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Whatever we do would likely happen before or during the events of Mass Effect 3, not after
Um... You know, at this point, I think we're co-creators with the fans. We use a lot of feedback.
We have a rule in our franchise that there is no canon. You as a player decide what your story is.
Every decision you've made will impact how things go. The player's also the architect of what happens.
Fans want to make sure that they see things resolved, they want to get some closure, a great ending. I think they're going to get that.
Mass Effect 3 is all about answering all the biggest questions in the lore, learning about the mysteries and the Protheans and the Reapers, being able to decide for yourself how all of these things come to an end.
For people who are invested in these characters and the back-story of the universe and everything, all of these things come to a resolution in Mass Effect 3. And they are resolved in a way that's very different based on what you would do in those situations.
The whole idea of Mass Effect3 is resolving all of the biggest questions, about the Protheons and the Reapers, and being in the driver's seat to end the galaxy and all of these big plot lines, to decide what civilizations are going to live or die: All of these things are answered in Mass Effect 3.
It's more like there are some really obvious things that are different and then lots and lots of smaller things, lots of things about who lives and who dies, civilizations that rose and fell, all the way down to individual characters. That becomes the state of where you left your galaxy. The endings have a lot more sophistication and variety in them.