Harry [ Hannigan] and Chris [Ellis] are sitting there while we're doing [ Fresh Hell], and Chris is directing, obviously, but if we start fooling around a little bit, Harry comes in, and he's got some addition that makes it even funnier. But we start with a complete script.

I know a guy who writes on the show, it was his episode, and he called and said, "Would you do it?" And I said, "Yeah." There's not really much else to tell, except that I was thrilled to be on The Simpsons, because it's one of the greatest series in the history of television.

The Dain Curse [Tom Fink] was a great job. I was in New York, and I was young - I think I'm 28 years old in that - and I got to work with James Coburn and Jean Simmons and Jason Miller. Plus, it was a Dashiell Hammett story, and I had a great character. It was fantastic to shoot.

Dr. Okun. Who's named after a special-effects guy named Jeff Okun, who had done Stargate for Roland Emmerich and Dean Devlin, who did Independence Day. But "Brakish" just came up one day when Jeff Goldblum and I were improvising, and he told me his character's name and I told him mine.

The one on Fresh Hell is a little easier, because we make it up. It's a strange kind of hybrid of the real me and... Well, obviously it's me standing there, and it's my voice and my face, but it's also kind of filtered through Harry Hannigan's take on the character, the one he's writing.

Both of the Quaid brothers, Randy and Dennis, were in my class, and Tommy Schlamme, who produced and directed The West Wing with Aaron Sorkin, among many others. Marianne Williamson, who did A Course In Miracles, she was in my high-school drama class, too. So it was kind of an amazing class.

Of those, the only one that really stands out for me is Tales From The Darkside, for a couple of reasons, one in particular being who I got to work with on it, which was Eddie Bracken. I mean, what a man. Someone who's done Preston Sturges movies, and I actually got to work with him? And he was great.

I wanted to look right. I remember a review - a very positive one - in The New York Times that said I was so good in the role [Earl Mills] that I "even managed to overcome a terrible red wig." I wanted to write her and tell her about the agony I'd gone through with the perm, but I thought better of it.

When I get to work with people I admire, it's such a bonus, so it was an easy sell when I got this phone call asking, 'Will you do this thing with David Strathairn?'" Also, they didn't ask me to audition, which is another bonus. But they said, "All your scenes will be with David," and I said, "I'm there!"

We were kind of never one of CBS favorites [with Threshold], even though we'd gotten really good reviews for the pilot. We were on at, what was it, 10 o'clock on a Friday night? That's kind of where you bury a show if you don't want it to last. But, wow, what a cast, huh? You could never get that cast together again.

Earl Mills is probably the best role I've ever been given in a film. And it was a great experience to work with Halle [Berry] and Klaus Maria Brandauer, an Austrian actor who's a hero of mine. Martha Coolidge directed the movie [Introducing Dorothy Dandridge], giving me another shot, and it was an amazing experience.

We had lunch that day [with Chris Ellis], and I was talking about this idea. I toyed with it a little bit on Twitter in story form at one point. And he thought it was a great idea, and he thought, "Well, let's bring my friend Harry Hannigan in, who's a wonderful writer, and let's see if we can put something together."

I had a fantastic teacher in high school. I had one of those guys you dream of having, who molds your life and inspires you to go in a particular direction, and he was quite brilliant. His name was Cecil Pickett, and a lot of the kids from my high-school drama class are in professional show business and have done quite well.

It was kind of an amazing class. I went to the Strasberg Institute in New York for a little while after I got there, and I've never seen anybody who was in any of my classes there ever again. I mean, that's not to say they didn't become somebody. I'm not sure. I mean, Sam Jackson could've been in my class, for all I remember.

The woman who wrote the movie [Ladies And Gentlemen, The Fabulous Stains], her name is Nancy Dowd. She's a wonderful writer. She wrote Coming Home. And when I read the script, at that time, I thought, "This movie is going to do for girls what Breaking Away did for boys." I thought it was going to be huge. It was a great script.

Joey being one of my finest performances ever. Matt LeBlanc's basically doing the same thing right now, playing himself on Episodes. When I did Joey, I really leaned on them to make me the biggest ass they possibly could, because, frankly, everyone in their heart of hearts thinks of themselves that way. Or at least I do, anyway.

I had no idea I was part of what was going to be a big mega-hit. I thought I was doing a B sci-fi movie [Independence Day]. And, actually, it was Jeff Goldblum who looked at me one day and said, "You know, I think this is going to be really something." And I said, "Well, I hope you're right." And sure enough, it turned out to be.

I got to play a funny part [in the The Master Of Disguise]. There was one thing my character did that involved flatulence and laughing at the same time - that was in the script - and that was basically what sold me on it. I really thought, "This can't help but be funny." And when I saw the film, I was proud that I'd had those moments.

John Logan is maybe the No. 1 screenwriter in the world today, not to mention that he won a Tony for Best Play for Red. So he may just be the best writer period right now. He wrote The Aviator, and I was in New York doing a play, and he asked if they would see me for the film, just meet with me. 'Cause that's what Martin Scorsese does.

Rent Control was an interesting movie. It was directed by... I had done a couple of plays off Broadway, and this Italian director came, his name was Gian Luigi Polidoro, and he determined I was the person to play the lead in his low-budget comedy. He'd won an award at the Venice Film Festival, and... He was, y'know, a skilled director.

I was, like, "Wow, is this ever going to happen again? Am I ever going to work with another bunch of people I get along with this well?" And then, sure enough, Threshold was just a great bunch of people, and I thought, "Hey, I could hang with these people for a long time!" But, unfortunately, it was 13 episodes and we were out of there.

I really enjoyed doing that [Law & Order: Criminal Intent (2004) - "Graham Barnes"]. I got to work with Margaret Colin, who was a blast to work with, and a wonderful actress, and Taylor Roberts. She was fantastic. And getting to work with Vincent D'Onofrio, who's amazing. But I loved the characters of the parents, these sick psychiatrists.

Obviously we're doing a comedy [Fresh Hell], and our intent is to entertain, but we're also really aware and trying to stay aware of the subtext of what it's like to reach a certain age and be dismissed, basically, from the fraternity you've always wanted to be a part of, and the desperation involved in trying to claw your way back into it.

Initially I objected to the Data makeup. I said, "Why do I need this makeup? Why can't I just look like me?" In fact, I said to Gene Roddenberry, "Don't you think that by this time in history, they would've figured out how to make skin look like skin?" And he said, "What makes you think that what you have isn't better than skin?" And I went, "Um, okay."

So we [with Chris Ellis] did [Fresh Hell], and we did the first five episodes as a lark, just to see if anybody would respond or be interested, and we got enough feedback that was positive that we thought, "Let's keep going with this and see if we can flesh it out a bit this season." We've had 10 episodes, and they've been longer and a little more complete.

Basically, my deal is that I choose roles based on three criteria. One is the role, obviously, if it's something that speaks to me. Two is, are they gonna pay me? And three is, who am I gonna work with? And, really, if one of those is there, I'm pretty likely to do it, but it's particularly important to me who I'm going to work with, 'cause that's part of the joy.

I've toyed with this idea [of Fresh Hell] for a long time. I actually wrote a feature years ago with this sort of concept in mind, and it's gone through several incarnations, and... It wasn't 'til I met Chris Ellis, who directed me in a little thing that was actually for a ride in Universal Singapore, for those of you who happen to be going to Universal Singapore.

It really was not that difficult a process, because I was playing [Data from Star Trek] something that doesn't exist. So it was really based on... Imagination was the key element in that, and whatever I could think of, I could do, because there was no precedent for it. It wasn't like someone was going to say, "Well, an android would never do that." They didn't know!

I did a great show Off-Broadway called Leave It To Beaver Is Dead that was at the Public Theater in New York. It was written by Des McAnuff, who's an illustrious director now, and it starred... Well, I was in it, Mandy Patinkin, Dianne Wiest, Saul Rubinek, and Maury Chaykin. It was an amazing show. But it was definitely ahead of its time, and people didn't quite get it.

That was a really interesting series [Threshold ] that I think would've been really great had it continued. I know Brannon Braga, who was running the show at the time, had a lot of really interesting ideas for what was going to happen the second, third, fourth, and fifth seasons, and they had it really planned out what was going to go on. But CBS just decided to pull the plug on it.

So it was a really pleasant surprise when [Independence Day] turned out to be a successful film. I don't know if you've heard that they're going to be re-releasing it next Fourth of July in 3-D. I've actually only seen it once, and it was in Hawaii, in a little theater in Oahu shortly after it was released. But Roland Emmerich is a really smart guy, and he makes really fun movies to watch.

Like, she had a caterer, she had wardrobe people, she had two makeup artists... I mean, we have makeup and we have wardrobe, but Felicia [Day] was, like, on it. She had two cameras operating, sets, extras everywhere. It was unbelievable. I don't know what her budget was or is, but she had sponsors for her show, and we don't have a sponsor yet, so basically, the difference is, our moms make our costumes.

We [with John Logan] started talking about The Searchers, and then he went on to tell me a story about when he first met John Wayne, and he said, "Hey, you be me and I'll be Wayne," and I said, "No, let me be Wayne!" Anyway, it was a very pleasant conversation, it was clear to him that I was a big movie fan, and by the time I got home, there was a phone call, asking if I'd mind doing one scene in the movie [The Aviator].

A couple of years ago, I went to see a production of Wicked in San Francisco with a friend of mine, one that Patty Duke was in, and he said, "Do you want to meet her?" And I said, "Yeah!" And I went backstage, and she walked out of her dressing room, looked at me, and said, "I know you." And I went, "Well, uh, yeah, I was in My Sweet Charlie." And she said, "Yeah! You were the guy in the car on the road!" And I was. It was amazing.

Of course, when you see [ musical numbers] in the movie [Out To Sea ], it's cut into a lot with other scenes, but we shot the number straight through, so here I am doing it, and sitting right in front of me in the audience was Donald O'Connor. And I was, like, "Oh, my God, I can't believe I'm performing a musical number in front of Donald O'Connor," who's one of the greats of the silver screen. But it was a thrilling experience, it really was.

[Billy Bob Conroy role] that was a favor. Actually, the lady who cast Night Court asked me to do it, because it was a Friday, and the person who'd been rehearsing it all week got sick and couldn't come to the taping. And she figured I could put it together pretty quickly - it was not all that big a challenge, frankly - and I said, "Of course." I owed her, after all. Gilda Stratton was her name. She was a really, really nice person. So I did it.

I have to say, though, that somebody pointed out to me on YouTube that Conan O'Brien was being interviewed, and he was talking about how, oddly enough, he went to see that movie [South Park: Bigger, Longer & Uncut ] in Hawaii with his girlfriend or wife or whoever, and he didn't even realize his character was in it. But there he was, and he said, "This voice comes out of me, and I'm thinking, 'That's not me! Who is that? That doesn't even sound like me!'

I think everyone agrees First Contact was our best film, and even at that, they're kind of... I don't know, they're sort of movies. But they're kind of really Star Trek movies, if you take my meaning. It's hard for me to say. I was glad to be doing them. Whether they were good isn't really up to me to determine, and it doesn't matter what I think. I thought we had a really nice script on Nemesis, and the audience didn't seem to care for it, so what can you do?

I actually had some funny dialogue [ in Stardust Memories], a little piece, and we shot all day in this big ballroom. Gordon Willis was the director of photography, and at the end of the day, Gordon turned to Woody Allen and said, "We cannot accomplish all of this in this space. It's impossible." And we'd been rehearsing and trying to shoot this thing all day. So Woody said, "Okay, let's do something else." He looked at me and said, "Come back tomorrow, I'll put you in something else." And he did.

John Logan was kind of wrapping up - "Well, thanks for coming in..." - and I thought, "Oh, God, this is over and I'm out of here, and I really don't want to leave."So I said, "Can I ask you a question?" He said, "Sure." "What movie do you think you've seen more than any other movie?" And he said, "Wow, let me think about that. I guess probably The Searchers." And I said, "Well, oddly, that's the movie I've seen more than any other movie." And I wasn't just BS-ing. It's true. It's my favorite movie.

[Trey Parker and Matt Stone]called me one Saturday morning and said, "Can you do an impression of Conan O'Brien?" And I said, "I don't know." Because that was really... He hadn't been on the air that long, and to be honest, I hadn't watched much of him at that point. So I went to Santa Monica to their studio and said, "Well, what does he sound like?" They said, "Well, just try it one time. Read the copy." And I read the copy one time, and they went, "Okay, that's fine. Thanks a lot, that'll do. That's perfect."

It wasn't exactly a cattle call. I had an agent, and they were seeing people for the parts, so my agent said, "Here's the script, see if there's anything that speaks to you." And I did, and I called my agent and said, "I think this character Data is kind of interesting," and she said, "Well, okay, I'll get you the appointment with Junie Lowry." I had to read with the casting agent first, 'cause nobody really knew me then. Then after that, I had, I think, six different auditions for the role. And finally it was me [on Star Trek].

I can tell you one other story about Rent Control. The lead actress in the film, her name was Elizabeth Stack, and it turned out she was Robert Stack's daughter. The only problem with that - and she was lovely - was that she was basically hired because [Gian Luigi Polidoro] thought she was [film producer] Ray Stark's daughter. And he figured that if he ran out of money, her father would kick in some more. I can still remember the day he freaked out when he realized she was actually Robert Stack's daughter. He was just screaming "Untouchables!" over and over.

Gian Luigi Polidoro and his girlfriend had written this script, it was an American comedy, and they decided I was the guy to play the part. I was young, they offered me the lead in the film, and I said, "Sure, I'll do it." And I'm telling you, there is a movie waiting to be made about the making of a movie like that, particularly at that time in New York. I mean, we shot all over the streets of New York without permits. We would literally grab a shot and run. But Rent Control... I think the total cost was $100,000, and to this director's credit, I think it looks like $200,000.

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