I looked for it [heavy hydrogen, deuterium] because I thought it should exist. I didn't know it would have industrial applications or be the basic for the most powerful weapon ever known [the nuclear bomb] ... I thought maybe my discovery might have the practical value of, say, neon in neon signs.

To demonstrate experimentally that a microscopic organism actually is the cause of a disease and the agent of contagion, I know no other way, in the present state of Science, than to subject the microbe (the new and happy term introduced by M. Sédillot) to the method of cultivation out of the body.

A detective with his murder mystery, a chemist seeking the structure of a new compound, use little of the formal and logical modes of reasoning. Through a series of intuitions, surmises, fancies, they stumble upon the right explanation, and have a knack of seizing it when it once comes within reach.

The art of drawing conclusions from experiments and observations consists in evaluating probabilities and in estimating whether they are sufficiently great or numerous enough to constitute proofs. This kind of calculation is more complicated and more difficult than it is commonly thought to be. . . .

Only about seventy years ago was chemistry, like a grain of seed from a ripe fruit, separated from the other physical sciences. With Black, Cavendish and Priestley, its new era began. Medicine, pharmacy, and the useful arts, had prepared the soil upon which this seed was to germinate and to flourish.

Nothing tends so much to the advancement of knowledge as the application of a new instrument. The native intellectual powers of men in different times are not so much the causes of the different success of their labours, as the peculiar nature of the means and artificial resources in their possession.

It is relatively unusual that a physical scientist is truly an atheist. Why is this true? Some point to the anthropic constraints, the remarkable fine tuning of the universe. For example, Freeman Dyson, a Princeton faculty member, has said, 'Nature has been kinder to us that we had any right to expect.'

The bond between a man and his profession is similar to that which ties him to his country; it is just as complex, often ambivalent, and in general it is understood completely only when it is broken: by exile or emigration in the case of one's country, by retirement in the case of a trade or profession.

The stumbling way in which even the ablest of the scientists in every generation have had to fight through thickets of erroneous observations, misleading generalizations, inadequate formulation, and unconscious prejudice is rarely appreciated by those who obtain their scientific knowledge from textbooks.

I was born on September 30, 1939, in Rosheim, a small medieval city of Alsace in France. My father, Pierre Lehn, then a baker, was very interested in music, played the piano and the organ, and became, later, having given up the bakery, the organist of the city. My mother Marie kept the house and the shop.

The person who observes a clock, sees in it not only the pendulum swinging to and fro, and the dial-plate, and the hands moving, for a child can see all this; but he sees also the parts of the clock, and in what connexion the suspended weight stands to the wheel-work, and the pendulum to the moving hands.

One will only be free when one plays and one's society will become a piece of art". - Herbert Marcuse "Play is a phenomenon of nature and has directed the course of the world from the beginning of time: the formation of matter, its organization into living structures as well as the social behavior of man.

There are, in fact, very few organic zinc compounds; only the first members of the series, which correspond to the simplest organic radicals, can be prepared without too much difficulty, but they have the disadvantage of being spontaneously inflammable in air and are consequently very dangerous to handle.

For the first time I saw a medley of haphazard facts fall into line and order. All the jumbles and recipes and hotchpotch of the inorganic chemistry of my boyhood seemed to fit into the scheme before my eyes-as though one were standing beside a jungle and it suddenly transformed itself into a Dutch garden.

At no point do I ever remember taking religion very seriously or even feeling that the biblical stories were any different from fairy stories. Certainly, none of it made any sense. By comparison, the world in which I lived, though I might not always understand it in all aspects, always made a lot of sense.

During launch, the outside of the rocket is covered in a protective fairing, so we couldn't see outside, but as soon as that was jettisoned, my first view of the earth was over the Pacific Ocean, which was this wonderful deep blue, with clouds just over the top, and sunlight streaming in through the window.

In 1998, I set up and directed a research group at the Nanotechnology Institute newly created in the Research Center of Karlsruhe. This allowed to offer to former post-doctoral coworkers the opportunity to develop and to progressively set up independent research activities in nanoscience and nanotechnology.

Heisenberg has discussed the coupled double harmonic oscillator, and has shown that the ordinary rules of quantization lead to two non-combining sets of states in one of which the electrons are in phase and out of phase. The energy of the system is successively transferred from one to the other - resonance!

As ideas are preserved and communicated by means of words, it necessarily follows that we cannot improve the language of any science, without at the same time improving the science itself; neither can we, on the other hand, improve a science without improving the language or nomenclature which belongs to it.

Since it is the very substance of the animal, it is the blood which transports the fuel.If the animal did not habitually replace, through nourishing themselves,what they losethrough respiration, the lamp would very soon run out of oil and the animal would perish, just as the lamp goes out when it lacks fuel.

The well-mannered man never puts out his hand in greeting until a lady extends hers. This is a test of good breeding that is constantly applied. ... The first move in the direction of cordiality must come from the lady, the whole code of behaviour being based on the assumption that she is the social superior.

Mr. Dalton's permanent reputation will rest upon his having discovered a simple principle, universally applicable to the facts of chemistry - in fixing the proportions in which bodies combine, and thus laying the foundation for future labors... his merits in this respect resemble those of Kepler in astronomy.

This is the most immediate fruit of exile, of uprooting: the prevalence of the unreal over the real. Everyone dreamed past and future dreams, of slavery and redemption, of improbable paradises, of equally mythical and improbable enemies; cosmic enemies, perverse and subtle, who pervade everything like the air.

Ionizing radiation may well be the most important single cause of cancer, birth defects, and genetic disorders... The stakes for human health are very, very high in radiation matters. It is essential that people take no chance that conflict-of-interest is producing radiation databases which...cannot be trusted.

Every chemical substance, whether natural or artificial, falls into one of two major categories, according to the spatial characteristic of its form. The distinction is between those substances that have a plane of symmetry and those that do not. The former belong to the mineral, the latter to the living world.

In bitter almond oil, like in a great number of other substances that previously had been counted among the 'aromatic compounds' on behalf of their strong smell, a derivative of benzene is present. The special properties of benzene and its derivatives are caused by the typical arrangement of their carbon atoms.

All of us who study the origin of life find that the more we look into it, the more we feel it is too complex to have evolved anywhere. We all believe as an article of faith that life evolved from dead matter on this planet. It is just that life's complexity is so great, it is hard for us to imagine that it did.

Biological energy comes from the sun. Light energy harvested by photosynthesis in chloroplasts and phototropic bacteria becomes stored in carbohydrates and fats. This stored energy can be released by oxidative metabolism in the form of adenosine triphosphate (ATP) and used as fuel for other biological processes.

The progression of physical science is much more connected with your prosperity than is usually imagined. You owe to experimental philosophy some of the most important and peculiar of your advantages. It is not by foreign conquests chiefly that you are become great, but by a conquest of nature in your own country.

To demand that a person pee in a cup whenever you wish him to, without a documented reason to suspect that he has been using an illegal drug, is intolerable in our republic. You are saying to him, "I wonder if you are not behaving in a way that I approve of. Convince me that you indeed are. Outrageous. Intolerable.

Science is based solely on doubt-based, disinterested examination of the natural and physical world. It is entirely independent of personal belief. There is a very important, fundamental concomitant - that is to accept absolutely nothing whatsoever, for which there is no evidence, as having any fundamental validity.

It has been possible to trace historically back to a very early age the taxes which were imposed on medicines, spices and similar substances in German towns. Thus, for instance, one finds that in the year 1500, thirteen, in 1540, thirty-eight, and in 1708, already one hundred and twenty vegetable oils are mentioned.

Science is a dynamic undertaking directed to lowering the degree of the empiricism involved in solving problems; or, if you prefer, science is a process of fabricating a web of interconnected concepts and conceptual schemes arising from experiments and observations and fruitful of further experiments and observations.

I have seen many phases of life; I have moved in imperial circles, I have been a Minister of State; but if I had to live my life again, I would always remain in my laboratory, for the greatest joy of my life has been to accomplish original scientific work, and, next to that, to lecture to a set of intelligent students.

The discipline, nonetheless, is exacting: everything that can be observed should be observed, even if it is only recalled as the bland background from which the intriguing bits pop out like Venus in the evening sky. The goal is always finding something new, hopefully unimagined and, better still, hitherto unimaginable.

[At DuPont,] I was very fortunate that I worked under men who were very much interested in making discoveries and inventions. They were very much interested in what they were doing, and they left me alone. And I was able to experiment on my own, and I found this very stimulating. It appealed to the creative person in me.

Which was first, Matter or Force? If we think on this question, we shall find that we are unable to conceive of matter without force, or force without matter. When God created the elements of which the earth is composed, He created certain wondrous forces, which are set free and become evident when matter acts on matter.

There is a wealth of information built into us ... tucked away in the genetic material in every one of our cells ... without some means of access, there is no way even to begin to guess at the extent and quality of what is there. The psychedelic drugs allow exploration of this interior world, and insights into its nature.

How he could be a good user of LSD," I asked, "And know about the spiritual dimension - all that sort of thing - and still be a crook? I don't understand." "Then it's time you did. Psychedelic drugs don't change you - they don't change you character - unless you want to be changed. They enable change; they can't impose it.

We must be listened to: above and beyond our personal experience, we have collectively witnessed a fundamental unexpected event, fundamental precisely because unexpected, not foreseen by anyone. It happened, therefore it can happen again: this is the core of what we have to say. It can happen, and it can happen everywhere.

If everything in chemistry is explained in a satisfactory manner without the help of phlogiston, it is by that reason alone infinitely probable that the principle does not exist; that it is a hypothetical body, a gratuitous supposition; indeed, it is in the principles of good logic, not to multiply bodies without necessity.

No, there is now no circumstance known in which it can be affirmed that microscopic beings came into the world without germs, without parents similar to themselves. Those who affirm it have been duped by illusions, by ill-conducted experiments, spoilt by errors that they either did not perceive or did not know how to avoid.

By the end of the millennium, despite the continuing excitement of the field, almost thirty years of a detour from chemistry to medical imaging began to pall, and I changed my focus to a field of chemical research, just in time for my past to catch up with me in the form of a Nobel Prize. All detours should be so productive!

I have learnt that all our theories are not Truth itself, but resting places or stages on the way to the conquest of Truth, and that we must be contented to have obtained for the strivers after Truth such a resting place which, if it is on a mountain, permits us to view the provinces already won and those still to be conquered.

Most of my scientific work has been basic research. There were no immediate uses for my discoveries, but today the radioisotopes are the workhorses of nuclear medicine, an isotope of plutonium is a major energy source in the space program, and the element americium is critical to the smoke detectors in every house in the country.

A great deal of the universe does not need any explanation. Elephants, for instance. Once molecules have learnt to compete and to create other molecules in their own image, elephants, and things resembling elephants, will in due course be found roaming around the countryside ... Some of the things resembling elephants will be men.

We should scarcely be excused in concluding this essay without calling the reader's attention to the beneficent and wise laws established by the author of nature to provide for the various exigencies of the sublunary creation, and to make the several parts dependent upon each other, so as to form one well-regulated system or whole.

We think only through the medium of words. Languages are true analytical methods. Algebra, which is adapted to its purpose in every species of expression, in the most simple, most exact, and best manner possible, is at the same time a language and an analytical method. The art of reasoning is nothing more than a language well arranged.

The main issue [of the Scientific Revolution] is that the people in the industrialised countries are getting richer, and those in the non-industrialised countries are at best standing still: so the gap between the industrialised countries and the rest is widening every day. On the world scale this is the gap between the rich and the poor.

Each honest calling, each walk of life, has its own elite, its own aristocracy based on excellence of performance. . . . There will always be the false snobbery which tries to place one vocation above another. You will become a member of the aristocracy in the American sense only if your accomplishments and integrity earn this appellation.

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