I do think comedy needs to be a living thing, but I think without a great script and fully realized characters, you cannot keep it living. Otherwise it just becomes long and rambling indulgent.

Hollywood wants to make women so perfect. Perfect hair. Perfect job. Perfect manners... I know some of the most beautiful women, and they are so weird. That's what makes them funny and captivating.

I loved the playfulness of fashion. I think maybe that's why I became an actress. You put on one outfit and feel one way, and another one will make you feel another way. Clothes are a wonderful tool.

I'm a bit obsessed with women that are so incredibly solid in their shoes that they don't care what other people think of them. I just think there's something so interesting about that kind of confidence.

I wore white kabuki makeup, had blue-black hair. At one point, I shaved an inch and a half around my hairline and continued the white makeup up so it made my head look slightly deformed. I thought it was hilarious.

Everybody's a train wreck in their own very special way. But there's something wildly freeing about someone who's unapologetic, who knows they're a wreck and doesn't even try to hide it, just bulldozes through life.

I lived on a farm in Illinois, and we didn't have a lot of money. But I lived vicariously through magazines. I was obsessed with Jean Paul Gaultier. I still have the scrapbooks, and I've kept all my designs and sketches.

I think when you can actually do what you love to do, if it's a little play somewhere, if it's a photo, if it's anything- if you can somehow do what you want and do a really good job at it, I think that's pretty successful.

You can't just play crazy. It makes you push yourself to stay in the realm of reality. And when you do that, it's a lot funnier. That's my favorite, when you think it's a real strange person and not just someone being wacky.

I'm very boring. But I'm a bit obsessed with women that are so incredibly solid in their shoes that they don't care what other people think of them. I just think there's something so interesting about that kind of confidence.

I see teenagers or people who are 21 and think, 'I was an idiot at that age.' I was running around New York like a crazy woman. Thank God I only had three and a half cents to my name. I was too immature to handle success then.

I've never felt like I needed to change. I've always thought, 'If you want somebody different, pick somebody else.' But sure, criticism can sometimes still get to me. Some things are so malicious, they knock the wind out of you.

I do think comedy needs to be a living thing, but I think without a great script and fully realized characters, you cannot keep it living. Otherwise, it just becomes long and rambling, indulgent. So I think you need both, frankly.

In my 20s, I used to cry about why I wasn't thinner or prettier, but I want to add that I also used to cry about things like, 'I wish my hair would grow faster. I wish I had different shoes...' I was an idiot... It's a decade of tears.

I think if anyone tells you the odds are slim, just keep walking. Just do whatever the hell you want to do, because they don't know what they're talking about. When you love something, and you work really really hard at it, you can do it.

I will embarrass my kids to their core. I will threaten to show up in hot pants and a tube top. Their dad will drive me. And he'll let me and my friend Lisa get pretty drunk in the backseat, and we will come into that party and just rip it up.

When I went to college, I did clothing and textiles. It really wasn't until I moved to New York, my second night in, I did stand-up. I took a wild left turn, and instead of going back and finishing school at FIT, I started doing stand-up and acting.

I felt really bad for someone who is swimming in so much hate. I just thought, that's someone who's in a really bad spot, and I am in such a happy spot. I laugh my head off every day with my husband and my kids who are mooning me and singing me songs.

I've grown to love L.A., but it's the most socially awkward place. All these people have come there not to be something but to pretend to be someone trying to be someone. Even in line for coffee, you're standing with someone who's trying to be so interesting.

I didn't really know how to write jokes, so I just told weird, long stories about being tall and beautiful and wealthy in New York. I'd tell them very seriously, but I kind of looked like a drag queen at the time with big wigs and crazy 12-inch platform heels.

When I was 22, I met with some janky manager, and she told me, 'You're never going to work at this weight.' I think I was a size 6 at the time. There is just this weird thing about how we perceive women in this country. I would love to be a part of breaking that down.

The letters I really love are from young actresses who were worried they had to fit a certain look. They say I've opened it up. And I don't just mean plus-size girls. You can push things now. With all the great performances in 'Bridesmaids', it changed how people see funny women.

I've been every size in the world. Parts of my 20s, I was in great shape, but I didn't appreciate it. If I was a 6 or an 8, I thought, "Why aren't I a 2 or a 4?" Now I feel like I have two great kids and the dreamiest husband on the planet, and everything else is just a work in progress.

I believe it matters how you treat people. I believe in Heaven. I don't believe that this is it, and then we're done. I have a lovely relationship with God, although when I've lost someone or I've seen a sick child, I've had conversations with Him in which I've had to ask, 'How can that be right?'

I think there's so many points of view that you want to make sure your stories are being told from men and women... you get all of the different backgrounds. You don't want every story being told from the same point of view. So just for better storytelling, I'm like, 'Yes, please, bring some more ladies on.'

You push so far past the normal boundaries of what’s O.K. in society. I’m always fully aware of, ‘You can’t do this’… When someone really believes in what they’re saying, but it’s crazy, it’s like my favorite thing on earth… [But] Crazy’s just crazy and there’s nowhere to go. You can have a point of view, it can be very strange, but we have to know your reasoning.

I've never felt like I needed to change. I've always thought, 'If you want somebody different, pick somebody else.' But sure, criticism can sometimes still get to me. Some things are so malicious, they knock the wind out of you. It's like I'm managing to achieve all this success in spite of my affliction... Would you ever put [America's plus-size sweetheart] in the headline for a male star?

Pretty much everyone I know, no matter what size, is trying some system. Even when someone gets to looking like she should be so proud of herself, instead she's like, 'I could be another three pounds less; I could be a little taller and have bigger lips.' Where does it end? You just have to say, 'It's pretty damn good. I am right here at the moment and I'm OK with it. I've got other things to think about.'

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