic has been taboo.

In order for the wheel to turn, for life to be lived, impurities are needed, and the impurities of impurities in the soil, too, as is known, if it is to be fertile. Dissension, diversity, the grain of salt and mustard are needed: Fascism does not want them, forbids them, and that's why you're not a Fascist; it wants everybody to be the same, and you are not. But immaculate virtue does not exist either, or if it exists it is detestable.

We can trace back our existence almost to a point. Former time presents us with trains of thoughts gradually diminishing to nothing. But our ideas of futurity are perpetually expanding. Our desires and our hopes, even when modified by our fears, seem to grasp at immensity. This alone would be sufficient to prove the progressiveness of our nature, and that this little earth is but a point from which we start toward a perfection of being.

I propose to provide proof... that just as always an alcoholic ferment, the yeast of beer, is found where sugar is converted into alcohol and carbonic acid, so always a special ferment, a lactic yeast, is found where sugar is transformed into lactic acid. And, furthermore, when any plastic nitrogenated substance is able to transform sugar into that acid, the reason is that it is a suitable nutrient for the growth of the [lactic] ferment.

There is a beauty in discovery. There is mathematics in music, a kinship of science and poetry in the description of nature, and exquisite form in a molecule. Attempts to place different disciplines in different camps are revealed as artificial in the face of the unity of knowledge. All literate men are sustained by the philosopher, the historian, the political analyst, the economist, the scientist, the poet, the artisan and the musician.

My present and most fixed opinion regarding the nature of alcoholic fermentation is this: The chemical act of fermentation is essentially a phenomenon correlative with a vital act, beginning and ending with the latter. I believe that there is never any alcoholic fermentation without their being simultaneously the organization, development, multiplication of the globules, or the pursued, continued life of globules which are already formed.

[When questioned on his longevity] First of all, I selected my ancestors very wisely. ... They were long-lived, healthy people. Then, as a chemist, I know how to eat, how to exercise, keep my blood circulating. ... I don't worry. I don't get angry at people. I don't worry about things I can't help. I do what I can to make the world a better place to live, but I don't complain if things aren't right. As a scientist I take the world as I find it.

Since the discovery of oxygen the civilised world has undergone a revolution in manners and customs. The knowledge of the composition of the atmosphere, of the solid crust of the earth, of water, and of their influence upon the life of plants and animals, was linked to that discovery. The successful pursuit of innumerable trades and manufactures, the profitable separation of metals from their ores, also stand in the closest connection therewith.

The McCarthy period came along...and many of the other scientists who had been working on these same lines gave up. Probably saying "Why should I sacrifice myself? I am a scientist, I am supposed to be working on scientific things, so I don't need to put myself at risk by talking about these possibilities." And I have said that perhaps I'm just stubborn... I have said "I don't like anybody to tell me what to do or to think, except Mrs. Pauling."

I will now direct the attention of scientists to a previously unnoticed cause which brings about the metamorphosis and decomposition phenomena which are usually called decay, putrefaction, rotting, fermentation and moldering. This cause is the ability possessed by a body engaged in decomposition or combination, i.e. in chemical action, to give rise in a body in contact with it the same ability to undergo the same change which it experiences itself.

The nucleic acids, as constituents of living organisms, are comparable In importance to proteins. There is evidence that they are Involved In the processes of cell division and growth, that they participate In the transmission of hereditary characters, and that they are important constituents of viruses. An understanding of the molecular structure of the nucleic acids should be of value In the effort to understand the fundamental phenomena of life.

Even in this place one can survive, and therefore one must want to survive, to tell the story, to bear witness; and that to survive we must force ourselves to save at least the skeleton, the scaffolding, the form of civilization. We are slaves, deprived of every right, exposed to every insult, condemned to certain death, but we still possess one power, and we must defend it with all our strength for it is the last — the power to refuse our consent.

The experiments made on the mutual electrical relations of bodies have taught us that they can be divided into two classes: electropositive and electronegative. The simple bodies which belong to the first class, as well as their oxides, always take up positive electricity when they meet simple bodies or oxides belonging to the second class; and the oxides of the first class always behave with the oxides of the other like salifiable bases with acids.

I have to deplore the systematic manner in which the literature of Europe has continued to put out of sight our obligations to the Muhammadans. Surely they cannot be much longer hidden. Injustice founded on religious rancour and national conceit cannot be perpetuated forever. The Arab has left his intellectual impress on Europe. He has indelibly written it on the heavens as any one may see who reads the names of the stars on a common celestial globe.

Our immediate interests are after all of but small moment. It is what we do for the future, what we add to the sum of man's knowledge, that counts most. As someone has said, 'The individual withers and the world is more and more.' Man dies at 70, 80, or 90, or at some earlier age, but through his power of physical reproduction, and with the means that he has to transmit the results of effort to those who come after him, he may be said to be immortal.

As mineralogy constitutes a part of chemistry, it is clear that this arrangement [of minerals] must derive its principles from chemistry. The most perfect mode of arrangement would certainly be to allow bodies to follow each other according to the order of their electro-chemical properties, from the most electro-negative, oxygen, to the most electro-positive, potassium; and to place every compound body according to its most electro-positive ingredient.

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