Quotes of All Topics . Occasions . Authors
It has been recognized that hydrogen bonds restrain protein molecules to their native configurations, and I believe that as the methods of structural chemistry are further applied to physiological problems it will be found that the significance of the hydrogen bond for physiology is greater than that of any other single structural feature.
Because we were orbiting the earth faster than earth spins on its axis, we went around the earth 16 times a day, an earth day, which meant 16 periods of lightness and 16 periods of darkness in 24 hours. Every so often you'd look towards the earth, and often you could see lightness and darkness together, and dawn and sunset were spectacular.
I recognize that many physicists are smarter than I am-most of them theoretical physicists. A lot of smart people have gone into theoretical physics, therefore the field is extremely competitive. I console myself with the thought that although they may be smarter and may be deeper thinkers than I am, I have broader interests than they have.
The phenomena in these exhausted tubes reveal to physical science a new world-a world where matter may exist in a fourth state, where the corpuscular theory of light may be true, and where light does not always move in straight lines, but where we can never enter, and with which we must be content to observe and experiment from the outside.
..The truly fraudulent claims must be discarded. But novel methods of therapy should not be rejected because they are novel, or because they run counter to some generally accepted belief ("which may just be biased"), or because we do not understand the mechanism of the proposed treatment, or because it has come from an unconventional source.
You can be an idiot and survive because you just go to McDonalds for your food, and you go to work and do some sort of inane job, which is nobody taking any responsibility - it's always up the line - and then you watch the Super Bowl, and that's it. But in the old days, you really had to know how your world works. You don't need that anymore.
I knew, however, that it would cost ten times what I had available in order to build a molecular beam machine. I decided to follow a byway, rather than the highway. It is a procedure I have subsequently recommended to beginning scientists in this country, where research strategy is best modelled on that used by Wolfe at the Plains of Abraham.
The chemists work with inaccurate and poor measuring services, but they employ very good materials. The physicists, on the other hand, use excellent methods and accurate instruments, but they apply these to very inferior materials. The physical chemists combine both these characteristics in that they apply imprecise methods to impure materials.
It is a remarkable fact that the second law of thermodynamics has played in the history of science a fundamental role far beyond its original scope. Suffice it to mention Boltzmann's work on kinetic theory, Planck's discovery of quantum theory or Einstein's theory of spontaneous emission, which were all based on the second law of thermodynamics.
Nature is beautiful, and you are in her bosom. That voice of comfort which speaks in the breezes of morning, may visit your mind, that the delightful influences which the green leaves, the blue sky, the moonbeams and clouds of the evening diffuse over the universe, may in their powers of soul-healing, visit your day visions, is my desire and hope.
The pace at which science has progressed has been too fast for human behaviour to adapt to it. As I said we are still apes. A part of our brain is still a paleo-brain and many of the reactions come from our fight or flight instinct. As long as this part of the brain can take over control the rational part of the brain (we will face these problems).
But weightier still are the contentment which comes from work well done, the sense of the value of science for its own sake, insatiable curiosity, and, above all, the pleasure of masterly performance and of the chase. These are the effective forces which move the scientist. The first condition for the progress of science is to bring them into play.
Virulence appears in a new light which cannot but be alarming to humanity; unless nature, in her evolution down the ages (an evolution which, as we now know, has been going on for millions, nay, hundreds of millions of years), has finally exhausted all the possibilities of producing virulent or contagious diseases - which does not seem very likely.
But if the two countries or governments are at war, the men of science are not. That would, indeed be a civil war of the worst description: we should rather, through the instrumentality of the men of science soften the asperities of national hostility. Davy's remarks to Thomas Poole on accepting Napoleon's prize for the best experiment on Galvanism.
Heat may be considered, either in respect of its quantity, or of its intensity. Thus two lbs. of water, equally heated, must contain double the quantity that one of them does, though the thermometer applied to them separately, or together, stands at precisely the same point, because it requires double the time to heat two lbs. as it does to heat one.
We must have research for peace ... It would embrace the outstanding problems of morality. The time has come for man's intellect, his scientific method, to win over the immoral brutality and irrationality of war and militarism ... Now we are forced to eliminate from the world forever this vestige of prehistoric barbarism, this curse to the human race.
Synthesis..., perhaps in greater measure than activities in any other area of organic chemistry, provides a measure of the condition and power of science. For synthetic undertakings are seldom if ever undertaken by chance, nor will the most painstaking, or inspired, purely observational activities suffice. Synthesis must always be carried out by plan.
I build molecules for a living. I can't begin to tell you how difficult that job is. I stand in awe of God because of what he has done through his creation. My faith has been increased through my research. Only a rookie who knows nothing about science would say science takes away from faith. If you really study science, it will bring you closer to God.
...It would be possible to make much more progress than has been made if the NCI knew its job better, knew how to make discoveries...The NCI really does not know how to make discoveries....So long as the NCI is not willing to follow up ideas that seem good to people who have had experience making discoveries, the work of the NCI is going to be pedestrian.
I happen to be a kind of monkey. I have a monkeylike curiosity that makes me want to feel, smell, and taste things which arouse my curiosity, then to take them apart. It was born in me. Not everybody is like that, but a scientific researchist should be. Any fool can show me an experiment is useless. I want a man who will try it and get something out of it.
Great Power, capable of everything and only temporarily handicapped by economic difficulties. We are not a great power and never will be again. We are a great nation, but if we continue to behave like a Great Power we shall soon cease to be a great nation. Let us take warning from the fate of the Great Powers of the past and not burst ourselves with pride .
Sooner or later in life everyone discovers that perfect happiness is unrealizable, but there are few who pause to consider the antithesis: that perfect unhappiness is equally unattainable. The obstacles preventing the realization of both these extreme states are of the same nature: they derive from our human condition which is opposed to everything infinite.
Therefore, a grotesque account of a period some thousands of years ago is taken seriously though it be built by piling special assumptions on special assumptions, ad hoc hypothesis [invented for a purpose] on ad hoc hypothesis, and tearing apart the fabric of science whenever it appears convenient. The result is a fantasia which is neither history nor science.
It was obvious-to me at any rate-that the answer was to why an enzyme is able to speed up a chemical reaction by as much as 10 million times. It had to do this by lowering the energy of activation-the energy of forming the activated complex. It could do this by forming strong bonds with the activated complex, but only weak bonds with the reactants or products.
If the structure that serves as a template (the gene or virus molecule) consists of, say, two parts, which are themselves complementary In structure, then each of these parts can serve as the mould for the production of a replica of the other part, and the complex of two complementary parts thus can serve as the mould for the production of duplicates of itself.
Ostwald was a great protagonist and an inspiring teacher. He had the gift of saying the right thing in the right way. When we consider the development of chemistry as a whole, Ostwald's name like Abou ben Adhem's leads all the rest ... Ostwald was absolutely the right man in the right place. He was loved and followed by more people than any chemist of our time.
...Nature-the word that stands for the baffling mysteries of the Universe. Steadily, unflinchingly, we strive to pierce the inmost heart of Nature, from what she is to reconstruct what she has been, and to prophesy what she yet shall be. Veil after veil we have lifted, and her face grows more beautiful, august, and wonderful, with every barrier that is withdrawn.
Cuvier had even in his address & manner the character of a superior Man, much general power & eloquence in conversation & great variety of information on scientific as well as popular subjects. I should say of him that he is the most distinguished man of talents I have ever known on the continent: but I doubt if He be entitled to the appellation of a Man of Genius.
We have a word game in English called "Twenty questions." To play Twenty Questions, one player imagines some object, and the other players must guess what it is by asking questions that can be answered with a "yes" or a "no." I imagine every language has a similar game, and, for those of us who speak the language of science, the game is called The Scientific Method.
As a result of continuous work with these highly toxic substances, our minds were so numbed that we no longer had any scruples about the whole thing. Anyway, our enemies had by now adopted our methods and as they became increasingly successful in this mode of warfare we were no longer exclusively the aggressors, but found ourselves more and more at the receiving end.
[About the demand of the Board of Regents of the University of California that professors sign non-Communist loyalty oaths or lose their jobs within 65 days.] No conceivable damage to the university at the hands of hypothetical Communists among us could possibly have equaled the damage resulting from the unrest, ill-will and suspicion engendered by this series of events.
I take it that a monograph of this sort belongs to the ephemera literature of science. The studied care which is warranted in the treatment of the more slowly moving branches of science would be out of place here. Rather with the pen of a journalist we must attempt to record a momentary phase of current thought, which may at any instant change with kaleidoscopic abruptness.
In my opinion the separation of the c- and ac-stars is the most important advancement in stellar classification since the trials by Vogel and Secchi ... To neglect the c-properties in classifying stellar spectra, I think, is nearly the same thing as if a zoologist, who has detected the deciding differences between a whale and a fish, would continue classifying them together.
That henceforth the absurd game of chemical noughts and crosses be tabu within the Society's precincts and that, following the practice of the Press in ending a correspondence, it be an instruction to the officers to give notice "That no further contributions to the mysteries of Polarity will be received, considered or printed by the Society." His challenge was not accepted.
I suppose there was never yet a woman who had not somewhere set up on a pedestal in her brain an ideal of manhood. ... He never is finished till the brain of his creator ceases to work, till she has added her last touch to him, and has laid down the burden of life and gone elsewhere, perhaps to some happy land where ideals are more frequently realised than ever happens here.
Liebig taught the world two great lessons. The first was that in order to teach chemistry it was necessary that students should be taken into a laboratory. The second lesson was that he who is to apply scientific thought and method to industrial problems must have a thorough knowledge of the sciences. The world learned the first lesson more readily than it learned the second.
Anyone who thinks we can continue to have world wars but make them nice polite affairs by outlawing this weapon or that should meditate upon the outlawing of the cross-bow by Papal authority. Setting up the machinery for international law and order must surely precede disarmament. The Wild West did not abandon its shooting irons till after sheriffs and courts were established.
[Fritz Haber's] greatness lies in his scientific ideas and in the depth of his searching. The thought, the plan, and the process are more important to him than the completion. The creative process gives him more pleasure than the yield, the finished piece. Success is immaterial. "Doing it was wonderful." His work is nearly always uneconomical, with the wastefulness of the rich.
Briefly, in the act of composition, as an instrument there intervenes and is most potent, fire, flaming, fervid, hot; but in the very substance of the compound there intervenes, as an ingredient, as it is commonly called, as a material principle and as a constituent of the whole compound the material and principle of fire, not fire itself. This I was the first to call phlogiston.
Reagents are regarded as acting by virtue of a constitutional affinity either for electrons or for nuclei... the terms electrophilic (electron-seeking) and nucleophilic (nucleus-seeking) are suggested... and the organic molecule, in the activation necessary for reaction, is therefore required to develop at the seat of attack either a high or low electron density as the case may be.
They sensed that what had happened around them and in their presence, and in them, was irrevocable. Never again could it be cleansed; it would prove that man, the human species - we, in short - had the potential to construct an enormity of pain, and that pain is the only force created from nothing, without cost and without effort. It is enough not to see, not to listen, not to act.
If I am allowed to give a metaphorical allusion to the future state of the blessed, I should imagine it by the orange-grove in that sheltered glen on which the sun is now beginning to shine, and of which the trees are at the same time, loaded with sweet golden fruit and balmy silver flowers. Such objects may well portray a state in which hope and fruition become one eternal feeling.
The whole language of nature informs us, that in animated beings there is something above our powers of investigation; something which employs, combines, and arranges the gross elements of matter - a spark of celestial fire, by which life is kindled and preserved, and which, if even the instruments it employs are indestructible in their essence, must itself, of necessity, be immortal.
To accuse another of having weak kidneys, lungs, or heart, is not a crime; on the contrary, saying he has a weak brain is a crime. To be considered stupid and to be told so is more painful than being called gluttonous, mendacious, violent, lascivious, lazy, cowardly: every weakness, every vice, has found its defenders, its rhetoric, its ennoblement and exaltation, but stupidity hasn't.
Alfred Nobel - pitiable half-creature, should have been stifled by humane doctor when he made his entry yelling into life. Greatest merits: Keeps his nails clean and is never a burden to anyone. Greatest fault: Lacks family, cheerful spirits, and strong stomach. Greatest and only petition: Not to be buried alive. Greatest sin: Does not worship Mammon. Important events in his life: None.
Great problems are now being handled, keeping every thinking man in suspense; the unity or multiplicity of human races; the creation of man 1,000 years or 1,000 centuries ago; the fixity of species, or the slow and progressive transformation of one species into another; the eternity of matter; the idea of a God unnecessary: such are some of the questions that humanity discusses nowadays.
In early life I had felt a strong desire to devote myself to the experimental study of nature; and, happening to see a glass containing some camphor, portions of which had been caused to condense in very beautiful crystals on the illuminated side, I was induced to read everything I could obtain respecting the chemical and mechanical influences of light, adhesion, and capillary attraction.
[Pitchblende] consists of a peculiar, distinct, metallic substance. Therefore its former denominations, Pechblende, pitch-iron-ore, &c. are no longer applicable, and must be supplied by another more appropriate name. I have chosen that of Uranium, as a kind of memorial, that the chemical discovery of this new metal happened in the period of astronomical discovery of the new planet Uranus.
No scientist or student of science, need ever read an original work of the past. As a general rule, he does not think of doing so. Rutherford was one of the greatest experimental physicists, but no nuclear scientist today would study his researches of fifty years ago. Their substance has all been infused into the common agreement, the textbooks, the contemporary papers, the living present.
To comprehend a man's life, it is necessary to know not merely what he does but also what he purposely leaves undone. There is a limit to the work that can be got out of a human body or a human brain, and he is a wise man who wastes no energy on pursuits for which he is not fitted; and he is till wiser who, from among the things that he can do well, chooses and resolutely follows the best.